Results 181 to 190 of about 50,421 (294)

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

A heartfelt message, estrogen replacement therapy: use it or lose it.

Am J Physiol Heart Circ Physiol, 2018
Speth RC, D'Ambra M, Ji H, Sandberg K.
europepmc   +1 more source

Staging concept for aging management: Definition, mechanism, and coping strategies

VIEW, EarlyView.
We divided the overall aging stage into “pre‐aging”, “aging compensation”, and “aging disability”. For each stage, we delineate the clinical presentations, biological phenomena, theoretical underpinnings, and key management priorities. Abstract Aging, as a gradual and largely irreversible biological process, characterized by declining organismal ...
Zhonghan Wang, Shixian Liu, Shangyu Du, Xiangran Cui, Bo Chao, Minglei Liu, Minfei Wu   +6 more
wiley   +1 more source

Proteomic and metabolic signatures of female reproductive factors and risk of age‐related ocular diseases: A large prospective cohort study

VIEW, EarlyView.
The full editable vector source file of this graphical abstract is uploaded as a supplementary EPS file for typesetting. All elements are copyright‐free. Abstract Age‐related ocular diseases (ARODs), including cataract, primary open‐angle glaucoma (POAG), and age‐related macular degeneration (AMD), are leading causes of vision impairment and exhibit ...
Linge Jian, Zhiqian Huang, Keke Zhang, Jing Lin, Jia You, Yi Lu, Xiangjia Zhu   +6 more
wiley   +1 more source

ANGPT2 Drives Thyroid Cancer Progression Through PI3K/AKT Signaling and Correlates With Poor Prognosis and Immune Infiltration

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objectives Angiopoietin‐2 (ANGPT2) is known to participate in tumor progression and immune modulation across multiple malignancies. Nevertheless, its expression pattern, prognostic value, and biological function in thyroid cancer (THCA) have not been comprehensively investigated.
Han Chen, Lin Wang, Ji‐Sheng Zhang, Xu‐Dong Yan, Long‐Gang Yu, Yan Jiang   +5 more
wiley   +1 more source

Association Between Hormone Replacement Therapy and Incidence of Tendon Injuries and Surgical Repair in Perimenopausal Women: A Propensity Score-Matched National Cohort Study. [PDF]

Orthop J Sports Med
Bcharah G, Cancio-Bello A, Iturregui-Pastrana JM, Elsabbagh Z, Le Y, Nguyen C, Karsen PJ, Patel KA, Chhabra AS.   +8 more
europepmc   +1 more source

Prediction Models for Sentinel Lymph Node Metastasis in Clinically Node‐Negative Breast Cancer: Validation of Existing Nomograms, Model Development, and Ensemble Evaluation

World Journal of Surgery, EarlyView.
Prediction models using routine clinicopathological variables can identify patients with a very low risk of sentinel lymph node macrometastasis. Ensemble modeling modestly improves classification and increases the proportion of patients eligible for safe, risk‐adapted axillary de‐escalation.
Justin James, Kirti Mehta, Osamah Al‐Qershi, Emily Schembri, Michael Law, Shomik Sengupta, Christobel Saunders   +6 more
wiley   +1 more source

Transdermal Hormonal Therapy in Menopause: Current Evidence and Personalized Approaches. [PDF]

Pharmaceutics
Mihai MM, Toma AM, Toma CV, Copilău AI, Naum CI, Timofte MA, Văcăroiu IA, Stroescu AB, Sima RM, Poenaru MO.   +9 more
europepmc   +1 more source

Age-Related Increases in Benign Paroxysmal Positional Vertigo Are Reversed in Women Taking Estrogen Replacement Therapy: A Population-Based Study in Taiwan. [PDF]

Front Aging Neurosci, 2017
Liu DH, Kuo CH, Wang CT, Chiu CC, Chen TJ, Hwang DK, Kao CL.   +6 more
europepmc   +1 more source

Hormone Replacement Therapy Uptake and Discontinuation Trends From 1996‐2023: An Observational Study of the Welsh Population

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To analyse prescribing trends for oral and transdermal hormone replacement therapy (HRT) in Wales from 1996 to 2023, including predictors of discontinuation within one year of initiation. Design Observational study using the Secure Anonymised Information Linkage (SAIL) databank.
Robin Andrews, Arron Lacey, Kate Bache, Emma J. Kidd   +3 more
wiley   +1 more source