Results 11 to 20 of about 77,848 (254)

Coumestrol Alleviates Oxidative Stress, Apoptosis and Cognitive Impairments Through Hippocampal Estrogen Receptor-Beta in Male Mouse Model of Chronic Restraint Stress [PDF]

Pharmaceutical Sciences, 2022
Background: Coumestrol is well-known as a natural estrogen receptor-beta modulator. Since the role of estrogen receptors in controlling stressful situations has already been reported and their cognitive functions in hippocampus seem to be independent of ...
Kiarash Fekri, Javad Mahmoudi, Saeed Sadigh-Eteghad, Fereshteh Farajdokht, Alireza Mohajjel Nayebi   +4 more
doaj   +1 more source

Role of estrogen receptors in cancer: a special emphasis on the therapeutic potential of estrogen receptor β [PDF]

Pharmaceutical Sciences Asia, 2022
Estrogen receptors are nuclear receptors that play a major role in both physiology and pathology. Estrogen receptor subtypes are currently divided into three groups: estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), and G protein-coupled ...
Emdormi Rymbai, Deepa Sugumar, Dhritiman Roy, Divakar Selvaraj   +3 more
doaj   +1 more source

Cyclopia extracts act as selective estrogen receptor subtype downregulators in estrogen receptor positive breast cancer cell lines: Comparison to standard of care breast cancer endocrine therapies and a selective estrogen receptor agonist and antagonist

Frontiers in Pharmacology, 2023
Breast cancer is the most diagnosed type of cancer amongst women in economically developing countries and globally. Most breast cancers express estrogen receptor alpha (ERα) and are categorized as positive (ER+) breast cancer. Endocrine therapies such as,
Folasade R. Olayoku, Nicolette J. D. Verhoog, Ann Louw   +2 more
doaj   +1 more source

Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis—Does Sex Matter? [PDF]

Metabolites, 2020
Christina Savva, Korach-André Marion
exaly   +2 more sources

Immunohistochemical Expression of Estrogen Receptor Beta in Urothelial Carcinoma of the Urinary Bladder

SVU - International Journal of Medical Sciences, 2023
Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by
Omnia M.M. Badawy *, Sabah Ahmed Mohamed, Ahmed Mahmoud Hassan , Ghada Hosny Mohamed   +3 more
doaj   +1 more source

Expression of Estrogen Receptor Beta 2 in Laryngeal Cancer and Its Relationship with Lymph Node Metastasis

B-ENT, 2022
Objective: This study aimed to investigate the expression of estrogen receptor beta 2 receptor in laryngeal squamous cell carcinomas and its relationship with lymph node metastasis.
Elif Kaya Çelik, Ünsal Han, Murad Mutlu, Güleser Saylam, Kemal Keseroğlu, Ömer Bayır, Emel Çadallı Tatar, İstemihan Akın, Mehmet Hakan Korkmaz   +8 more
doaj   +2 more sources

Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2 [PDF]

Journal of Molecular Endocrinology, 2000
Abstract We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino acids inserted in the ligand binding domain of mERbeta1.
Lu, B., Leygue, E., Dotzlaw, H., Murphy, L. J., Murphy, L. C.   +4 more
openaire   +2 more sources

Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]

Seminars in Reproductive Medicine, 2010
Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E., Cheng, You-Hong, Pavone, Mary Ellen, Xue, Qing, Attar, Erkut, Trukhacheva, Elena, Tokunaga, Hideki, Utsunomiya, Hiroki, Yin, Ping, Luo, Xia, Lin, Zhihong, Imir, Gonca, Thung, Stephen, Su, Emily J., Kim, J. Julie   +14 more
openaire   +4 more sources

Estradiol via estrogen receptor beta influences ROS levels through the transcriptional regulation of SIRT3 in human seminoma TCam-2 cells

Tumor Biology, 2017
Human testis, gonocytes, and adult germ cells mainly express estrogen receptor beta, and estrogen receptor beta loss is associated with advanced tumor stage; however, the molecular mechanisms of estrogen receptor beta–protective effects are still to be ...
Salvatore Panza, Marta Santoro, Francesca De Amicis, Catia Morelli, Valentina Passarelli, Patrizia D’Aquila, Francesca Giordano, Erika Cione, Giuseppe Passarino, Dina Bellizzi, Saveria Aquila   +10 more
doaj   +1 more source

Effect of estrogen receptor β agonists on proliferation and gene expression of ovarian cancer cells

BMC Cancer, 2017
Background Estrogen receptor (ER) β has been suggested to affect ovarian carcinogenesis. We examined the effects of four ERβ agonists on proliferation and gene expression of two ovarian cancer cell lines.
Susanne Schüler-Toprak, Christoph Moehle, Maciej Skrzypczak, Olaf Ortmann, Oliver Treeck   +4 more
doaj   +1 more source