Results 41 to 50 of about 90,675 (307)

Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. [PDF]

PLoS ONE, 2013
An increasing body of evidence now links estrogenic signalling with the metabolic syndrome (MS). Despite the beneficial estrogenic effects in reversing some of the MS symptoms, the underlying mechanisms remain largely undiscovered.
Marko Matic, Galyna Bryzgalova, Hui Gao, Per Antonson, Patricia Humire, Yoko Omoto, Neil Portwood, Camilla Pramfalk, Suad Efendic, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

Estrogen Receptor Alpha Polymorphisms and the Risk of Malignancies

Pathology & Oncology Research, 2010
Estrogens represent risk factors for endocrine-related cancers and play also an important role in the development and progression of other malignancies. In order to analyze the associations between estrogen receptor gene alpha polymorphisms and cancers susceptibility, we genotyped six single nucleotide polymorphisms (SNPs) in 163 Caucasian cancer ...
Andrei, Anghel, Diana, Narita, Edward, Seclaman, Emilian, Popovici, Mariana, Anghel, Liviu, Tamas   +5 more
openaire   +2 more sources

Expression of estrogen and progesterone receptors in astrocytomas: a literature review

Clinics
Gliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares, Francisca das Chagas Sheyla Almeida Gomes-Braga, Danylo Rafhael Costa-Silva, Carla Solange Escórcio-Dourado, Umbelina Soares Borges, Airton Mendes Conde-Junior, Maria da Conceição Barros-Oliveira, Emerson Brandão Sousa, Lorena da Rocha Barros, Luana Mota Martins, Gil Facina, Benedito Borges da-Silva   +11 more
doaj   +1 more source

BMPR2 expression is suppressed by signaling through the estrogen receptor

Biology of Sex Differences, 2012
Background Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways.
Austin Eric D, Hamid Rizwan, Hemnes Anna R, Loyd James E, Blackwell Tom, Yu Chang, Phillips III John A, Gaddipati Radhika, Gladson Santhi, Gu Everett, West James, Lane Kirk B   +11 more
doaj   +1 more source

17β-Hydroxysteroid dehydrogenase type I and aromatase in ovarian cortical inclusion cysts

Endocrine Connections
Previous evidence suggests a link between the ovarian surface epithelium and cortical inclusion cysts and the origin of epithelial ovarian cancer.
Enrique Pedernera, Flavia Morales-Vásquez, Delia Pérez-Montiel, Elizabeth Rendon, Esteban Mena, Laura Diaz-Cueto, Carmen Mendez   +6 more
doaj   +1 more source

Effects of Inhibiting the Proteasomal Degradation of Estrogen Receptor .ALPHA. on Estrogen Receptor .ALPHA. Activation under Hypoxic Conditions

Biological and Pharmaceutical Bulletin, 2009
Hypoxia, which is intimately associated with the biology of breast carcinomas, modulates the level of estrogen receptor (ER) alpha expression and transactivation. We investigated the effect of blocking ER degradation on ERalpha-mediated transactivation under hypoxic conditions using the proteasome inhibitor MG132.
Park, Yeo Myeong, Cho, Jung Yoon, Koo, Young Do, Lee, Young Joo   +3 more
openaire   +3 more sources

GnRH receptor activation competes at a low level with growth signaling in stably transfected human breast cell lines [PDF]

, 2011
Breakthrough Breast CancerBackground: Gonadotrophin releasing hormone (GnRH) analogs lower estrogen levels in pre-menopausal breast cancer patients. GnRH receptor (GnRH-R) activation also directly inhibits the growth of certain cells.
Sims Andrew H, Faratian Dana, Miller, Nicola, Sims, Andrew H., Morgan, Kevin, Miller Nicola, Millar, Robert P., Langdon, Simon P., Ilgin Cagnan, Sims, Andrew, Dana Faratian, Robert P Millar, Meyer, Colette, Simon P Langdon, Colette Meyer, Harrison David J, Cagnan, Ilgin, Nicola Miller, Morgan Kevin, Millar Robert P, David J Harrison, Faratian, Dana, Langdon Simon P, Kevin Morgan, Meyer Colette, Cagnan Ilgin, Andrew H Sims, Harrison, David J.   +27 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Genistein as an Estrogen Receptor-Beta Selective Phytoestrogen: Molecular Docking Insights for Advanced Wound Healing Therapies [PDF]

BIO Web of Conferences
Wound healing is highly hormonal based and is stepwise process involving inflammation, proliferation, and remodeling .Estrogen is a key regulator having two receptor subtypes having various functions.
Varma Greeshma, Manivel Gowdham, Priyadarsini S. Lakshmi   +2 more
doaj   +1 more source

Expression of Estrogen Receptor-alpha in Nasal Polyps and the Effects of Dexamethasone on Estrogen Receptor-alpha Expression in RPMI 2650 Cells [PDF]

Journal of Korean Medical Science, 2020
Studies have reported that epithelial cell proliferation may be involved in the pathogenesis of nasal polyps (NPs). Estrogen receptor (ER)-α, one type of ER, is related to anti-inflammatory action and cell survival in certain tissues. In this study, we examined the presence or absence of ER-α in NPs and healthy inferior turbinate mucosae.
Won Woo Ban, Yoon Jin Lee, Sang Han Lee, Jae Yeop Jung, Byoung Joon Baek   +4 more
openaire   +2 more sources