Results 1 to 10 of about 165,250 (305)

UJI IN SILICO SENYAWA 2,6-DIHIDROKSIANTRAQUINON SEBAGAI LIGAN PADA RESEPTOR ESTROGEN ALFA [PDF]

Jurnal Farmasi Sains dan Komunitas, 2015
Previous studies has shown that estrogen receptor alpha that binds to estrogen may increase cancer cell proliferation, thus estrogen receptor alpha can be targeted to cure breast cancer.
Felicia Fraulein Setiawan, Enade Perdana Istyastono   +1 more
doaj   +4 more sources

BMPR2 expression is suppressed by signaling through the estrogen receptor [PDF]

Biology of Sex Differences, 2012
Background Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways.
Austin Eric D, Hamid Rizwan, Hemnes Anna R, Loyd James E, Blackwell Tom, Yu Chang, Phillips III John A, Gaddipati Radhika, Gladson Santhi, Gu Everett, West James, Lane Kirk B   +11 more
doaj   +4 more sources

Estrogen receptor alpha dynamics and plasticity during endocrine resistance [PDF]

Biology Direct
Background Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among this, ERα positive breast cancer,
Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi, T. R. Santhoshkumar   +14 more
doaj   +2 more sources

Effects of Curcumin and Estrogen Receptor Alpha in Luminal Breast Cancer Cells [PDF]

Diagnostics
This work examined the potential benefit of curcumin in breast cancer patients as a supplementary drug in ER-positive cancers. The results indicated that in the MCF-7 human breast cancer cell line, E2 and curcumin decreased cell proliferation and the ...
Lorena Palacios-Navarro, Leodan A. Crispin, Juan P. Muñoz, Gloria M. Calaf   +3 more
doaj   +2 more sources

Cadmium activation of wild-type and constitutively active estrogen receptor alpha [PDF]

Frontiers in Endocrinology
The estrogen receptor alpha (ERα) plays a central role in the etiology, progression, and treatment of breast cancers. Constitutively activating somatic mutations Y537S and D538G, in the ligand binding domain (LBD) of ESR1, are associated with acquired ...
John B. Psaltis, Qiaochu Wang, Gai Yan, Reem Gahtani, Nanxi Huang, Bassem R. Haddad, Mary Beth Martin, Mary Beth Martin   +7 more
doaj   +2 more sources

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

MATH: A Deep Learning Approach in QSAR for Estrogen Receptor Alpha Inhibitors

Molecules, 2023
Breast cancer ranks as the second leading cause of death among women, but early screening and self-awareness can help prevent it. Hormone therapy drugs that target estrogen levels offer potential treatments.
Rizki Triyani Pusparini, Adila Alfa Krisnadhi, Firdayani   +2 more
doaj   +1 more source

Whole-genome cartography of estrogen receptor alpha binding sites. [PDF]

PLoS Genetics, 2007
Using a chromatin immunoprecipitation-paired end diTag cloning and sequencing strategy, we mapped estrogen receptor alpha (ERalpha) binding sites in MCF-7 breast cancer cells.
Chin-Yo Lin, Vinsensius B Vega, Jane S Thomsen, Tao Zhang, Say Li Kong, Min Xie, Kuo Ping Chiu, Leonard Lipovich, Daniel H Barnett, Fabio Stossi, Ailing Yeo, Joshy George, Vladimir A Kuznetsov, Yew Kok Lee, Tze Howe Charn, Nallasivam Palanisamy, Lance D Miller, Edwin Cheung, Benita S Katzenellenbogen, Yijun Ruan, Guillaume Bourque, Chia-Lin Wei, Edison T Liu   +22 more
doaj   +1 more source

Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer

Acta Biochimica Indonesiana, 2021
Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer.
Dona Marisa, Lisda Hayatie, Siti Juliati, Eko Suhartono, Noer Komari   +4 more
doaj   +1 more source