Therapeutic Advances in Chronic Disease, 2020 Anastrozole is a selective non-steroidal aromatase inhibitor that blocks the conversion of androgens to estrogens in peripheral tissues. It is used as adjuvant therapy for early-stage hormone-sensitive breast cancer in postmenopausal women.
Petr Potmešil, Radka Szotkowská
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Estrogenic activity, race/ethnicity, and Indigenous American ancestry among San Francisco Bay Area women. [PDF]
, 2019 Estrogens play a significant role in breast cancer development and are not only produced endogenously, but are also mimicked by estrogen-like compounds from environmental exposures.
Fejerman, Laura +6 more
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Mechanisms, Cofactors, and Augmenting Factors Involved in Anaphylaxis
Frontiers in Immunology, 2017 Anaphylaxis is an acute and life-threatening systemic reaction. Many triggers have been described, including food, drug, and hymenoptera allergens, which are the most frequently involved. The mechanisms described in anaphylactic reactions are complex and
Rosa Muñoz-Cano +12 more
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Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands [PDF]
ChemMedChem, 2017 AbstractThe importance of the heterocyclic core elements with peripheral phenolic and alkyl substituents as a dominant structural motif of ligands for the estrogen receptor (ER) has been well recognized. In this study we expanded the structural diversity of core elements by preparing selenium‐containing heterocycles and exploring the activities of ...
Silong, Zhang +10 more
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Bioaugmentation mitigates the impact of estrogen on coliform-grazing protozoa in slow sand filters [PDF]
, 2016 Exposure to endocrine-disrupting chemicals (EDCs), such as estrogens, is a growing issue for human and animal health as they have been shown to cause reproductive and developmental abnormalities in wildlife and plants and have been linked to male ...
Collins, Gavin +3 more
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Revista Brasileira de Ginecologia e Obstetrícia, 2006 OBJETIVOS: avaliar a eficácia do uso de isoflavonas da soja no tratamento de sintomas depressivos em mulheres com síndrome climatérica. MÉTODOS: estudo experimental placebo-controlado, randomizado e duplo-cego, com 84 pacientes climatéricas atendidas ...
Rilva Lopes de Sousa +4 more
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Current medical treatment of estrogen receptor-positive breast cancer [PDF]
, 2015 Approximately 80% of breast cancers (BC) are estrogen receptor (ER)-positive and thus endocrine therapy (ET) should be considered complementary to surgery in the majority of patients.
Basso, S. M. M. +2 more
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Inhibition of Human Phenol and Estrogen Sulfotransferase by Certain Non-Steroidal Anti-Inflammatory Agents [PDF]
Current Drug Metabolism, 2006 We hypothesized that aryl acetate- and aryl carboxylate-containing drugs would inhibit human phenol sulfotransferase (SULT1A1), and that selectivity would depend upon the interaction of the aryl portion of the molecule with the sulfotransferase acceptor binding site. This hypothesis was based on results with the rat orthologue showing that oxidation of
King, Roberta S., Ghosh, A., Wu, Jinfang
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Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer [PDF]
, 2016 PURPOSE: Inter-individual differences in estrogen concentrations during treatment with aromatase inhibitors (AIs) may contribute to therapeutic response and toxicity.
Desta, Zereunesay +11 more
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Aromatase Inhibitors as a Promising Direction for the Search for New Anticancer Drugs
MoleculesAromatase is an enzyme that plays a crucial role in the biosynthesis of estrogens, which are hormones that contribute to the growth of certain types of breast cancer.
Sara Janowska +3 more
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