Results 21 to 30 of about 4,921 (204)

Local modulation of steroid action: rapid control of enzymatic activity

Frontiers in Neuroscience, 2015
Estrogens can induce rapid, short-lived physiological and behavioral responses, in addition to their slow, but long-term, effects at the transcriptional level.
Thierry D Charlier, Charlotte A Cornil, Christine ePatte-Mensah, Laurence eMeyer, A Guy Mensah-Nyagan, Jacques eBalthazart   +5 more
doaj   +1 more source

Molecular, Enzymatic, and Cellular Characterization of Soluble Adenylyl Cyclase From Aquatic Animals. [PDF]

, 2018
The enzyme soluble adenylyl cyclase (sAC) is the most recently identified source of the messenger molecule cyclic adenosine monophosphate. sAC is evolutionarily conserved from cyanobacteria to human, is directly stimulated by [Formula: see text] ions ...
Acin-Perez, Barott, Barott, Barott, Beltrán, Berthelot, Bitterman, Bordeaux, Braun, Braun, Braun, Buck, Camacho Londoño, Chaloupka, Chen, Chen, Cooper, De Rasmo, Di Benedetto, Elliott, Farrell, Geng, Goldberg, Gordeladze, Hess, Hrdlickova, Jaiswal, Kobayashi, Leparc, Levin, Litvin, Magro, Neer, Neer, Nomura, Nomura, Ramos-Espiritu, Roa, Roa, Roa, Salem, Salomon, Schwencke, Steegborn, Steegborn, Stessin, Structural Genomics Consortium, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Tresguerres, Wilson, Yeo, Zaccolo, Zippin, Zippin, Zippin, Zippin   +58 more
core   +2 more sources

Cancer morbidity in rheumatoid arthritis: role of estrogen metabolites [PDF]

, 2013
Estrogen metabolites have been implicated in rheumatoid arthritis (RA) and cancer, although the mechanism remains unestablished. Some estrogen metabolites, which are used for the assessment of cancer risk, play an important role in RA.
Khan, Mohd Wajid Ali Khan, Khan, Wahid Ali   +1 more
core   +4 more sources

Estrogen Exposure, Metabolism, and Enzyme Variants in a Model for Breast Cancer Risk Prediction

Cancer Informatics, 2009
Estrogen is a well-known risk factor for breast cancer. Current models of breast cancer risk prediction are based on cumulative estrogen exposure but do not directly reflect mammary estrogen metabolism or address genetic variability between women in ...
Fritz F. Parl, Kathleen M. Egan, Chun Li, Philip S. Crooke   +3 more
doaj   +2 more sources

Discovery of breast cancer risk genes and establishment of a prediction model based on estrogen metabolism regulation

BMC Cancer, 2021
Background Multiple common variants identified by genome-wide association studies have shown limited evidence of the risk of breast cancer in Chinese individuals. In this study, we aimed to uncover the relationship between estrogen levels and the genetic
Feng Zhao, Zhixiang Hao, Yanan Zhong, Yinxue Xu, Meng Guo, Bei Zhang, Xiaoxing Yin, Ying Li, Xueyan Zhou   +8 more
doaj   +1 more source

Sex steroids, carcinogenesis, and cancer progression [PDF]

, 2004
The relationship between sex steroids and cancer has been studied for more than a century. Using an original intact cell analysis, we investigated sex steroid metabolism in a panel of human cancer cell lines, either hormone responsive or unresponsive ...
Agostara, B., BRONTE, Giuseppe, CAMPISI, Ildegarda, CARRUBA, Giuseppe, CASTAGNETTA, Luigi, COCCIADIFERRO, Letizia, Granata, O., Polito, L., RIZZO, Sergio, SAETTA, Annalisa   +9 more
core   +1 more source

Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients. [PDF]

PLoS ONE, 2012
BackgroundEndogenous estrogens play an important role in the overall cardiocirculatory system. However, there are no studies exploring the hormone metabolism and signaling pathway genes together on ischemic stroke, including sulfotransferase family 1E ...
Yi-Chen Hsieh, Jiann-Shing Jeng, Huey-Juan Lin, Chaur-Jong Hu, Chia-Chen Yu, Li-Ming Lien, Giia-Sheun Peng, Chin-I Chen, Sung-Chun Tang, Nai-Fang Chi, Hung-Pin Tseng, Chang-Ming Chern, Fang-I Hsieh, Chyi-Huey Bai, Yi-Rhu Chen, Hung-Yi Chiou, Formosa Stroke Genetic Consortium   +16 more
doaj   +1 more source

Detection and Characterization of Catechol Quinone-Derived Protein Adducts Using Biomolecular Mass Spectrometry

Frontiers in Chemistry, 2019
The catechol quinone (CQ) motif is present in many biologically relevant molecules throughout endogenous metabolic products, foods, drugs, and environmental pollutants. The CQ derivatives may undergo Michael addition, and has been shown to yield covalent
Shu-Hui Chen, Chun-Wei Li
doaj   +1 more source

Polymorphisms in genes involved in the estrogen pathway and mammographic density [PDF]

, 2010
Background Single nucleotide polymorphisms (SNPs) in genes involved in the estrogen pathway appear to be associated with breast cancer risk and possibly with mammographic density (MD), but little is known of these associations among premenopausal women ...
Isabelle Dumas, Caroline Diorio
core   +1 more source

The Association of the COMT V158M Polymorphism with Endometrial/Ovarian Cancer in HNPCC Families Adhering to the Amsterdam Criteria

Hereditary Cancer in Clinical Practice, 2006
Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). The Met
Ashton Katie A, Meldrum Cliff J, McPhillips Mary L, Suchy Janina, Kurzawski Grzegorz, Lubinski Jan, Scott Rodney J   +6 more
doaj   +1 more source