Results 1 to 10 of about 90,675 (307)

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Advanced Biomedical Research, 2017
Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani   +2 more
doaj   +3 more sources

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines [PDF]

BMC Cancer, 2009
Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
doaj   +3 more sources

Estrogen receptor alpha dynamics and plasticity during endocrine resistance [PDF]

Biology Direct
Background Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among this, ERα positive breast cancer,
Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi, T. R. Santhoshkumar   +14 more
doaj   +2 more sources

TRIM33 Is a Co-Regulator of Estrogen Receptor Alpha. [PDF]

Cancers (Basel)
Estrogen receptor alpha (ER)-positive breast cancer is responsible for over 60% of breast cancer cases in the U.S. Among patients diagnosed with early-stage ER+ disease, 1/3 will experience recurrence despite treatment with adjuvant endocrine therapy. ER is a nuclear hormone receptor responsible for estrogen-driven tumor growth.
Romo BA, Karakyriakou B, Cressey L, Brauer BL, Yang H, Warren A, Johnson AL, Kettenbach AN, Miller TW.   +8 more
europepmc   +3 more sources

Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells [PDF]

Diagnostics
This work examined the potential benefit of curcumin in breast cancer patients as a supplementary drug in ER-positive cancers. The results indicated that in the MCF-7 human breast cancer cell line, E2 and curcumin decreased cell proliferation and the ...
Lorena Palacios-Navarro, Leodan A. Crispin, Juan P. Muñoz, Gloria M. Calaf   +3 more
doaj   +2 more sources

Cadmium activation of wild-type and constitutively active estrogen receptor alpha [PDF]

Frontiers in Endocrinology
The estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of ESR1, are associated with acquired ...
John B. Psaltis, Qiaochu Wang, Gai Yan, Reem Gahtani, Nanxi Huang, Bassem R. Haddad, Mary Beth Martin, Mary Beth Martin   +7 more
doaj   +2 more sources

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire   +2 more sources

The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer [PDF]

Breast Cancer Research, 2004
Current hormonal therapies have benefited millions of patients with breast cancer. Their success, however, is often temporary and limited to a subset of patients whose tumors express estrogen receptor alpha (ER). The therapies are entirely ineffective in ER-negative disease. Recent studies suggest that there are many biological pathways and alterations
Allred, D Craig, Brown, Powel, Medina, Daniel   +2 more
openaire   +4 more sources

Estrogen Receptor Alpha Gene Polymorphisms and Stroke [PDF]

Cerebrovascular Diseases, 2008
lated to stroke [8] . In addition, using diplotype analysis we found that female patients less frequently had the CCGG diplotype compared to men and that female patients with TTAA diplotype tended to have a higher stroke incidence compared to females with other diplotypes [4] . Since both the studies by Strand et al.
Markoula, S., Lazaros, L., Xita, N., Giannopoulos, S., Georgiou, I., Kyritsis, A. P.   +5 more
openaire   +3 more sources