Results 311 to 320 of about 239,432 (343)
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Obstetrical & Gynecological Survey, 1962
The formation of estrogens and phenolic material from a large number of do Cis, C19 and C2i steroids and related structures has been investigated, employing a human placental microsomal preparation supplemented with TPNH and oxygen. The data from the incubation of 2 C 14-labeled androgens are included.
C, GUAL +4 more
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The formation of estrogens and phenolic material from a large number of do Cis, C19 and C2i steroids and related structures has been investigated, employing a human placental microsomal preparation supplemented with TPNH and oxygen. The data from the incubation of 2 C 14-labeled androgens are included.
C, GUAL +4 more
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2005
Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Estrogen sulfatase is a microsomal enzyme and is ubiquitously distributed in several mammalian tissues, among which the liver, placenta, and endocrine tissues exhibit relatively high activity. Because the major circulating precursors of estrogen are estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, estrogen sulfatase plays an important role not ...
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Estrogen Receptors and Anti-Estrogen Therapies
2006The realisation that breast cancer growth is regulated by the hormone estrogen led to the development of tamoxifen as the first target-directed cancer drug. Clearly, there is considerable headway to be made in further elucidating estrogen receptor function, in particular in identifying the mechanisms underlying endocrine resistance.
Lakjaya, Buluwela +3 more
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Estrogen and estrogen receptors in thyroid carcinomas
Journal of Surgical Oncology, 1991AbstractThyroid tissues, composed of normal thyroid (10 cases), Graves' thyroid (4), and papillary carcinoma (10), were measured for the presence of receptors for estrogen (ER) using an enzyme‐immunoassay method. The mean value of ER in papillary carcinoma tissues (4.0 ± 3.6 fmol/mg protein) was higher than that in normal thyroid tissues (0.8 ± 0.4 ...
Y, Mizukami +5 more
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Enzymatic treatment of estrogens and estrogen glucuronide
Journal of Environmental Sciences, 2009Natural and synthetic estrogens from sewage treatment systems are suspected to influence the reproductive health of the animals in the rivers. In this article, we investigated the enzymatic treatment of three estrogens (estrone, 17beta-estradiol, and 17alpha-ethynyletstradiol) by a fungal laccase which oxidize phenolic compounds with dissolved oxygen ...
Takaaki, Tanaka +6 more
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Estrogen, Anti‐Estrogen, and Gender
Annals of the New York Academy of Sciences, 2002Abstract:In Part 1 of this report, we review data on the effects of estrogen (E), the anti‐E tamoxifen (TMX), and testosterone (T) on methamphetamine (METH)‐induced neurotoxicity in female and male CD‐1 mice. Treatment of gonadectomized females with a physiological regimen of E significantly diminished the amount of striatal dopamine (DA) depletion to ...
Dean E, Dluzen, Janet L, McDermott
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International Journal of Gynecology & Obstetrics, 1990
The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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The main types of pharmacologic therapy used to treat the hormone deficiency of menopause are parenteral and oral administrations of estrogen. Parenteral administration results in predictable absorption without major intermediary metabolism, whereas all oral estrogens are subject to intestinal metabolism before entering the systemic circulation ...
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Estrogen and estrogen receptors of breast cancer
Journal of Surgical Oncology, 1975AbstractHuman breast cancer can be divided into a group that contains specific receptor sites for estrogen and a group without such specific estrogen‐binding sites. The presence of specific estrogen receptors in some tumors indicating hormonal dependency has been shown to be of predictive value for endocrine treatment.
V, Sahadevan +3 more
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Reviews in Endocrine and Metabolic Disorders, 2002
Gary E, Ackerman, Bruce R, Carr
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Gary E, Ackerman, Bruce R, Carr
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Estrogen 1,2-epoxides or estrogen quinones/semiquinones
Biochemical and Biophysical Research Communications, 1985Metabolic activation of estradiol leading to the formation of catechol estrogens is a prerequisite for its genotoxic activity. Both estrogen-o-quinones/semiquinones and estrogen 1,2-epoxides have been proposed to be responsible for this activity. Incubations of [3H]estradiol and [3H]1 alpha,2 alpha-epoxy-4-estrene-3-one-17 beta-ol (ketotautomer of ...
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