Results 71 to 80 of about 712,236 (344)
Estrogen, estrogen-like molecules and autoimmune diseases
Autoimmunity Reviews, 2020 In western countries, the slope of autoimmune disease (AD) incidence is increasing and affects 5-8% of the population. Mainly prevalent in women, these pathologies are due to thymic tolerance processes breakdown. The female sex hormone, estrogen, is involved in this AD female susceptibility.
Merrheim, Judith +6 more
openaire +3 more sources
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Diagnosis and Management of Vaginal Dryness in Menopause [PDF]
, 2016 Objective: To review the diagnosis and management of vaginal dryness in menopausal womenMethods: Literature reviewResults: Lack of estrogen negatively impacts the vagina and the urinary tract.
Baziad, A. (Ali)
core
Estradiol regulates miR-135b and mismatch repair gene expressions via estrogen receptor-β in colorectal cells. [PDF]
, 2012 Estrogen has anti-colorectal cancer effects which are thought to be mediated by mismatch repair gene (MMR) activity. Estrogen receptor (ER) expression is associated with microRNA (miRNA) expression in ER-positive tumors.
Fu, Lei +6 more
core +1 more source
Pharmacology Research & Perspectives, 2021 Endometriosis is a chronic disease, characterized by the growth of endometrial‐like cells outside the uterine cavity. Due to its complex pathophysiology, a totally resolving cure is yet to be found.
Sara Santorelli +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo +11 more
wiley +1 more source
, 2007 Cutaneous ageing manifests itself as a progressive reduction in maximum function and reserve capacity of skin tissue. It is not a unique and uniform biological event. Skin comprises three layers: epidermis, dermis and subcutaneous tissue.
Brincat, Mark P. +2 more
core +1 more source
Spontaneous inflammatory pelvic disease in adult non-castrated female rats treated with estrogen
Brazilian Journal of Infectious DiseasesThe adaptive immune response of the genital tract is under the control of sexual steroids; however, the influence of sex hormones on innate immune mechanisms of the genital mucosa are only beginning to be understood.
Aristóteles M G Ramos +3 more
doaj +1 more source
Frontiers in Endocrinology, 2020 There are gender differences between men and women in many physiological functions and diseases, which indicates that female sex hormones may be important.
Chelsea DeLeon +2 more
doaj +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021 Background Stress has emerged as an important risk factor for heart disease in women. Stress levels have been shown to correlate with delayed recovery and increased mortality after a myocardial infarction.
Hemangini A. Dhaibar +9 more
doaj +1 more source