Results 11 to 20 of about 150,800 (299)
Estrogen receptor beta expression in prostate adenocarcinoma [PDF]
Diagnostic Pathology, 2011 Background Prostate cancer is the most commonly diagnosed cancer in men and the second leading cause of cancer death in men. Estrogen induction of cell proliferation is a crucial step in carcinogenesis of gynecologic target tissues, and there are many ...
Asgari Mojgan, Morakabati Arman
doaj +3 more sources
Estrogen rescues heart failure through estrogen receptor Beta activation [PDF]
Biology of Sex Differences, 2018 Background Recently, we showed that exogenous treatment with estrogen (E2) rescues pre-existing advanced heart failure (HF) in mice. Since most of the biological actions of E2 are mediated through the classical estrogen receptors alpha (ERα) and/or beta (
Andrea Iorga +9 more
doaj +5 more sources
Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis—Does Sex Matter? [PDF]
Metabolites, 2020 Christina Savva, Marion Korach-André
exaly +2 more sources
SVU - International Journal of Medical Sciences, 2023 Background: The tenth most prevalent cancer type in the world is bladder cancer. Males are four times more likely than females to have it. The most prevalent subtype is urothelial carcinoma. Development and progression of bladder cancer are influenced by
Omnia M.M. Badawy * +3 more
doaj +1 more source
Estrogen receptors alpha and beta in bone [PDF]
Bone, 2016 Estrogens are important for bone metabolism via a variety of mechanisms in osteoblasts, osteocytes, osteoclasts, immune cells and other cells to maintain bone mineral density. Estrogens bind to estrogen receptor alpha (ERα) and ERβ, and the roles of each of these receptors are beginning to be elucidated through whole body and tissue-specific knockouts ...
Aysha B. Khalid, Susan A. Krum
openaire +2 more sources
Functional characteristics of a novel murine estrogen receptor-beta isoform, estrogen receptor-beta 2 [PDF]
Journal of Molecular Endocrinology, 2000 We have isolated a highly expressed splice variant mRNA of murine estrogen receptor-beta (ERbeta), mERbeta2, containing an in-frame 54 nucleotide insertion between exons 5 and 6 of wild-type mERbeta1. The predicted ERbeta2 protein contains 18 amino acids inserted in the ligand binding domain of mERbeta1.
Lu, B. +4 more
openaire +2 more sources
A–C Estrogens as Potent and Selective Estrogen Receptor-Beta Agonists (SERBAs) to Enhance Memory Consolidation under Low-Estrogen Conditions [PDF]
, 2018 Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in postmenopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A–C estrogens, lacking the B and D estrogen rings ...
Donaldson, William A. +12 more
core +4 more sources
Estrogen Receptor-β, Estrogen Receptor-α, and Progesterone Resistance in Endometriosis [PDF]
Seminars in Reproductive Medicine, 2010 Loss of progesterone signaling in the endometrium may be a causal factor in the development of endometriosis, and progesterone resistance is commonly observed in women with this disease. In endometriotic stromal cells, the levels of progesterone receptor (PR), particularly the PR-B isoform, are significantly decreased, leading to a loss of paracrine ...
Bulun, Serdar E. +14 more
openaire +4 more sources
β-arrestin regulates estradiol membrane-initiated signaling in hypothalamic neurons. [PDF]
, 2015 Estradiol (E2) action in the nervous system is the result of both direct nuclear and membrane-initiated signaling (EMS). E2 regulates membrane estrogen receptor-α (ERα) levels through opposing mechanisms of EMS-mediated trafficking and internalization ...
Abrams, Matthew C +2 more
core +3 more sources
Estrogen Signaling via Estrogen Receptor β [PDF]
Journal of Biological Chemistry, 2010 Estrogens act by binding to and activating two estrogen receptors (ERs), ERα and ERβ. Transcriptional regulation by ERs is controlled by a complex array of factors such as ER-ligand binding, the DNA sequence bound by ERs, ER-interacting cofactors, and chromatin context.
Chunyan, Zhao +2 more
openaire +2 more sources