Results 11 to 20 of about 73,581 (158)

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis—Does Sex Matter? [PDF]

Metabolites, 2020
Christina Savva, Marion Korach-André
exaly   +2 more sources

Immunohistochemical Expression of Estrogen Receptor Beta in Urothelial Carcinoma of the Urinary Bladder

SVU - International Journal of Medical Sciences, 2023
Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by
Omnia M.M. Badawy *, Sabah Ahmed Mohamed, Ahmed Mahmoud Hassan , Ghada Hosny Mohamed   +3 more
doaj   +1 more source

Estrogen receptors alpha and beta in bone [PDF]

Bone, 2016
Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire   +2 more sources

Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2 [PDF]

Journal of Molecular Endocrinology, 2000
We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino acids inserted in the ligand binding domain of mERbeta1.
Lu, B., Leygue, E., Dotzlaw, H., Murphy, L. J., Murphy, L. C.   +4 more
openaire   +2 more sources

Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]

Seminars in Reproductive Medicine, 2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E., Cheng, You-Hong, Pavone, Mary Ellen, Xue, Qing, Attar, Erkut, Trukhacheva, Elena, Tokunaga, Hideki, Utsunomiya, Hiroki, Yin, Ping, Luo, Xia, Lin, Zhihong, Imir, Gonca, Thung, Stephen, Su, Emily J., Kim, J. Julie   +14 more
openaire   +4 more sources

Estrogen Signaling via Estrogen Receptor β [PDF]

Journal of Biological Chemistry, 2010
Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context.
Chunyan, Zhao, Karin, Dahlman-Wright, Jan-Åke, Gustafsson   +2 more
openaire   +2 more sources

Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells

BMC Cancer, 2017
Background Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.
Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck   +4 more
doaj   +1 more source

Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer [PDF]

Breast Cancer Research, 2000
Estrogens display intriguing tissue-selective action that is of great biomedical importance in the development of optimal therapeutics for the prevention and treatment of breast cancer, for menopausal hormone replacement, and for fertility regulation. Certain compounds that act through the estrogen receptor (ER), now referred to as selective estrogen ...
S Katzenellenbogen, Benita, A Katzenellenbogen, John   +1 more
openaire   +2 more sources