Results 1 to 10 of about 2,132,538 (302)

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Susan Krum, Aysha Khalid
exaly   +3 more sources

Estrogen and hypoxia regulate estrogen receptor alpha in a synergistic manner

Biochemical and Biophysical Research Communications, 2009
Hypoxia activates and degrades estrogen receptor alpha (ERalpha) in human breast cancer cells, which may play an important role in the development and progression of breast cancer. In this study, the synergistic effects of estrogen (E(2)) and hypoxia on ERalpha-mediated transactivation and ERalpha degradation were investigated.
Youngjoo Lee
exaly   +3 more sources

Altered expression of estrogen receptor alpha and beta in advanced gastric adenocarcinoma: Correlation with prothymosin alpha and clinicopathological parameters

European Journal of Surgical Oncology, 2007
exaly  

Intron 1 and exon 1 alpha estrogen receptor gene polymorphisms in women with endometriosis

Fertility and Sterility, 2008
Naiara C Nogueira de Souza, Eduardo Schor   +1 more
exaly  

Preliminary Molecular Dynamic Simulations of the Estrogen Receptor Alpha Ligand Binding Domain from Antagonist to Apo

International Journal of Environmental Research and Public Health, 2008
Adrian Roitberg
exaly  

Identification of a new isoform of the human estrogen receptor-alpha (hER-alpha) that is encoded by distinct transcripts and that is able to repress hER-alpha activation function 1

EMBO Journal, 2000
Gilles Flouriot, Martin Koß, Raphaël Métivier   +2 more
exaly  

Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis

Cells, 2021
Estrogen receptor alpha (ERα, NR3A1) contributes through its expression in different tissues to a spectrum of physiological processes, including reproductive system development and physiology, bone mass maintenance, as well as cardiovascular and central ...
Lucas Porras, Houssam Ismail, Sylvie Mader   +2 more
doaj   +3 more sources

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Advanced Biomedical Research, 2017
Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani   +2 more
doaj   +3 more sources

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines [PDF]

BMC Cancer, 2009
Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
doaj   +3 more sources

Estrogen receptor alpha dynamics and plasticity during endocrine resistance [PDF]

Biology Direct
Background Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among this, ERα positive breast cancer,
Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi, T. R. Santhoshkumar   +14 more
doaj   +2 more sources