Results 171 to 180 of about 138,106 (224)
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Testicular toxicity and mutagenicity of steroidal and non-steroidal estrogens in the male mouse
Mutation Research/Genetic Toxicology, 1991The mutagenicity and toxicity of diethylstilbestrol (DES), 17 beta-estradiol and zeranol on the male mouse germ cells were investigated with meiotic micronucleus assays in vivo and in vitro, sperm-head abnormality test and morphometry. Further, the developmental effects of DES on testicular morphology were explored.
L, Pylkkänen +3 more
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Current Medicinal Chemistry, 2010
Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural
T, Lóránd, E, Vigh, J, Garai
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Herbivorous and omnivorous vertebrates have evolved in the presence of a variety of phytoestrogens, i.e., plant-derived compounds that can mimic, modulate or disrupt the actions of endogenous estrogens. Since the discovery of the estrus-inducing effects of some plant products in 1926, considerable effort has been devoted to the isolation and structural
T, Lóránd, E, Vigh, J, Garai
openaire +3 more sources
Rapid Communications in Mass Spectrometry, 2002
Abstract It is suspected that all the natural estrogens occurring in the human body, as well as dietary and synthetic estrogens, diversely affect the endocrine system depending on their exposure patterns. More rapid, reliable and accurate measurements of these compounds in various biological matrices are thus ...
Man Ho, Choi +4 more
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Abstract It is suspected that all the natural estrogens occurring in the human body, as well as dietary and synthetic estrogens, diversely affect the endocrine system depending on their exposure patterns. More rapid, reliable and accurate measurements of these compounds in various biological matrices are thus ...
Man Ho, Choi +4 more
openaire +3 more sources
Endocrinology, 1958
MER-25, l-(p-2-Diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenyl ethanol, blocks the response of estrogen target organs to the stimulating action of estrogens. The estrogen antagonism activity of MER-25 has been demonstrated in intact and castrate rats, mice and monkeys and in chicks and rabbits.
LEONARD J. LERNER +2 more
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MER-25, l-(p-2-Diethylaminoethoxyphenyl)-l-phenyl-2-p-methoxyphenyl ethanol, blocks the response of estrogen target organs to the stimulating action of estrogens. The estrogen antagonism activity of MER-25 has been demonstrated in intact and castrate rats, mice and monkeys and in chicks and rabbits.
LEONARD J. LERNER +2 more
openaire +2 more sources
Early-estrogen syndrome in the rat by the non-steroidal estrogen diethylstilbestrol
Experientia, 1967Typisches, durch Ostrogene (fruhpostnatale Periode) bei weiblichen und mannlichen Ratten induziertes Syndrom, wird auch durch nicht-steroidales Ostrogen, das Diathylstilbostrol, ausgelost. Auffallend wellenformige Granulosazellenschicht in den grossen Graafschen Follikeln.
J, Presl +3 more
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Developmental evaluation of a potential non-steroidal estrogen: triclosan
Marine Environmental Research, 2000Triclosan is an antibacterial agent commonly used in industry and often detected in waste-water effluent. The potential of triclosan to act as an endocrine disruptor was examined because its chemical structure closely resembles known non-steroidal estrogens (e.g. DES, bisphenol A).
C M, Foran, E R, Bennett, W H, Benson
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Current Computer-Aided Drug Design, 2023
Background:Breast cancer is one of the most commonly diagnosed cancer types among women worldwide. Cytochrome P450 aromatase (CYP19A1) is an enzyme in vertebrates that selectively catalyzes the biosynthesis of estrogens from androgenic precursors. Researchers have increasingly focused on developing non-steroidal aromatase inhibitors (NSAIs) for their ...
Khushboo Pandey +5 more
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Background:Breast cancer is one of the most commonly diagnosed cancer types among women worldwide. Cytochrome P450 aromatase (CYP19A1) is an enzyme in vertebrates that selectively catalyzes the biosynthesis of estrogens from androgenic precursors. Researchers have increasingly focused on developing non-steroidal aromatase inhibitors (NSAIs) for their ...
Khushboo Pandey +5 more
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Urban Water Journal, 2021
The present study reports for the first time the occurrence of selected pharmaceuticals and personal care products (PPCPs) in the shallow aquifer underlying the Kraków city.
Piotr Rusiniak +4 more
semanticscholar +1 more source
The present study reports for the first time the occurrence of selected pharmaceuticals and personal care products (PPCPs) in the shallow aquifer underlying the Kraków city.
Piotr Rusiniak +4 more
semanticscholar +1 more source
The synthesis of non-steroidal estrogen receptor binding compounds labeled with 80mBr
International Journal of Radiation Applications and Instrumentation. Part B. Nuclear Medicine and Biology, 1986Estrogen receptor (ER) binding radiopharmaceuticals have potential for use in the diagnosis and treatment of cancers of the female reproductive system. Two triphenylethylene derivatives based on the structure of hydroxytamoxifen 4, a high ER binding metabolite of tamoxifen 5, have been prepared: 1-(4-dimethylaminoethoxy)phenyl]-1-(4-hydroxy)phenyl-2 ...
R H, Seevers +3 more
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Development of Steroidal Aromatase Inhibitors as Potential Anti-breast Cancer Agents
, 2020Breast cancer is the most prevalent type of cancer and one of the leading causes of death among all the cancers affecting women worldwide. Preliminary cause of development of tumors in the breast cancer in post-menopausal women is mostly the increased ...
Rahul B. Ghuge +6 more
semanticscholar +1 more source