Results 11 to 20 of about 87,538 (117)

Estrogen/estrogen receptor alpha signaling in mouse posterofrontal cranial suture fusion. [PDF]

PLoS ONE, 2009
While premature suture fusion, or craniosynostosis, is a relatively common condition, the cause is often unknown. Estrogens are associated with growth plate fusion of endochondral bones.
Aaron W James, Alexander A Theologis, Samantha A Brugmann, Yue Xu, Antoine L Carre, Philipp Leucht, Katherine Hamilton, Kenneth S Korach, Michael T Longaker   +8 more
doaj   +1 more source

Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

Chemistry Central Journal, 2018
Background Cancer is at present one of the leading causes of death in the world. It accounts for 13% of deaths occurred worldwide and is continuously rising, with an estimated million of deaths up to 2030.
Deepika Sharma, Sanjiv Kumar, Balasubramanian Narasimhan   +2 more
doaj   +1 more source

Positive Regulation of Estrogen Receptor Alpha in Breast Tumorigenesis

Cells, 2021
Estrogen receptor alpha (ERα, NR3A1) contributes through its expression in different tissues to a spectrum of physiological processes, including reproductive system development and physiology, bone mass maintenance, as well as cardiovascular and central ...
Lucas Porras, Houssam Ismail, Sylvie Mader   +2 more
doaj   +1 more source

Autocrine regulation of cell proliferation by estrogen receptor-alpha in estrogen receptor-alpha-positive breast cancer cell lines

BMC Cancer, 2009
Background Estrogen receptor-α (ERα) is essential for mammary gland development and is a major oncogene in breast cancer. Since ERα is not colocalized with the cell proliferation marker Ki-67 in the normal mammary glands and the majority of primary ...
Pan Zhongzong, Zhong Yili, Tan Huining
doaj   +1 more source

AIB1/SRC-3/NCOA3 function in estrogen receptor alpha positive breast cancer

Frontiers in Endocrinology, 2023
The estrogen receptor alpha (ERα) is a steroid receptor that is pivotal in the initiation and progression of most breast cancers. ERα regulates gene transcription through recruitment of essential coregulators, including the steroid receptor coactivator ...
Amber J. Kiliti, Amber J. Kiliti, Ghada M. Sharif, Mary Beth Martin, Mary Beth Martin, Anton Wellstein, Anna T. Riegel   +6 more
doaj   +1 more source

Membrane-bound estrogen receptor alpha initiated signaling is dynamin dependent in breast cancer cells

European Journal of Medical Research, 2018
Background Although membrane-associated estrogen receptors (mERs) have been known to play important role in steroid-induced signal transmission, we still know little about their function in the estrogen-induced proliferation of breast cancer cells ...
Istvan Marczell, Petra Balogh, Gabor Nyiro, Anna L. Kiss, Balazs Kovacs, Gabor Bekesi, Karoly Racz, Attila Patocs   +7 more
doaj   +1 more source

VULCAN integrates ChIP-seq with patient-derived co-expression networks to identify GRHL2 as a key co-regulator of ERa at enhancers in breast cancer

Genome Biology, 2019
Background VirtUaL ChIP-seq Analysis through Networks (VULCAN) infers regulatory interactions of transcription factors by overlaying networks generated from publicly available tumor expression data onto ChIP-seq data.
Andrew N. Holding, Federico M. Giorgi, Amanda Donnelly, Amy E. Cullen, Sankari Nagarajan, Luke A. Selth, Florian Markowetz   +6 more
doaj   +1 more source

Expression of Estrogen Receptor Alpha in Malignant Melanoma

Advanced Biomedical Research, 2017
Background: Features of malignant melanoma (MM) vary in the different geographic regions of the world. This may be attributable to environmental, ethnic, and genetic factors.
Parvin Rajabi, Marzieh Bagheri, Mohsen Hani   +2 more
doaj   +1 more source

aP2-Cre-mediated inactivation of estrogen receptor alpha causes hydrometra.

PLoS ONE, 2014
In this study we describe the reproductive phenotypes of a novel mouse model in which Cre-mediated deletion of ERα is regulated by the aP2 (fatty acid binding protein 4) promoter.
Per Antonson, Marko Matic, Neil Portwood, Raoul V Kuiper, Galyna Bryzgalova, Hui Gao, Sara H Windahl, Patricia Humire, Claes Ohlsson, Per-Olof Berggren, Jan-Åke Gustafsson, Karin Dahlman-Wright   +11 more
doaj   +1 more source

Steroid-Functionalized Titanocenes: Docking Studies with Estrogen Receptor Alpha

Inorganics, 2016
Estrogen receptor alpha (ERα) is a transcription factor that is activated by hormones, with 17β-estradiol being its most active agonist endogenous ligand. ERα is also activated or inactivated by exogenous ligands. ER is overexpressed in hormone-dependent
Li Ming Gao, Wilson Maldonado, Xiomara Narváez-Pita, José A. Carmona-Negrón, Jesus Olivero-Verbel, Enrique Meléndez   +5 more
doaj   +1 more source