Results 41 to 50 of about 73,581 (158)

Expression and regulation of estrogen receptor 2 and its coregulators in mouse granulosa cells

The Journal of Reproduction and Development, 2022
The cooperative effects of estrogen and oocyte-derived paracrine factors (ODPFs) play critical roles in the normal development of ovarian follicles; however, the mechanism underlying this cooperation has not been well studied.
Chihiro EMORI, Takuya KANKE, Haruka ITO, Yuki AKIMOTO, Wataru FUJII, Kunihiko NAITO, Koji SUGIURA   +6 more
doaj   +1 more source

Interaction of Phytoestrogens with Estrogen Receptors .ALPHA. and .BETA..

Biological and Pharmaceutical Bulletin, 2001
The human estrogen receptor (hER) exists as two subtypes, hER alpha and hER beta, that differ in the C-terminal ligand-binding domain and in the N-terminal transactivation domain. In this study, we investigated the estrogenic activities of soy isoflavones after digestion with enteric bacteria in competition binding assays with hER alpha or hER beta ...
MORITO, Keiko, HIROSE, Toshiharu, KINJO, Junei, HIRAKAWA, Tomoki, OKAWA, Masafumi, NOHARA, Toshihiro, OGAWA, Sumito, INOUE, Satoshi, MURAMATSU, Masami, MASAMUNE, Yukito   +9 more
openaire   +2 more sources

Expression profile and prognostic role of sex hormone receptors in gastric cancer

BMC Cancer, 2012
Background Increasing interest has been devoted to the expression and possible role of sex hormone receptors in gastric cancer, but most of these findings are controversial. In the present study, the expression profile of sex hormone receptors in gastric
Gan Lu, He Jian, Zhang Xia, Zhang Yong-Jie, Yu Guan-Zhen, Chen Ying, Pan Jun, Wang Jie-Jun, Wang Xi   +8 more
doaj   +1 more source

Mitochondrial localization of estrogen receptor β [PDF]

Proceedings of the National Academy of Sciences, 2004
Estrogen receptors (ERs) are believed to be ligand-activated transcription factors belonging to the nuclear receptor superfamily, which on ligand binding translocate into the nucleus and activate gene transcription. To date, two ERs have been identified: ERα and ERβ.
Shao-Hua, Yang, Ran, Liu, Evelyn J, Perez, Yi, Wen, Stanley M, Stevens, Thomas, Valencia, Anne-Marie, Brun-Zinkernagel, Laszlo, Prokai, Yvonne, Will, James, Dykens, Peter, Koulen, James W, Simpkins   +11 more
openaire   +2 more sources

Estrogen Receptor Beta Displays Cell Cycle-Dependent Expression and Regulates the G1 Phase through a Non-Genomic Mechanism in Prostate Carcinoma Cells

Cellular Oncology, 2008
Background: It is well known that estrogens regulate cell cycle progression, but the specific contributions and mechanisms of action of the estrogen receptor beta (ERβ) remain elusive.
Antoni Hurtado, Tomàs Pinós, Anna Barbosa-Desongles, Sandra López-Avilés, Jordi Barquinero, Jordi Petriz, Albert Santamaria-Martínez, Joan Morote, Inés de Torres, Joaquim Bellmunt, Jaume Reventós, Francina Munell   +11 more
doaj   +1 more source

Estrogen Receptor Beta and G‐Protein Coupled Estrogen Receptor are Located and Activated on Microglia by Estrogen

The FASEB Journal, 2018
Upon menopause, women have an increased risk of cardiovascular disease, in part due to the decrease in estrogen production that occurs. While estrogen's cardioprotective effects have been known for many years, the exact mechanism of this protection is still under investigation.
Katherine Dvorak, Michael Boyer, Maria J. Barnes, Sarah C. Clayton   +3 more
openaire   +1 more source

Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site

Nature Communications, 2019
Taxanes are natural products which bind beta-tubulin, stabilize microtubules and have a broad spectrum of anticancer activity. Here authors employ a computational binding site similarity screen and cell-based assays to reveal a SERM cross-reactivity ...
Yu-Chen Lo, Olga Cormier, Tianyun Liu, Kendall W. Nettles, John A. Katzenellenbogen, Tim Stearns, Russ B. Altman   +6 more
doaj   +1 more source

Differential contribution of estrogen receptors to the intestinal therapeutic effects of 17β-estradiol in a murine model of Parkinson’s disease

Brain Research Bulletin, 2022
Beneficial effects of estrogens have been reported in Parkinson's disease (PD) for many years. We previously reported their neuroprotective and anti-inflammatory potentials in the enteric nervous system of the intestine, a region possibly affected during
Andrée-Anne Poirier, Mélissa Côté, Mélanie Bourque, Hend Jarras, Jérôme Lamontagne-Proulx, Marc Morissette, Thérèse Di Paolo, Denis Soulet   +7 more
doaj   +1 more source

Estrogen receptor beta treats Alzheimer's disease.

Neural regeneration research, 2013
In vitro studies have shown that estrogen receptor β can attenuate the cytotoxic effect of amyloid β protein on PC12 cells through the Akt pathway without estrogen stimulation. In this study, we aimed to observe the effect of estrogen receptor β in Alzheimer's disease rat models established by intraventricular injection of amyloid β protein.
Tian, Zhu, Fan, Jia, Zhao, Yang, Bi, Sheng, Si, Lihui, Liu, Qun   +5 more
openaire   +2 more sources

Estrogen Receptors α and β [PDF]

Circulation, 2000
Background —Estrogens have vascular effects through the activation of estrogen receptors (ERs). In addition to ERα, the first ER to be cloned, a second subtype called ERβ has recently been discovered. Methods and Results —Using a reverse-transcriptase polymerase chain reaction assay
Y K, Hodges, L, Tung, X D, Yan, J D, Graham, K B, Horwitz, L D, Horwitz   +5 more
openaire   +2 more sources