Results 41 to 50 of about 150,800 (299)

Role of estrogen receptors in health and disease

Frontiers in Endocrinology, 2022
Estrogen receptors (ERs) regulate multiple complex physiological processes in humans. Abnormal ER signaling may result in various disorders, including reproductive system-related disorders (endometriosis, and breast, ovarian, and prostate cancer), bone ...
Peng Chen, Bo Li, Ling Ou-Yang
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The Impact of Estrogen and Estrogen-Like Molecules in Neurogenesis and Neurodegeneration: Beneficial or Harmful?

Frontiers in Cellular Neuroscience, 2021
Estrogens and estrogen-like molecules can modify the biology of several cell types. Estrogen receptors alpha (ERα) and beta (ERβ) belong to the so-called classical family of estrogen receptors, while the G protein-coupled estrogen receptor 1 (GPER-1 ...
Felipe A. Bustamante-Barrientos, Felipe A. Bustamante-Barrientos, Maxs Méndez-Ruette, Alexander Ortloff, Patricia Luz-Crawford, Patricia Luz-Crawford, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Francisco J. Rivera, Carlos D. Figueroa, Carlos D. Figueroa, Luis Molina, Luis Federico Bátiz, Luis Federico Bátiz   +14 more
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Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). [PDF]

, 2009
Matrix metalloproteinases (MMPs) have a crucial function in migration of inflammatory cells into the central nervous system (CNS). Levels of MMP-9 are elevated in multiple sclerosis (MS) and predict the occurrence of new active lesions on magnetic ...
Du, Sienmi, Gold, Stefan M, Morales, Laurie B, Sasidhar, Manda V, Sicotte, Nancy L, Tiwari-Woodruff, Seema K, Voskuhl, Rhonda R   +6 more
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Estrogen receptor beta--a new dimension in estrogen mechanism of action [PDF]

Journal of Endocrinology, 1999
The cloning of estrogen receptor (ER ) has provided the first example of a steroid hormone receptor existing as two isoforms, each of which is encoded by a separate gene (Kuiper et al. 1996). The finding of ER was met with great surprise, as the existence of more than one estrogen receptor had been actively denied for several decades. Attempts to clone
openaire   +2 more sources

Estrogen receptor ß is involved in the anorectic action of estrogen [PDF]

International Journal of Obesity, 2002
Estrogen has been implicated in feeding behavior and adiposity. This study was undertaken to elucidate the mechanism underlying the anti-obesity and anorectic action of estrogen and the role of estrogen receptor (ER) in the central nervous system.Ovariectomy in 8-week-old female Wistar rats induced hyperphagia along with an increase in body weight and ...
Y-Q, Liang, M, Akishita, S, Kim, J, Ako, M, Hashimoto, K, Iijima, Y, Ohike, T, Watanabe, N, Sudoh, K, Toba, M, Yoshizumi, Y, Ouchi   +11 more
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Hormonal regulation of female reproduction [PDF]

, 2012
Reproduction is an event that requires the coordination of peripheral organs with the nervous system to ensure that the internal and external environments are optimal for successful procreation of the species.
Bentley, G. E., Cabrera Kreiker, Ricardo Jorge, Christensen, A., Micevych, P., Ortega, Hugo Hector, Perfito, N., Wu, T. J.   +6 more
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Dopamine agonist and tamoxifen combination therapy for a prolactin-secreting pituitary tumor resistant to dopamine agonist monotherapy: Case report and review

Interdisciplinary Neurosurgery, 2020
Background: The majority of prolactin-secreting pituitary macroadenomas are effectively managed with dopamine-agonist therapy alone. Although surgical resection and radiotherapy are second- and third-line treatment options, there remains a paucity of ...
Zachary K. Christian, Kimmo J. Hatanpaa, Richard J. Auchus, Stephen R. Hammes, Ankur R. Patel, Bruce E. Mickey   +5 more
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Estrogens promote misfolded proinsulin degradation to protect insulin production and delay diabetes [PDF]

, 2018
Summary: Conjugated estrogens (CE) delay the onset of type 2 diabetes (T2D) in postmenopausal women, but the mechanism is unclear. In T2D, the endoplasmic reticulum (ER) fails to promote proinsulin folding and, in failing to do so, promotes ER stress and
Allard, Camille, Alvarez-Mercado, Ana I, Arvan, Peter, Coons, Laurel A, Floyd, Z. Elizabeth, Fuselier, Taylor, Hewitt, Sylvia C, Kim, Jun Ho, Korach, Kenneth S, Levin, Ellis R, Mauvais-Jarvis, Franck, Urano, Fumihiko, Xu, Beibei   +12 more
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Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β [PDF]

Endocrinology, 1998
The rat, mouse and human estrogen receptor (ER) exists as two subtypes, ER alpha and ER beta, which differ in the C-terminal ligand-binding domain and in the N-terminal transactivation domain. In this study, we investigated the estrogenic activity of environmental chemicals and phytoestrogens in competition binding assays with ER alpha or ER beta ...
G G, Kuiper, J G, Lemmen, B, Carlsson, J C, Corton, S H, Safe, P T, van der Saag, B, van der Burg, J A, Gustafsson   +7 more
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Detection of estrogen receptors ER-alpha and ER-beta in human ejaculated immature spermatozoa with excess residual cytoplasm

Reproductive Biology and Endocrinology, 2006
Background A key role of estrogens in human sperm biology has been recently suggested by aromatase and estrogen receptor detection in human testicular germ cells and ejaculated spermatozoa.
Aquila Saveria, Siciliano Laura, Rago Vittoria, Carpino Amalia   +3 more
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