Nature Communications, 2022 Estrogen secreted by the ovary controls how the brain drives pulsatile reproductive hormone secretion. The authors show that in mice, estrogen receptor alpha within a specific population of hypothalamic kisspeptin neurons is the principal pathway through
H. James McQuillan +8 more
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TRIM3 facilitates estrogen signaling and modulates breast cancer cell progression
Cell Communication and Signaling, 2022 Background Breast cancer is the most common cancer in women worldwide. More than 70% of breast cancers are estrogen receptor (ER) alpha positive. Compared with ER alpha-negative breast cancer, which is more aggressive and has a shorter survival time, ER ...
Ting Zhuang +17 more
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Estrogen signalling and the metabolic syndrome: targeting the hepatic estrogen receptor alpha action. [PDF]
PLoS ONE, 2013 An increasing body of evidence now links estrogenic signalling with the metabolic syndrome (MS). Despite the beneficial estrogenic effects in reversing some of the MS symptoms, the underlying mechanisms remain largely undiscovered.
Marko Matic +11 more
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Expression of estrogen and progesterone receptors in astrocytomas: a literature review
ClinicsGliomas are the most common type of primary central nervous system neoplasm. Astrocytomas are the most prevalent type of glioma and these tumors may be influenced by sex steroid hormones.
Cléciton Braga Tavares +11 more
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BMPR2 expression is suppressed by signaling through the estrogen receptor
Biology of Sex Differences, 2012 Background Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways.
Austin Eric D +11 more
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17β-Hydroxysteroid dehydrogenase type I and aromatase in ovarian cortical inclusion cysts
Endocrine ConnectionsPrevious evidence suggests a link between the ovarian surface epithelium and cortical inclusion cysts and the origin of epithelial ovarian cancer.
Enrique Pedernera +6 more
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Genistein as an Estrogen Receptor-Beta Selective Phytoestrogen: Molecular Docking Insights for Advanced Wound Healing Therapies [PDF]
BIO Web of ConferencesWound healing is highly hormonal based and is stepwise process involving inflammation, proliferation, and remodeling .Estrogen is a key regulator having two receptor subtypes having various functions.
Varma Greeshma +2 more
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Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion. [PDF]
PLoS ONE, 2008 BackgroundEstrogen is an established enhancer of breast cancer development, but less is known on its effect on local progression or metastasis. We studied the effect of estrogen receptor recruitment on actin cytoskeleton remodeling and breast cancer cell
Maria Silvia Giretti +10 more
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Estrogen rescues heart failure through estrogen receptor Beta activation
Biology of Sex Differences, 2018 Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga +9 more
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Nature Communications, 2019 Estrogen promotes negative energy balance and preserves skeletal physiology. Here the authors show that loss of estrogen signalling after ablating estrogen receptor alpha (ERa) in specific hypothalamic neuronal populations leads to a marked sex-dependent
Candice B. Herber +13 more
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