Results 31 to 40 of about 4,921 (204)

Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland [PDF]

, 2010
Extensive data suggest that estradiol contributes to the development of breast cancer by acting as a mitogen and exerting direct genotoxic effects after enzymatic conversion to 4-hydroxyestradiol (4-OHE2) via cytochrome P450 1B1 (CYP1B1).
Aiyar, Sarah E., Atkins, Kristen A., Cavalieri, Ercole L., Kim, Sanghee, Kim, Taehyun, Mohammad, Khalid S. Mohammad, Park, Hoyong, Rogan, Eleanor G., Santen, Richard J., Wang, Ji-Ping, Yue, Wei, Zhang, Zhenguo   +11 more
core   +1 more source

Sex Hormone-Related Functions in Regenerating Male Rat Liver [PDF]

, 1986
Sex hormone receptors were quantitated in normal male rat liver and in regenerating liver at several different times after partial (70%) hepatectomy. Both estrogen and androgen receptor content were altered dramatically by partial hepatectomy.
Aquilino, AM, DiLeo, A, Eagon, PK, Francavilla, A, Ingrosso, M, Panella, C, Polimeno, L, Starzl, TE, Van Thiel, DH   +8 more
core   +1 more source

COMT and MAO-A Polymorphisms and Obsessive-Compulsive Disorder: A Family-Based Association Study [PDF]

, 2015
ObjectiveObsessive-compulsive disorder (OCD) is a common and debilitating psychiatric illness. Although a genetic component contributes to its etiology, no single gene or mechanism has been identified to the OCD susceptibility.
Arnold, Paul, Braganca Pereira, Carlos Alberto de, Cappi, Carolina, Fargeness, Jesen, Fontenelle, Leonardo, Hanna, Gregory L., Hounie, Ana Gabriela, Kennedy, James, Mathews, Carol, Miguel, Euripedes Constantino, Morais, Ivanil, Pauls, David L., Petribu, Katia, Richter, Margaret, Rosario, Maria Conceição do, Sampaio, Aline Santos, Stewart, S. Evelyn, Vallada, Homero   +17 more
core   +9 more sources

Is there a causal association between genotoxicity and the imposex effect? [PDF]

, 2006
There is a growing body of evidence that indicates common environmental pollutants are capable of disrupting reproductive and developmental processes by interfering with the actions of endogenous hormones.
Josephine A. Hagger, Michael H. Depledge, Jörg Oehlmann, Susan Jobling, Tamara S. Galloway, Colborn T, Collins MKL, Cooke H, Depledge MH, Gibbs PE, Harring KE, Harris JO, Laruelle F, Smith BS   +13 more
core   +2 more sources

The serotonin transporter promotes a pathological estrogen metabolic pathway in pulmonary hypertension via cytochrome P450 1B1 pulmonary circulation [PDF]

, 2016
Pulmonary arterial hypertension (PAH) is a devastating vasculopathy that predominates in women and has been associated with dysregulated estrogen and serotonin signaling. Overexpression of the serotonin transporter (SERT+) in mice results in an estrogen-
Anagnostopoulou, Aikaterini, Dean, Afshan, Hood, Katie, Johansen, Anne Katrine Z., Loughlin, Lynn, MacLean, Margaret R., Morecroft, Ian, Nilsen, Margaret, Touyz, Rhian M., White, Kevin   +9 more
core   +1 more source

Mechanisms of genotoxic effects of hormones [PDF]

, 2002
A concept that compounds commonly present in biological systems lack genotoxic and mutagenic activities is generally in use, hence a low number of endogenous substances have ever been tested to mutagenicity.
Đelić Ninoslav J.
core   +1 more source

Schistosoma haematobium and bladder cancer: what lies beneath? [PDF]

, 2010
Schistosoma haematobium is a parasitic flatworm that infects millions of people, mostly in the developing world, and is associated with high incidence of bladder cancer although why is not clear.
Botelho, Mónica Catarina, Costa, José Manuel Correia da, Machado, José Carlos   +2 more
core   +1 more source

Beyond “you are what you eat”: Unlocking gut microbiota‐mediated biotransformation of dietary phytochemicals

iMetaOmics, EarlyView.
The “efficacy paradox” of phytochemicals, low bioavailability yet significant health benefits, is associated with gut microbiota, which biotransforms dietary precursors into bioactive metabolites, enabling systemic effects. Thus, health outcomes of diet depend not just on intake “the rainbow”, but on gut microbial metabolism, redefining “you are what ...
Peng Yang, Ren‐You Gan
wiley   +1 more source

Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk

BMC Cancer, 2008
Background Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts catechol estrogens into biologically ...
Knight Julia A, Briollais Laurent, Aaltonen Kirsimari, Onay Ummiye V, Pabalan Noel, Kilpivaara Outi, Andrulis Irene L, Blomqvist Carl, Nevanlinna Heli, Ozcelik Hilmi   +9 more
doaj   +1 more source

Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source