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Molecular Mechanisms of Endocrine Resistance in Estrogen-Receptor-Positive Breast Cancer
The estrogen receptor is a vital receptor for therapeutic targets in estrogen receptor-positive breast cancer. The main strategy for the treatment of estrogen receptor-positive breast cancers is blocking the estrogen action on estrogen receptors by ...
Esmael Besufikad Belachew +2 more
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Abstract Context—A new class of estrogen receptors was discovered in 1996 and named estrogen receptor β (ER-B); the traditional estrogen receptor, which until a little more than 10 years ago was thought of as the only estrogen receptor in existence, is now called estrogen receptor α. Estrogen receptor β has at least 5 isoforms, which may
Mamoun, Younes, Naoko, Honma
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Estrogen and progesterone receptor expression in breast carcinoma
Background: Breast carcinoma is the most common malignancy diagnosed among women worldwide and second leading cause of cancer mortality. One of the hallmarks of the disease is expression of estrogen receptor and progesterone receptor that ultimately ...
TB Pathak +7 more
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Patients with estrogen receptor-negative breast cancer generally have a worse prognosis than estrogen receptor-positive patients. Nevertheless, a significant proportion of the estrogen receptor-negative cases have favorable outcomes. Identifying patients
Jie Hou +3 more
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Abebe Muche Belete,1 Yared Asmare Aynalem,2 Belete Negese Gemeda,2 Tefera Mulugeta Demelew,3 Wondimeneh Shibabaw Shiferaw2 1Department of Biomedical Science, Debre Berhan University, Debre Berhan, Ethiopia; 2Department of Nursing, Debre Berhan University,
Belete AM +4 more
doaj
The importance of simultaneous determination of breast cancer biomarkers [PDF]
It is shown that steroid hormone receptors by themselves are not sufficiently strong prognostic factors in management of breast cancer. For that reason, simultaneous consideration of different biomarkers seems to be more appropriate for clinical use, i.e.
Markićević Milan +3 more
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UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan +1 more
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Function of G-Protein-Coupled Estrogen Receptor-1 in Reproductive System Tumors
The G-protein-coupled estrogen receptor-1 (GPER-1), also known as GPR30, is a novel estrogen receptor mediating estrogen receptor signaling in multiple cell types.
Hongyan Qian +3 more
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Research progress of estrogen receptor on prostate cancer [PDF]
Prostate cancer is the most common malignant tumor and the second most common cause of cancer death in men. Estrogen receptors (ERs) are member of steroid hormone receptor superfamily.
Gang-Lin SU +3 more
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Estrogen: An Emerging Regulator of Insulin Action and Mitochondrial Function
Clinical trials and animal studies have revealed that loss of circulating estrogen induces rapid changes in whole body metabolism, fat distribution, and insulin action.
Anisha A. Gupte +2 more
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