Results 81 to 90 of about 163,518 (339)
Defective spermatogenesis: Martin et al. respond [PDF]
, 2008 This is an Open Access article - Copyright @ National Institute of Environmental Health Science.BACKGROUND: Male reproductive tract abnormalities such as hypospadias and cryptorchidism, and testicular cancer have been proposed to comprise a common ...
Boobis, Alan R. +5 more
core +2 more sources
Ubiquitination of transcription factors in cancer: unveiling therapeutic potential
Molecular Oncology, EarlyView.In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley +1 more source
Frontiers in Endocrinology, 2023 BackgroundAbnormally changed steroid hormones during pregnancy are closely related to the pathological process of gestational diabetes mellitus (GDM). Our aim was to systematically profile the metabolic alteration of circulating steroid hormones in GDM ...
Na Yang +10 more
doaj +1 more source
Removal of ecotoxicity of 17α-ethinylestradiol using TAML/peroxide water treatment [PDF]
, 2015 17α -ethinylestradiol (EE2), a synthetic oestrogen in oral contraceptives, is one of many pharmaceuticals found in inland waterways worldwide as a result of human consumption and excretion into wastewater treatment systems. At low parts per trillion (ppt)
A Chanda +27 more
core +1 more source
Bayesian Variable Selection for Probit Mixed Models Applied to Gene Selection [PDF]
Bayesian Analysis 6, 2 (2011) 209-230, 2011 In computational biology, gene expression datasets are characterized by very few individual samples compared to a large number of measurements per sample. Thus, it is appealing to merge these datasets in order to increase the number of observations and diversify the data, allowing a more reliable selection of genes relevant to the biological problem ...
arxiv +1 more source
FEBS Open Bio, EarlyView.We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang +9 more
wiley +1 more source
Metabolomic profiling unravels DNA adducts in human breast that are formed from peroxidase mediated activation of estrogens to quinone methides. [PDF]
PLoS ONE, 2013 Currently there are three major hypotheses that have been proposed for estrogen induced carcinogenicity, however exact etiology remains unknown. Based on the chemical logic, studies were undertaken to investigate if estrogens could generate quinone ...
Nilesh W Gaikwad
doaj +1 more source
Efficient algorithms for building representative matched pairs with enhanced generalizability [PDF]
arXiv, 2022 Many recent efforts center on assessing the ability of real-world evidence (RWE) generated from non-randomized, observational data to produce results compatible with those from randomized controlled trials (RCTs). One noticeable endeavor is the RCT DUPLICATE initiative (Franklin et al., 2020, 2021).
arxiv
Estrogens regulate the hepatic effects of Growth Hormone, a hormonal interplay with multiple fates
Frontiers in Endocrinology, 2013 The liver responds to estrogens and GH which are critical regulators of body growth, gender-related hepatic functions, and intermediate metabolism. The effects of estrogens on liver can be direct, through the direct actions of hepatic ER, or indirect ...
Leandro eFernandez-Perez +3 more
doaj +1 more source
Microbial community assembly, theory and rare functions [PDF]
, 2013 Views of community assembly have traditionally been based on the contrasting perspectives of the deterministic niche paradigm and stochastic neutral models. This study sought to determine if we could use empirical interventions conceived from a niche and
Baptista, J.D.C. +4 more
core +2 more sources