Results 41 to 50 of about 163,518 (339)

A mathematical model of Breast cancer (ER+) with excess estrogen: Mixed treatments using Ketogenic diet, endocrine therapy and Immunotherapy [PDF]

arXiv, 2022
Breast Cancer is a major public health problem and the most common diagnosed malignancy in woman. There have been significant developments in clinical approaches and theoretical experimental to understand the interactions of cancer cells dynamics with the immune system, also developments on analytical and computational models to help provide insights ...
arxiv  

A simple and robust method for connecting small-molecule drugs using gene-expression signatures [PDF]

BMC Bioinformatics 2008, 9:258, 2008
Interaction of a drug or chemical with a biological system can result in a gene-expression profile or signature characteristic of the event. Using a suitably robust algorithm these signatures can potentially be used to connect molecules with similar pharmacological or toxicological properties.
arxiv   +1 more source

Determination of steroid estrogens in wastewater by high performance liquid chromatography-tandem mass spectrometry [PDF]

, 2007
This paper discusses the requirement for, and presents an analytical procedure for, the determination of four unconjugated steroid hormones and a conjugated steroid (estrone-3-sulfate) in wastewaters.
A. Boobis, Belfroid, Benijts, Benijts, Bones, Bowers, Cargouet, Croley, Desbrow, D’Ascenzo, E. Cartmell, Gentili, Gomes, Gomes, Hu, Huang, Ingrand, Isobe, J.N. Lester, Johnson, Johnson, Komori, Kramer, Kuch, Lagana, Lagana, Lai, Larsson, Lee, Lee, Liang, Lopez de Alda, Lopez de Alda, M.D. Scrimshaw, Petrovic, Purdom, Quintana, Reddy, Rodgers-Gray, Rodriguez-Mozaz, Rodriguez-Mozaz, Routledge, Salvador, Shishida, Shore, Snyder, Snyder, T.Y. Chiu, Tabak, Tang, Ternes, Ternes, Vieno, Y.K.K. Koh   +53 more
core   +1 more source

FMO Study of the Interaction Energy between Human Estrogen Receptor $α$ and Selected Ligands [PDF]

arXiv, 2022
Fragment molecular orbital (FMO) calculations were performed in aqueous media which allowed us to obtain the interaction energy between the human estrogen receptor $\alpha$ ligand-binding domain (ER) and the selected ligands (L): 17$\beta$-estradiol (E2), 17$\alpha$-estradiol (17$\alpha$-E2), estriol (E3), genistein (GNT), diethylstilbestrol (DES ...
arxiv  

Statistical adjustment for a measure of healthy lifestyle doesn't yield the truth about hormone therapy [PDF]

IMS Collections 2008, Vol. 2, 142-152, 2008
The Women's Health Initiative randomized clinical trial of hormone therapy found no benefit of hormones in preventive cardiovascular disease, a finding in striking contrast with a large body of observational research. Understanding whether better methodology and/or statistical adjustment might have prevented the erroneous conclusions of observational ...
arxiv   +1 more source

Estrogen-Independent Activation of Estrogen Receptors [PDF]

Hypertension, 2011
See related article, pp 1161–1166 Sex differences showing a lower prevalence and better outcome after ischemic stroke in women have been described, differences that are abrogated by natural or surgical menopause.1,2 High levels of endogenous estrogens in premenopausal women have been associated with reduced risk for a number of diseases, such as ...
Matthias R. Meyer, Matthias Barton, Eric R. Prossnitz   +2 more
openaire   +3 more sources

Inhibition of Androgen-Independent Prostate Cancer by Estrogenic Compounds Is Associated with Increased Expression of Immune-Related Genes

Neoplasia: An International Journal for Oncology Research, 2006
The clinical utility of estrogens for treating prostate cancer (CaP) was established in the 1940s by Huggins. The classic model of the anti-CaP activity of estrogens postulates an indirect mechanism involving the suppression of androgen production ...
Ilsa M. Coleman, Jeffrey A. Kiefer, Lisha G. Brown, Tiffany E. Pitts, Peter S. Nelson, Kristen D. Brubaker, Robert L. Vessella, Eva Corey   +7 more
doaj   +1 more source

Oral contraceptives combined with interferon β in multiple sclerosis [PDF]

, 2015
Objective: To test the effect of oral contraceptives (OCs) in combination with interferon b (IFN-b) on disease activity in patients with relapsing-remitting multiple sclerosis (RRMS).
Barletta, Valeria T., De Angelis, Floriana, De Giglio, Laura, Gallo, Valentina, Marinelli, Fabiana, Marini, Stefano, Pagano, Veronica A., Pantano, Patrizia, Piattella, Maria C., Pozzilli, Carlo, Tomassini, Valentina   +10 more
core   +3 more sources

Molecular mechanism of estrogen–estrogen receptor signaling [PDF]

Reproductive Medicine and Biology, 2016
Abstract17β‐Estradiol (E2), as the main circulating estrogen hormone, regulates many tissue and organ functions in physiology. The effects of E2 on cells are mediated by the transcription factors and estrogen receptor (ER)α and ERβ that are encoded by distinct genes.
Yasar, Pelin, Ayaz, Gamze, User, Sirma Damla, Gupur, Gizem, Muyan, Mesut   +4 more
openaire   +4 more sources

Select estrogens within the complex formulation of conjugated equine estrogens (Premarin^®) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease

BMC Neuroscience, 2006
Background Results of the Women's Health Initiative Memory Study (WHIMS) raised concerns regarding the timing and formulation of hormone interventions.
Brinton Roberta, Zhao Liqin
doaj   +1 more source