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Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists.
Franzi, Elisa +7 more
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The fate of steroid estrogens: Partitioning during wastewater treatment and onto river sediments [PDF]
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2010 Springer Science+Business Media B.V.The partitioning of steroid estrogens in wastewater treatment and receiving waters is likely to ...
Scrimshaw, Mark D. +11 more
core +1 more source
Structure–activity studies of non-steroid analogues structurally-related to neuroprotective estrogens [PDF]
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury.
Mingxing, Qian +5 more
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Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands [PDF]
AbstractThe importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core elements by preparing selenium‐containing heterocycles and exploring the activities of ...
Silong, Zhang +10 more
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Anastrozole is a selective non-steroidal aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues. It is used as adjuvant therapy for early-stage hormone-sensitive breast cancer in postmenopausal women.
Petr Potmešil, Radka Szotkowská
doaj +1 more source
Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. [PDF]
In this article we report a simple and efficient method for detecting nonsteroidal estrogens in a biologic sample. This method uses polyclonal antibodies to estradiol (E2) to immunoprecipitate these major biologically active steroidal estrogens, leaving ...
Lasley, Bill L +15 more
core +1 more source
Mechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and
Rosa Muñoz-Cano +12 more
doaj +1 more source
Screening and risk management solutions for steroidal estrogens in surface and wastewater [PDF]
Background: The European Commission Implementing Decision EU 2015/495 included three steroidal estrogens, namely 17α-ethinyl estradiol, 17β-estradiol, and estrone, in the so-called “watch list” of the EU Water Framework Directive (WFD). The monitoring of
Marneffe Y. +35 more
core +2 more sources
OBJETIVOS: avaliar a eficácia do uso de isoflavonas da soja no tratamento de sintomas depressivos em mulheres com síndrome climatérica. MÉTODOS: estudo experimental placebo-controlado, randomizado e duplo-cego, com 84 pacientes climatéricas atendidas ...
Rilva Lopes de Sousa +4 more
doaj +1 more source
Inhibition of Human Phenol and Estrogen Sulfotransferase by Certain Non-Steroidal Anti-Inflammatory Agents [PDF]
We hypothesized that aryl acetate- and aryl carboxylate-containing drugs would inhibit human phenol sulfotransferase (SULT1A1), and that selectivity would depend upon the interaction of the aryl portion of the molecule with the sulfotransferase acceptor binding site. This hypothesis was based on results with the rat orthologue showing that oxidation of
King, Roberta S., Ghosh, A., Wu, Jinfang
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