The role of estrogen receptor beta in breast cancer [PDF]
Biomarker Research, 2020 Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve ...
Yujing Zhou, Xingdang Liu
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Estrogen receptor beta expression in prostate adenocarcinoma [PDF]
Diagnostic Pathology, 2011 Background Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many ...
Asgari Mojgan, Morakabati Arman
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Estrogen rescues heart failure through estrogen receptor Beta activation [PDF]
Biology of Sex Differences, 2018 Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga +9 more
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Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor [PDF]
Frontiers in Oncology, 2020 Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the ...
Rahul Mal +25 more
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Estrogen receptors alpha and beta in bone [PDF]
Bone, 2016 Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Susan Krum, Aysha Khalid
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OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist [PDF]
Scientific ReportsEstrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young +13 more
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Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer [PDF]
Chinese Medical Journal. Background:. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options.
Feng Xu +9 more
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Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases [PDF]
International Journal of Molecular Sciences, 2021 Milena Krajnovic +2 more
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Therapeutic Targeting of Ovarian Cancer Stem Cells Using Estrogen Receptor Beta Agonist [PDF]
International Journal of Molecular Sciences, 2022 Gangadhara Reddy Sareddy +2 more
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Anti-Apoptotic and Antioxidant Activities of the Mitochondrial Estrogen Receptor Beta in N2A Neuroblastoma Cells [PDF]
International Journal of Molecular Sciences, 2021 Demetres Leonidas +2 more
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