Results 61 to 70 of about 138,106 (224)

Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor®) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study

Breast Cancer Research and Treatment, 2014
Phase I pharmacokinetic (PK) study assessed circulating estrogens in breast cancer (BC) patients on a non-steroidal aromatase inhibitor (NSAI) with vaginal atrophy using vaginal ultra-low-dose 0.03 mg estriol (E3) and Lactobacillus combination vaginal ...
G. Donders, P. Neven, M. Moegele, A. Lintermans, G. Bellen, V. Prasauskas, P. Grob, O. Ortmann, S. Buchholz   +8 more
semanticscholar   +1 more source

Prenatal betamethasone–postnatal N‐methyl‐D‐aspartic acid model of spasms: Update on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Infantile epilepsy spasms syndrome (IESS), formerly known as infantile spasms or West Syndrome, is a severe epilepsy syndrome affecting about 3 in 10,000 newborns in the United States. Characterized by clusters of epileptic spasms, interictal hypsarrhythmia, and developmental delays, IESS has diverse causes, including structural‐metabolic ...
Kayla Vieira, Antonia Schonwald, Chian‐Ru Chern, Kamya Shah, Jana Velíšková, Libor Velíšek   +5 more
wiley   +1 more source

Relationship of body mass index with aromatisation and plasma and tissue oestrogen levels in postmenopausal breast cancer patients treated with aromatase inhibitors [PDF]

, 2014
Background: Recent data have raised concern about the clinical efficacy of aromatase inhibitors in overweight and/or obese breast cancer patients. We report in vivo aromatase inhibition and plasma and tissue oestrogen levels in relation to body mass ...
Dowsett, Mitch, Haynes, Benjamin P., Lønning, Per Eystein   +2 more
core  

Antiestrogens: structure-activity relationships and use in breast cancer treatment

Journal of Molecular Endocrinology, 2016
About 70% of breast tumors express estrogen receptor alpha (ERα), which mediates the proliferative effects of estrogens on breast epithelial cells, and are candidates for treatment with antiestrogens, steroidal or non-steroidal molecules designed to ...
Tatiana Traboulsi, M. E. Ezzy, J. Gleason, S. Mader   +3 more
semanticscholar   +1 more source

Comparing Transcriptomic Responses to Chemicals Across Six Species Using the EcoToxChip RNASeq Database

Environmental Toxicology and Chemistry, EarlyView.
Abstract The EcoToxChip project includes RNA‐sequencing data from experiments involving model (Japanese quail, fathead minnow, African clawed frog) and ecological (double‐crested cormorant, rainbow trout, northern leopard frog) species at multiple life stages (whole embryo and adult) exposed to eight chemicals of environmental concern known to perturb ...
Krittika Mittal, Jessica Ewald, Doug Crump, Jessica Head, Markus Hecker, Natacha Hogan, Jianguo Xia, Niladri Basu   +7 more
wiley   +1 more source

QSAR with electrotopological state atom index. Part-3a. Receptor binding affinity of estrogens and non-steroidal estrogen analogs

, 2001
Department of Chemical Technology, University of Calcutta, Calcutta-700 009, India E-mail : achintya_saha@yahoo.com Division of Pharmaceutical Chemistry, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj-757 086, India E-mail : kunalroy_in@yahoo.com Department of Pharmaceutical Technology, Jadavpur University, Calcutta-700 032 ...
Achintya Saha, Kunal Roy, Kakali De, Sengupta, Chandana   +3 more
openaire   +1 more source

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel [PDF]

, 2019
Estrogen hormones play an important role in controlling glucose homeostasis and pancreatic β-cell function. Despite the significance of estrogen hormones for regulation of glucose metabolism, little is known about the roles of endogenous estrogen ...
Cabrera, Over, Cerne, Rok, Chen, Xingjuan, Efanov, Alexander M., Ficorilli, James V., Ma, Wenzhen, Obukhov, Alexander G., Syed, Samreen K.   +7 more
core   +1 more source

Fate and Removal of Pharmaceuticals and Illegal Drugs Present in Drinking Water and Wastewater

, 2017
Rapid development of pharmaceutical industry, and thus widespread availability of different types of therapeutical and increased intake of pharmaceuticals, results in elevated concentrations of pharmaceuticals in municipal wastewater subjected to ...
Anna Szymonik, J. Lach, K. Malińska
semanticscholar   +1 more source

Development of a Zebrafish Embryo‐Based Test System for Thyroid Hormone System Disruption: 3Rs in Ecotoxicological Research

Environmental Toxicology and Chemistry, EarlyView.
Abstract There is increasing concern regarding pollutants disrupting the vertebrate thyroid hormone (TH) system, which is crucial for development. Thus, identification of TH system–disrupting chemicals (THSDCs) is an important requirement in the Organisation for Economic Co‐operation and Development (OECD) testing framework.
Lisa Gölz, Melanie Blanc‐Legendre, Maximilian Rinderknecht, Laura Behnstedt, Sara Coordes, Luisa Reger, Sacha Sire, Xavier Cousin, Thomas Braunbeck, Lisa Baumann   +9 more
wiley   +1 more source

SAT-LB005 Association of Serum Estrogens and Estrogen Metabolites with Use of Non-Steroidal Anti-Inflammatory Drugs in Postmenopausal Women

Journal of the Endocrine Society, 2019
Background: In several recent studies of postmenopausal women, the use of non-steroidal anti-inflammatory drugs (NSAIDs) has been associated with lower circulating estrogens. These analgesics have also been studied in association with breast cancer risks with inconsistent findings.
Fuhrman, Barbara, Tiwari, Upasana, Majercak, Kayleigh, Ziegler, Regina   +3 more
openaire   +1 more source