Results 211 to 220 of about 163,959 (310)

LOSS OF HETEROZYGOSITY OF THE ESTROGEN-RECEPTOR GENE IN BREAST-CANCER

, 1995
Hodgson, S, CG Mathew, Mathew, CG, JM Greenman, L Bobrow, Barnes, DM, H Iwase, Bobrow, L, Greenman, JM, S Hodgson, Iwase, H, DM Barnes   +11 more
core   +1 more source

Physiologically‐based pharmacokinetic modelling of uridine 5′‐diphosphoglucorosultransferase (UGT) substrate drugs in pregnant women

British Journal of Clinical Pharmacology, EarlyView.
Aims While pregnancy‐related changes in phase I enzyme activity are well‐documented, less is known about the impact on phase II enzymes. This study aimed to test the hypothesis that changes in the pharmacokinetics (PK) of uridine 5′‐diphosphoglucuronosyltransferase (UGT) substrates during pregnancy result from altered enzyme expression or activity ...
William Saffaf, Ymke van der Velde, Paul R. V. Malik, Jelmer R. Prins, Sanne J. Gordijn, Daan J. Touw, Paola Mian   +6 more
wiley   +1 more source

Molecular Insights into the Binding of Organophosphate Flame Retardant Key Metabolites with Mineralocorticoid and Estrogen Receptors. [PDF]

ACS Omega
Sumayya Tariq S, Sardar M, Shafiq M, Huzaifa M, Nur-E-Alam M, Wang Y, Ul-Haq Z.   +6 more
europepmc   +1 more source

PrEP at the site of action in cisgender and transgender women: A pharmacology study of blood and rectal CD4+ lymphocytes

British Journal of Clinical Pharmacology, EarlyView.
Background Female sex hormones used in feminizing hormone therapy (FHT) may influence activation and persistence of HIV pre‐exposure prophylaxis (PrEP) medications. The clinical relevance of this interaction remains unclear, particularly for transgender and cisgender women (TGW and CGW).
Elizabeth Hastie, Megha Srivasta, Edward R. Cachay, Leah Burke, Sara Gianella, Stephen Rawlings, Frank Z. Stanczyk, Craig Sykes, Angela D. M. Kashuba, Jill Blumenthal, Mackenzie L. Cottrell   +10 more
wiley   +1 more source

A comparative analysis of estrogen receptors, ACE2 and cytokines in pre-and postmenopausal women and men with COVID-19. [PDF]

Front Public Health
Lizarazo-Taborda MDR, Vega-Magaña N, Díaz-Palomera CD, Villegas-Pineda JC, Godínez-Rubí M, Bayardo-González RA, Ramírez-de-Arellano A, Pereira-Suárez AL.   +7 more
europepmc   +1 more source

Endogenous melatonin partial metabolic clearance as a potential endogenous marker of CYP1A2 activity

British Journal of Clinical Pharmacology, EarlyView.
Aims Cytochrome P450 1A2 (CYP1A2) exhibits substantial interindividual variability, necessitating appropriate phenotyping strategies for personalized pharmacotherapy. This study evaluated endogenous melatonin partial metabolic clearance (CLm(MEL)), calculated from urinary 6‐hydroxymelatonin (6‐O‐MEL) excretion and plasma melatonin (MEL) exposure, as a ...
Akitomo Yokokawa, Hayato Shimazaki, Shunji Igarashi, Yoshiki Tagawa, Naoki Hisada, Hiromi Shibasaki   +5 more
wiley   +1 more source

Early androgen activity after birth determines the hypothalamic expression of androgen and estrogen receptors in adulthood in female but not in male rats. [PDF]

Reprod Biol Endocrinol
García-Úbeda R, Fernandez-Garcia JM, Primo U, Grassi D, Ballesta A, Arevalo MA, Collado P, Pinos H, Carrillo B.   +8 more
europepmc   +1 more source

Risk of venous thromboembolism after SARS‐CoV‐2 vaccination—Evidence from genome‐wide association study and population‐based observational study

British Journal of Clinical Pharmacology, EarlyView.
Aim We aimed to investigate whether genetic variation is associated with venous thromboembolism after immunization with SARS‐CoV‐2 vaccines. Methods We conducted a genome‐wide association study (GWAS) on cases of venous thromboembolism within 42 days after SARS‐CoV‐2 vaccination, recruited from reports of adverse drug reactions sent to the Swedish ...
Sofia Attelind, Niclas Eriksson, Marco Cavalli, Yiyi Xu, Fredrik Nyberg, Anders Sundström, Mia Wadelius, Pär Hallberg   +7 more
wiley   +1 more source

Interaction between Estrogen Receptors and p53: A Broader Role for Tamoxifen?

Endocrinology
Das GM, Oturkar CC, Menon V.
europepmc   +1 more source

Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications. [PDF]

Aging Adv
Hinton A, Neikirk K, Le H, Harris C, Oliver A, Martin P, Gaye A.   +6 more
europepmc   +1 more source