Results 91 to 100 of about 90,675 (307)

Estradiol accelerates liver regeneration through estrogen receptor α

Clinical and Experimental Gastroenterology, 2019
Yoji Tsugawa,1 Michiya Natori,2 Hiroshi Handa,3 Takeshi Imai11Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; 2Department of Obstetrics and Gynecology, Tokyo Medical University, Shinjuku ...
Tsugawa Y, Natori M, Handa H, Imai T
doaj  

The effects of female sexual steroids on gastric function and barrier resistance of gastrointestinal tract following traumatic brain injury

Journal of Pharmacy and Bioallied Sciences, 2015
Aim: The aim was to assess the alteration of gastric function and barrier function of gastrointestinal (GI) tract following diffuse brain injury in varying ovarian hormone status. Materials and Methods: Diffuse traumatic brain injury (TBI) was induced by
Zakieh Keshavarzi, Mohammad Khaksari
doaj   +1 more source

3D model of amphioxus steroid receptor complexed with estradiol

, 2009
The origins of signaling by vertebrate steroids are not fully understood. An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.
Michael E. Baker, David J. Chang
core  

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Trichoplax, the simplest known animal, contains an estrogen-related receptor: Implications for the evolution of vertebrate and invertebrate estrogen receptors

, 2008
Although, as their names imply, vertebrate and invertebrate estrogen receptors [ERs] and estrogen-related receptors [ERRs] are related transcription factors, their evolutionary relationships to each other are not fully understood.
Michael E. Baker
core  

Fosl2 Regulates FSH‐Dependent Follicle Maturation Through Feedback Amplification of FSH/FSHR Signaling

Advanced Science, EarlyView.
This study identifies a FOSL2‐driven positive feedback loop that amplifies FSH/FSHR signaling. During FSH‐dependent follicle maturation, FSH induces Fosl2 expression via the cAMP‐PKA‐CREB cascade. FOSL2 in turn binds the promoters of Fshr and estrogen‐biosynthesis genes to enhance their transcription, thereby increasing Fshr mRNA level and amplifying ...
Hongru Shi, Chaoli Chen, Zaohong Ran, Jianning Liao, Zian Wu, Xiaodong Wang, Yongheng Zhao, Wenkai Ke, Bowen Tan, Yun Liu, Youqiang Su, Wei Ren, Xiang Li, Changjiu He   +13 more
wiley   +1 more source

Testosterone and the Male Skeleton: A Dual Mode of Action

Journal of Osteoporosis, 2011
Testosterone is an important hormone for both bone gain and maintenance in men. Hypogonadal men have accelerated bone turnover and increased fracture risk.
Mieke Sinnesael, Steven Boonen, Frank Claessens, Evelien Gielen, Dirk Vanderschueren   +4 more
doaj   +1 more source

Estrogen receptor alpha localization in the testes of men with normal spermatogenesis Estrogen receptor alpha localization in the testes of men with normal spermatogenesis

Folia Histochemica et Cytobiologica, 2012
It is known that estrogens act on the male reproductive tract by binding to estrogen receptors (ER) a and<br />b. However, studies on ER localization in the human testis are discordant.
Eliza Filipiak, Dagmara Suliborska, Maria Laszczynska, Renata Walczak-Jedrzejowska, Elzbieta Oszukowska, Katarzyna Marchlewska, Krzysztof Kula, Jolanta Slowikowska-Hilczer   +7 more
doaj   +1 more source

Activation of an Estrogen/ Estrogen Receptor Signaling by BIG3 Through Its Inhibitory Effect on Nuclear Transport of PHB2/REA in Breast Cancer

, 2009
Breast cancer is known to be a hormone-dependent disease, and estrogens through an interaction with estrogen receptor (ER) enhance the proliferative and metastatic activity of breast tumor cells.
Yusuke Nakamura, Tomomi Ueki, Miki Akiyama, Meng-Lay Lin, Arata Shimo, Jae-Hyun Park, Yataro Daigo, Toyomasa Katagiri, Tatsuhiko Tsunoda, Jung-Won Kim, Toshihiko Nishidate   +10 more
core  

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source