Results 191 to 200 of about 5,290 (236)
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Journal of Steroid Biochemistry, 1987
Estrone (E1), estradiol (E2), the catechol estrogens 2-OHE1 and 2-OHE2, and diethylstilbestrol (DES) were incubated with purified prostaglandin synthase (PHS) in vitro in the presence of arachidonic acid and their PHS-catalyzed cooxidation was determined.
G H, Degen +3 more
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Estrone (E1), estradiol (E2), the catechol estrogens 2-OHE1 and 2-OHE2, and diethylstilbestrol (DES) were incubated with purified prostaglandin synthase (PHS) in vitro in the presence of arachidonic acid and their PHS-catalyzed cooxidation was determined.
G H, Degen +3 more
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The Journal of Steroid Biochemistry and Molecular Biology, 1990
CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 micrograms/kg p.o.), CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 microM with an IC50 of 0.02 microM and does not significantly affect progesterone production up to ...
A S, Bhatnagar +4 more
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CGS 20267 is a new non-steroidal compound which potently inhibits aromatase in vitro (IC50 of 11.5 nM) and in vivo (ED50 of 1-3 micrograms/kg p.o.), CGS 20267 maximally inhibits estradiol production in vitro in LH-stimulated hamster ovarian tissue at 0.1 microM with an IC50 of 0.02 microM and does not significantly affect progesterone production up to ...
A S, Bhatnagar +4 more
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ChemInform Abstract: The Synthesis of New Platinum(II) Complexes Linked to Non‐Steroidal Estrogens.
ChemInform, 1993AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
P. WHEELER, G. BERUBE
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Chemischer Informationsdienst, 1986
AbstractThe iodosobenzenes generated by treating (II) with Na2CO3 react with (I) to provide the iodoniumylides (III), whose thermal rearrangement to (IV) followed by reductive deiodination yields (V).
F. A. A. EL‐MARIAH, T. KAPPE
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AbstractThe iodosobenzenes generated by treating (II) with Na2CO3 react with (I) to provide the iodoniumylides (III), whose thermal rearrangement to (IV) followed by reductive deiodination yields (V).
F. A. A. EL‐MARIAH, T. KAPPE
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Bioorganic & Medicinal Chemistry Letters, 1997
Abstract A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effects as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain.
Sachi Tripathi +4 more
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Abstract A piperidinoethoxy substituent in non-steroidal antiestrogens has a relatively higher antiestrogenic effects as compared to a pyrrolidinoethoxy moiety. However, the antagonistic activity is more depended on the molecular geometry than the nature of the basic chain.
Sachi Tripathi +4 more
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Experientia, 1973
Des disperisions aqueuses de progestogenes et estrogenes stimulent l'agregation des plaquettes de cobaye produites par ADP in vitro. Le diethylstilbesterol et l'hexestrol qui ne sont pas des steroides, mais possedent une activite estrogenique, ont un effet inhibitoire sur l'agregation.
S, Clayman, R E, Gadd, D, Hébert
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Des disperisions aqueuses de progestogenes et estrogenes stimulent l'agregation des plaquettes de cobaye produites par ADP in vitro. Le diethylstilbesterol et l'hexestrol qui ne sont pas des steroides, mais possedent une activite estrogenique, ont un effet inhibitoire sur l'agregation.
S, Clayman, R E, Gadd, D, Hébert
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Non-steroidal anti-estrogens in the treatment of breast cancer.
Current opinion in investigational drugs (London, England : 2000), 2007The non-steroidal selective estrogen receptor modulator (SERM) tamoxifen has been used as standard first-line therapy for postmenopausal breast cancer since the 1970s, during which time over 400,000 lives have been saved. Nevertheless, much attention has been paid to the side effect profile of tamoxifen, particularly in terms of cardiovascular and ...
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Non Steroidal Estrogen Antagonists: Current Status and Future Perspectives
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents, 2001Bentham Science Publisher K. Hajela +2 more
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