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The role of estrogen receptor beta in breast cancer [PDF]

Biomarker Research, 2020
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most common cancer among women worldwide. Challenges facing the diagnosis and treatment of breast cancer necessitate the search for new mechanisms and drugs to improve ...
Yujing Zhou, Xingdang Liu
doaj   +2 more sources

Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells

Tumor Biology, 2017
Human testis, gonocytes, and adult germ cells mainly express estrogen receptor beta, and estrogen receptor beta loss is associated with advanced tumor stage; however, the molecular mechanisms of estrogen receptor beta–protective effects are still to be ...
Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, Saveria Aquila   +10 more
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Estrogen Receptor Beta (ERβ): A Ligand Activated Tumor Suppressor [PDF]

Frontiers in Oncology, 2020
Estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) belong to a superfamily of nuclear receptors called steroid hormone receptors, which, upon binding ligand, dimerize and translocate to the nucleus where they activate or repress the ...
Rahul Mal, Alexa Magner, Joel David, Jharna Datta, Meghna Vallabhaneni, Mahmoud Kassem, Mahmoud Kassem, Jasmine Manouchehri, Natalie Willingham, Daniel Stover, Daniel Stover, Jeffery Vandeusen, Jeffery Vandeusen, Sagar Sardesai, Sagar Sardesai, Nicole Williams, Nicole Williams, Robert Wesolowski, Robert Wesolowski, Maryam Lustberg, Maryam Lustberg, Ramesh K. Ganju, Bhuvaneswari Ramaswamy, Bhuvaneswari Ramaswamy, Mathew A. Cherian, Mathew A. Cherian   +25 more
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OSU-ERβ-12: a promising pre-clinical candidate selective estrogen receptor beta agonist [PDF]

Scientific Reports
Estrogen receptor beta (ERβ) is a favorable therapeutic target for mediating inflammation, attenuating fibrosis, and treating cancer. However, selectively targeting ERβ over estrogen receptor alpha (ERα) has been a longstanding challenge.
Gregory M. Young, Timothy H. Helms, Samuel K. Kulp, Adeoluwa A. Adeluola, Hanna S. Radomska, Tyler A. Wilson, Reena Shakya, Alyssa Kabat, Gillian Mulcahy, Abigail K. Mayo, Raphael A. Malbrue, William C. Kisseberth, Chad E. Bennett, Christopher C. Coss   +13 more
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Estrogen receptor beta suppresses the androgen receptor oncogenic effects in triple-negative breast cancer [PDF]

Chinese Medical Journal
. Background:. Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer associated with poor prognosis and limited treatment options.
Feng Xu, Kun Xu, Lingling Fan, Xintong Li, Yiqiu Liu, Fang Yang, Chengjun Zhu, Xiaoxiang Guan, Ting Gao, Xiuyuan Hao   +9 more
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Estrogen Receptor Beta: The Promising Biomarker and Potential Target in Metastases [PDF]

International Journal of Molecular Sciences, 2021
Ana Bozovic, Vesna Mandusic, Lidija Todorovic   +2 more
exaly   +2 more sources

Anti-Apoptotic and Antioxidant Activities of the Mitochondrial Estrogen Receptor Beta in N2A Neuroblastoma Cells [PDF]

International Journal of Molecular Sciences, 2021
Ioannis Tsialtas, Maria E Karipidou, Demetrios D Leonidas   +2 more
exaly   +2 more sources

Coumestrol Alleviates Oxidative Stress, Apoptosis and Cognitive Impairments Through Hippocampal Estrogen Receptor-Beta in Male Mouse Model of Chronic Restraint Stress [PDF]

Pharmaceutical Sciences, 2022
Background: Coumestrol is well-known as a natural estrogen receptor-beta modulator. Since the role of estrogen receptors in controlling stressful situations has already been reported and their cognitive functions in hippocampus seem to be independent of ...
Kiarash Fekri, Javad Mahmoudi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Alireza Mohajjel Nayebi   +4 more
doaj   +1 more source

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source