Structure–activity studies of non-steroid analogues structurally-related to neuroprotective estrogens [PDF]
Organic & Biomolecular Chemistry, 2016 Estrone and 17β-estradiol are phenolic steroids that are known to be neuroprotective in multiple models of neuronal injury.
Mingxing, Qian +5 more
openaire +2 more sources
Environmental Factors in the Relapse and Recurrence of Inflammatory Bowel Disease:A Review of the Literature [PDF]
, 2015 The causes of relapse in patients with Crohn's disease (CD) and ulcerative colitis (UC) are largely unknown. This paper reviews the epidemiological and clinical data on how medications (non-steroidal anti-inflammatory drugs, estrogens and antibiotics ...
A Bitton +99 more
core +1 more source
International Journal of Molecular Sciences, 2023 Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists.
Franzi, Elisa +7 more
openaire +3 more sources
Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances [PDF]
, 2006 International audienceAromatase, a key steroidogenic enzyme that catalyses the conversion of androgens to estrogens, represent a target for endocrine disrupting chemicals.
Brion, François +2 more
core +3 more sources
Endocrine disruptors in bottled mineral water : total estrogenic burden and migration from plastic bottles [PDF]
, 2009 Background, aim, and scope Food consumption is an important route of human exposure to endocrine-disrupting chemicals. So far, this has been demonstrated by exposure modeling or analytical identification of single substances in foodstuff (e.g ...
Oehlmann, Jörg, Wagner, Martin
core +1 more source
A Novel Prodrug Approach for Central Nervous System-Selective Estrogen Therapy
Molecules, 2019 Beneficial effects of estrogens in the central nervous system (CNS) results from the synergistic combination of their well-orchestrated genomic and non-genomic actions, making them potential broad-spectrum neurotherapeutic agents.
Katalin Prokai-Tatrai, Laszlo Prokai
doaj +1 more source
A non-synonymous coding change in the CYP19A1 gene Arg264Cys (rs700519) does not affect circulating estradiol, bone structure or fracture [PDF]
, 2011 Background The biosynthesis of estrogens from androgens is catalyzed by aromatase P450 enzyme, coded by the CYP19A1 gene on chromosome 15q21.2. Genetic variation within the CYP19A1 gene sequence has been shown to alter the function of the enzyme.
Wang, J.Z. +8 more
core +3 more sources
Issues arising when interpreting results from an in vitro assay for estrogenic activity [PDF]
, 2000 Concern about possible adverse effects caused by the inadvertent exposure of humans and wildlife to endocrine-active chemicals, has led some countries to develop an in vivo–in vitro screening program for endocrine effects.
Beresford, NA +3 more
core +1 more source
Statistical modeling suggests that antiandrogens in effluents from wastewater treatment works contribute to widespread sexual disruption in fish living in English rivers [PDF]
, 2009 Background: The widespread occurrence of feminized male fish downstream of some wastewater treatment works has led to substantial interest from ecologists and public health professionals.
Charles Tyler +10 more
core +4 more sources
Structural features of alkylphenolic chemicals associated with estrogenic activity [PDF]
, 1997 The ability of certain man-made chemicals to mimic the effects of natural steroid hormones and their potential to disrupt the delicate balance of the endocrine system in animals are of increasing concern.
Routledge, EJ, Sumpter, JP
core +1 more source