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Estrogens, estrogen receptors and melanoma

Expert Review of Anticancer Therapy, 2011
The skin is the largest nonreproductive target tissue on which estrogen plays many beneficial and protective roles. Although neither exogenous hormones nor pregnancy represent significant risk factors for melanoma, epidemiological data suggest a higher survival rate in women with metastatic disease versus men and in premenopausal versus postmenopausal ...
Vincenzo De Giorgi   +8 more
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The Role of Estrogen and Estrogen Receptors in Chemoresistance

Current Medicinal Chemistry, 2011
Drug resistance is one of the major obstacles limiting the success of cancer chemotherapy. Biological mechanisms contributing to drug resistance may be present de novo and related to inherent features or may be raised after exposure to anticancer drugs. In recent years, both clinical observations and experimental studies suggested that steroid hormones
M, Sui, H, Zhang, W, Fan
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Biological Role of Estrogen and Estrogen Receptors

Critical Reviews in Biochemistry and Molecular Biology, 2002
(2002). Biological Role of Estrogen and Estrogen Receptors. Critical Reviews in Biochemistry and Molecular Biology: Vol. 37, No. 1, pp. 1-28.
Stefan, Nilsson, Jan-Ake, Gustafsson
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Estrogen and estrogen receptors in thyroid carcinomas

Journal of Surgical Oncology, 1991
AbstractThyroid tissues, composed of normal thyroid (10 cases), Graves' thyroid (4), and papillary carcinoma (10), were measured for the presence of receptors for estrogen (ER) using an enzyme‐immunoassay method. The mean value of ER in papillary carcinoma tissues (4.0 ± 3.6 fmol/mg protein) was higher than that in normal thyroid tissues (0.8 ± 0.4 ...
Y, Mizukami   +5 more
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Estrogen and estrogen receptors of breast cancer

Journal of Surgical Oncology, 1975
AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
V, Sahadevan   +3 more
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Estrogen receptors in the pancreas

Journal of Steroid Biochemistry, 1974
Minced rat pancreas retained a large portion of estradiol (E2) after incubation with either 5 nM or 1 μM concentrations of radioactive E2. The mince was homogenized in low salt buffer and separated into nuclei, mitochondria, microsomes, and cytosol by centrifugations at 1000 g, 10,000 g, and 105,000 g, respectively.
AVERY A. SANDBERG, HANNAH E. ROSENTHAL
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Estrogen receptor mutations

Molecular and Cellular Endocrinology, 1998
The purpose of this paper is to review potential novel functional pathways by which estradiol and estrogenic compounds elicit biological responses in mammals. We will limit our approach to those novel functions suggested by phenotypes associated with estrogen receptor-alpha (ER alpha) gene mutations and polymorphisms.
J A, Taylor, K J, Lewis, D B, Lubahn
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Estrogen or estrogen receptor?

Trends in Endocrinology & Metabolism, 2003
View Large Image | Download PowerPoint SlideAs a clinical breast oncologist, I was eager to review Endocrine Therapy in Breast Cancer. Hormonal manipulation has been the predominant form of breast cancer treatment for >50 years. Surgical ablation, high-dose estrogens, LHRH agonists and antiestrogens have all shown clinical benefit.
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