Results 11 to 20 of about 5,290 (236)

Drug-induced liver injury after switching from tamoxifen to anastrozole in a patient with a history of breast cancer being treated for hypertension and diabetes

Therapeutic Advances in Chronic Disease, 2020
Anastrozole is a selective non-steroidal aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues. It is used as adjuvant therapy for early-stage hormone-sensitive breast cancer in postmenopausal women.
Petr Potmešil, Radka Szotkowská
doaj   +1 more source

Mechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis

Frontiers in Immunology, 2017
Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and
Rosa Muñoz-Cano, Rosa Muñoz-Cano, Mariona Pascal, Mariona Pascal, Giovanna Araujo, Giovanna Araujo, M. J. Goikoetxea, Antonio L. Valero, Antonio L. Valero, Cesar Picado, Cesar Picado, Joan Bartra, Joan Bartra   +12 more
doaj   +1 more source

Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion

International Journal of Molecular Sciences, 2023
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists.
Franzi, Elisa, Mathez, Gregory, Dinant, Soraya, Deloizy, Charlotte, Kaiser, Laurent, Tapparel, Caroline, Le Goffic, Ronan, Cagno, Valeria   +7 more
openaire   +3 more sources

Ensaio clínico placebo-controlado com isoflavonas da soja para sintomas depressivos em mulheres no climatério Placebo-controlled clinical trial with soy isoflavones for depressive symptoms in climacteric women

Revista Brasileira de Ginecologia e Obstetrícia, 2006
OBJETIVOS: avaliar a eficácia do uso de isoflavonas da soja no tratamento de sintomas depressivos em mulheres com síndrome climatérica. MÉTODOS: estudo experimental placebo-controlado, randomizado e duplo-cego, com 84 pacientes climatéricas atendidas ...
Rilva Lopes de Sousa, Rosália Gouveia Filizola, Margareth de Fátima Formiga Melo Diniz, Eduardo Sérgio Soares Sousa, João Leonardo Ribeiro de Moraes   +4 more
doaj   +1 more source

Structure–activity studies of non-steroid analogues structurally-related to neuroprotective estrogens [PDF]

Organic & Biomolecular Chemistry, 2016
Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury.
Mingxing, Qian, Elizabeth B, Engler-Chiurazzi, Sara E, Lewis, Nigam P, Rath, James W, Simpkins, Douglas F, Covey   +5 more
openaire   +2 more sources

Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands [PDF]

ChemMedChem, 2017
AbstractThe importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core elements by preparing selenium‐containing heterocycles and exploring the activities of ...
Silong, Zhang, Zhiyong, Wang, Zhiye, Hu, Changhao, Li, Chu, Tang, Kathryn E, Carlson, Junjie, Luo, Chune, Dong, John A, Katzenellenbogen, Jian, Huang, Hai-Bing, Zhou   +10 more
openaire   +2 more sources

Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs

Molecules
Aromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer.
Sara Janowska, Serhii Holota, Roman Lesyk, Monika Wujec   +3 more
doaj   +1 more source

OSTEOARTHRITIS IN WOMEN: ARE THERE ANY DIFFERENCES? Review

Медична наука України, 2019
Relevance. Female gender is known to be a major risk factor for osteoarthritis (OA). In addition, women with OA are characterized by some differences in the context of etiopathogenesis, clinical course and prognosis, and the question of clarifying the ...
O.B. Iaremenko, D.I. Koliadenko
doaj   +1 more source

Inhibition of Human Phenol and Estrogen Sulfotransferase by Certain Non-Steroidal Anti-Inflammatory Agents [PDF]

Current Drug Metabolism, 2006
We hypothesized that aryl acetate- and aryl carboxylate-containing drugs would inhibit human phenol sulfotransferase (SULT1A1), and that selectivity would depend upon the interaction of the aryl portion of the molecule with the sulfotransferase acceptor binding site. This hypothesis was based on results with the rat orthologue showing that oxidation of
King, Roberta S., Ghosh, A., Wu, Jinfang
openaire   +3 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source