Results 181 to 190 of about 2,936,436 (245)

Hot flashes: a review. [PDF]

Front Med (Lausanne)
Jamal S, Elsabagh A, Wani L, Issa M.
europepmc   +1 more source

Intersection of systemic lupus erythematosus and autoimmune thyroid disease: Shared pathophysiology, epidemiology, diagnosis, and management

Rheumatology &Autoimmunity, EarlyView.
A proposed mechanistic framework of systemic lupus erythematosus (SLE) and autoimmune thyroid disease (AITD) pathogenesis. In Stage 1, genetically susceptible individuals harbor risk variants within major histocompatibility complex (HLA) and non‐HLA loci that impair central and peripheral immune tolerance mechanisms within the thymic and peripheral ...
Elisa Elisa, Awalia Awalia, Deasy Ardiany, Henry Sutanto   +3 more
wiley   +1 more source

Persistent Secondary Hypogonadism Following Chronic Opioid and Anabolic Steroid Exposure: A Case Report of Long-Term Testosterone Replacement Therapy and Its Complications. [PDF]

Cureus
Hollis E, Neamtu R, Sandoval A, Bruce K.
europepmc   +1 more source

Artificial intelligence empowers targeted protein degradation: Core technological innovations, multi‐scenario applications, and translational prospects

Smart Molecules, EarlyView.
AI is transforming TPD by improving the design, prediction, and optimization of degraders such as PROTACs, molecular glues, and LYTACs. This review summarizes key AI‐driven advances, highlights applications across drug discovery stages, and discusses remaining challenges and future directions for accelerating the development of therapies against ...
Shuanglin Qin, Rui Peng, Guangshuai Zhang, Si Yan, Jin Xiao, Zishu Liu, Ziyu Tan, Qingqing Xie, Shangjie Li, Wei Luo, Xiaohe Xiao   +10 more
wiley   +1 more source

Spontaneous conception and successful live birth during hormone replacement therapy in a patient with iatrogenic premature ovarian insufficiency: a case report. [PDF]

Front Med (Lausanne)
Lee JM, Yang JS, Park JE, Baek JC, Jo JY, Jo HC.   +5 more
europepmc   +1 more source

Single‐Vesicle Functional Nanophenotyping Reveals Heterogeneous PD‐L1 Accessibility in Triple‐Negative Breast Cancer

Small Methods, EarlyView.
Graphical Abstract. High‐speed atomic force microscopy enables real‐time, label‐free visualization of antibody interactions with individual extracellular vesicles. By quantifying binding frequency and dwell time, this approach reveals functional PD‐L1 accessibility that cannot be inferred from protein abundance alone, uncovering nanoscale heterogeneity
Reon Imakawa, Keesiang Lim, Takeshi Yoshida, Tomoyoshi Yamano, Tsunaki Hongu, Uryo Onishi, Masaharu Hazawa, Toshio Ando, Noriko Gotoh, Rikinari Hanayama, Richard W. Wong   +10 more
wiley   +1 more source

Long-term systemic outcomes of postmenopausal hormone replacement therapy by age at menopause: a real-world cohort study. [PDF]

Hum Reprod Open
Lu TF, Lu CH, Shih YH, Chen YF, Fan CT, Wang SJ, Hsu ST, Liu CK, Sun L, Hwang SF, Lee TH.   +10 more
europepmc   +1 more source

Environmental Mycotoxins and Brain Health: Protective Role of Bromelain Against Fumonisin B1 in SH‐SY5Y Cells

Environmental Toxicology, EarlyView.
ABSTRACT Fumonisin B1 (FB1), a mycotoxin commonly found in contaminated food and feed, has been increasingly implicated in neurotoxicity, although its mechanisms remain poorly understood. This study investigates the neurotoxic potential of FB1 in human SH‐SY5Y neuroblastoma cells, both undifferentiated and RA‐differentiated, and evaluates the ...
Gianluca Antonio Franco, Francesca Inferrera, Nicla Tranchida, Davide Di Paola, Roberta Fusco, Salvatore Cuzzocrea, Enrico Gugliandolo   +6 more
wiley   +1 more source

Long-Term Oncological Implications of Hormone Replacement Therapy in Women With Hypogonadotropic Hypogonadism: A Propensity-Matched Study. [PDF]

Cureus
Eidbo S, Nana M, King S, Barnett M, Mayo R.   +4 more
europepmc   +1 more source

Adrenal insufficiency after long-term high-dose ethinylestradiol use in a transgender woman. [PDF]

JCEM Case Rep
Aoki N, Taguchi T, Oda S, Tadokoro S, Ichikawa R, Miyatsuka T.   +5 more
europepmc   +1 more source