Results 31 to 40 of about 319,930 (224)
Mechanisms of genotoxic effects of hormones [PDF]
, 2002 A concept that compounds commonly present in biological systems lack genotoxic and mutagenic activities is generally in use, hence a low number of endogenous substances have ever been tested to mutagenicity.
Đelić Ninoslav J.
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Hereditary Cancer in Clinical Practice, 2006 Catechol-O-methyltransferase (COMT) is vital for the conjugation of catechol estrogens that are produced during oestrogen metabolism. The efficiency of this process varies due to a polymorphism in COMT, which changes valine to methionine (V158M). The Met
Ashton Katie A +6 more
doaj +1 more source
Sex steroids, carcinogenesis, and cancer progression [PDF]
, 2004 The relationship between sex steroids and cancer has been studied for more than a century. Using an original intact cell analysis, we investigated sex steroid metabolism in a panel of human cancer cell lines, either hormone responsive or unresponsive ...
Agostara, B. +9 more
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The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions [PDF]
Journal of Endocrinology, 2000 Recent data indicate that the catechol estrogen, 2-hydroxyestrone (2-OHE(1)), has no effect on any target tissue including bone, whereas 16 alpha-hydroxyestrone (16 alpha-OHE(1)) exerts tissue-selective estrogen agonist activity. The effect of the catechol estrogen, 4-hydroxyestrone (4-OHE(1)), putatively associated with tumorigenesis, has not been ...
K C, Westerlind +3 more
openaire +2 more sources
Tetra-methoxystilbene modulates ductal growth of the developing murine mammary gland [PDF]
, 2010 Extensive data suggest that estradiol contributes to the development of breast cancer by acting as a mitogen and exerting direct genotoxic effects after enzymatic conversion to 4-hydroxyestradiol (4-OHE2) via cytochrome P450 1B1 (CYP1B1).
Aiyar, Sarah E. +11 more
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Is there a causal association between genotoxicity and the imposex effect? [PDF]
, 2007 There is a growing body of evidence that indicates common environmental pollutants are capable of disrupting reproductive and developmental processes by interfering with the actions of endogenous hormones.
Depledge, Michael H. +4 more
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Assessment of Cellular Estrogenic Activity Based on Estrogen Receptor-Mediated Reduction of Soluble-Form Catechol-O-Methyltransferase (COMT) Expression in an ELISA-Based System [PDF]
, 2013 published_or_final_versio
Ho, SL +7 more
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Experimental Physiology, EarlyView.Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi +5 more
wiley +1 more source
Combined effect of CCND1 and COMT polymorphisms and increased breast cancer risk
BMC Cancer, 2008 Background Estrogens are crucial tumorigenic hormones, which impact the cell growth and proliferation during breast cancer development. Estrogens are metabolized by a series of enzymes including COMT, which converts catechol estrogens into biologically ...
Knight Julia A +9 more
doaj +1 more source
Journal of the Science of Food and Agriculture, Volume 106, Issue 4, Page 2180-2189, 15 March 2026.Abstract BACKGROUND Plant‐lignans are polyphenols with low bioavailability and bioactivity that are transformed by the intestinal microbiota into enterolignans. Our hypotheses are: (i) the way in which plant‐lignans are ingested in the diet affects, in a decisive way, the microbial metabolism of these compounds and (ii) an increase in lignan ...
Susana Langa +4 more
wiley +1 more source