Dibenzo[a,f]quinolizines: syntheses and cytostatic activity in estrogen-sensitive tumor cells [PDF]
, 1994 A number of methoxy-substituted 7,11b,12,13-tetrahydro-6H-dibenzo-[a,f]quinolizines with short alkyl groups in position 6 or 12 were synthesized by the Bischler-Napieralski reaction using the appropriate starting material followed by a second ring ...
Wiegrebe, Wolfgang +4 more
core +1 more source
Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors
Journal of Immunology Research, 2016 The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.
Hongyan Qian +3 more
doaj +1 more source
Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
Journal of Diabetes Research, 2015 Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action.
Anisha A. Gupte +2 more
doaj +1 more source
Field and laboratory approaches to assess "estrogen disruption" in the brown trout "Salmo trutta" [PDF]
, 2008 In recent years, the annual catches of brown trout and other native fish species have been declining in Switzerland about 60%. One hypothesis was that the reduced catch is linked to estrogen-active chemicals entering the aquatic environment via waste ...
Körner, Oliver
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Estrogen receptor co-regulators as prognostic and predictive markers of endocrine therapy in early breast cancer: the role of SMRT and p160 family [PDF]
, 2010 Background: The estrogen receptor (ER) signaling pathway is the dominant driver of cell proliferation and survival in the majority of human breast cancers.
Migliaccio, Ilenia
core +1 more source
Pakistan Armed Forces Medical Journal, 2022 Objective: To determine the frequency of discordance of receptor status in our breast cancer patients, find out its causes, and suggest remedial measures. Study Design: Retrospective longitudinal study.
Said Zaman Khan +5 more
doaj +1 more source
Research progress of estrogen receptor on prostate cancer [PDF]
Yixue xinzhi zazhi, 2020 Prostate cancer is the most common malignant tumor and the second most common cause of cancer death in men. Estrogen receptors (ERs) are member of steroid hormone receptor superfamily.
Gang-Lin SU +3 more
doaj +1 more source
Dynamic changes in gene expression in vivo predict prognosis of tamoxifen-treated patients with breast cancer [PDF]
, 2010 Tamoxifen is the most widely prescribed anti-estrogen treatment for patients with estrogen receptor (ER)-positive breast cancer. However, there is still a need for biomarkers that reliably predict endocrine sensitivity in breast cancers and these may ...
Liang, Liang +28 more
core +2 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Motif analysis of amphioxus, lamprey and invertebrate estrogen receptors and amphioxus and human estrogen-related receptors: Towards a better understanding of estrogen receptor evolution [PDF]
, 2008 *Background.* The origins of steroid-dependent regulation of the vertebrate estrogen receptor (ER) are poorly understood. Genes with statistically significant sequence similarity to vertebrate ERs have been found in lamprey, a basal vertebrate, and ...
Michael E. Baker +1 more
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