Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. [PDF]
PLoS ONE, 2009 While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones.
Aaron W James +8 more
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Estrogen receptors alpha and beta in bone [PDF]
Bone, 2016 Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
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Expression of Estrogen Receptor Alpha in Malignant Melanoma
Advanced Biomedical Research, 2017 Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi +2 more
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Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines [PDF]
BMC Cancer, 2009 Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
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Estradiol accelerates liver regeneration through estrogen receptor α
Clinical and Experimental Gastroenterology, 2019 Yoji Tsugawa,1 Michiya Natori,2 Hiroshi Handa,3 Takeshi Imai11Department of Aging Intervention, National Center for Geriatrics and Gerontology, Obu, Aichi 474-8511, Japan; 2Department of Obstetrics and Gynecology, Tokyo Medical University, Shinjuku ...
Tsugawa Y, Natori M, Handa H, Imai T
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Estrogen Receptor Alpha Gene Polymorphisms and Stroke [PDF]
Cerebrovascular Diseases, 2008 lated to stroke [8] . In addition, using diplotype analysis we found that female patients less frequently had the CCGG diplotype compared to men and that female patients with TTAA diplotype tended to have a higher stroke incidence compared to females with other diplotypes [4] . Since both the studies by Strand et al.
Markoula, S. +5 more
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The origins of estrogen receptor alpha-positive and estrogen receptor alpha-negative human breast cancer [PDF]
Breast Cancer Research, 2004 Current hormonal therapies have benefited millions of patients with breast cancer. Their success, however, is often temporary and limited to a subset of patients whose tumors express estrogen receptor alpha (ER). The therapies are entirely ineffective in ER-negative disease. Recent studies suggest that there are many biological pathways and alterations
Allred, D Craig +2 more
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ESRRA (estrogen-related receptor alpha) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on ESRRA (estrogen-related receptor alpha), with data on DNA, on the protein encoded, and where the gene is implicated.
Stein, Kunder R, McDonnell, DP
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Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]
Seminars in Reproductive Medicine, 2010 Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E. +14 more
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Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer [PDF]
Breast Cancer Research, 2000 Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone replacement, and for fertility regulation. Certain compounds that act through the estrogen receptor (ER), now referred to as selective estrogen ...
S Katzenellenbogen, Benita +1 more
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