The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety [PDF]
, 2015 Sang Jun Han +8 more
openalex +1 more source
Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6
Advanced Science, EarlyView.Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu +9 more
wiley +1 more source
Weak if any effect of estrogen on spatial memory in rats [PDF]
, 2002 In a number of species, males appear to have spatial abilities that are superior to those of females. The favored explanation for this cognitive difference is hormonal: higher testosterone levels in males than in females.
Farkas, Tamás +5 more
core
Advanced Science, EarlyView.This study developed a 3D endometrial assembloid model to study how uterine glands form and develop. They discovered key interactions between different cell types and identified WNT7B as a regulator controlled by estradiol‐mediated TGFβ1‐VDR interaction.
Xintong Li +12 more
wiley +1 more source
The prognostic value and relationships of patient characteristics, estrogen and progestin receptors, and site of relapse in primary breast cancer [PDF]
, 1988 J. Alexieva-Figusch +4 more
openalex +1 more source
G protein estrogen receptor as a potential therapeutic target in Raynaud’s phenomenon [PDF]
, 2022 Manal Fardoun +3 more
openalex +1 more source
Environmental Liquid Effluents, A Novel Approach For Treatment Of Industrial Waste Water [PDF]
, 2012 Nutrient enrichment or eutrophication of aquatic ecosystems can cause an increase in algae and aquatic plants, loss of component species, and loss of ecosystem function.
Antal, E. E
core
Rapid Microfluidic Drug Sensitivity Testing Within 5 Days Using Minimal Clinical Tumor Samples
Advanced Science, EarlyView.This study develops the air‐punched fabrication approach for nanoliter‐scale microcavity arrays with ultra‐smooth microcavity surfaces, with which rapid formation and 3D culture of tumor cell spheroids from small numbers of cell samples, as well as high‐throughput drug sensitivity testing can be achieved within 5 days.
Yi‐Xue Chen +11 more
wiley +1 more source
Aromatized Estrogens Amplify Nocturnal Growth Hormone Secretion in Testosterone-Replaced Older Hypogonadal Men [PDF]
, 2018 Ferdinand Roelfsema +5 more
openalex +1 more source
Advanced Science, EarlyView.We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim +6 more
wiley +1 more source