Results 201 to 210 of about 88,646 (317)

Behavioral Alterations in Mice Exposed to Manganese via Drinking Water: Effects of Sex and a Lipopolysaccharide Challenge

open access: yesJournal of Applied Toxicology, Volume 45, Issue 4, Page 669-684, April 2025.
ABSTRACT Manganese (Mn) is an essential and important metal; however, overexposures lead to adverse neurological outcomes. Nonoccupational Mn overexposure occurs primarily through consumption of Mn‐contaminated drinking water (DW). Sex differences in terms of nervous and immune systems' responsiveness to excessive Mn in the DW are understudied.
Helaina D. Ludwig   +2 more
wiley   +1 more source

SLO2.1/NALCN Functional Complex Activity in Mouse Myometrial Smooth Muscle Cells During Pregnancy

open access: yesJournal of Cellular Physiology, Volume 240, Issue 4, April 2025.
ABSTRACT At the end of pregnancy, the uterus transitions from a quiescent to a highly contractile state. This is partly due to the depolarization of the resting membrane potential in uterine (myometrial) smooth muscle cells (MSMCs). In human MSMCs, the membrane potential is regulated by a functional complex between the sodium (Na+)‐activated potassium (
Juan J. Ferreira   +11 more
wiley   +1 more source

Development of an LC–MS/MS Method for Quantifying Occidiofungin in Rabbit Plasma

open access: yesJournal of Mass Spectrometry, Volume 60, Issue 4, April 2025.
ABSTRACT Fungal infections are caused by opportunistic pathogens that can be life threatening and have been growing in prevalence. Many clinically relevant pathogens have resistance to or are developing resistance to the commonly used antifungal treatments.
Andrew Cothrell   +2 more
wiley   +1 more source

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
In females, estradiol deficiency is a major environmental factor contributing to the age‐associated effects on satellite cells. To assess cell‐intrinsic versus environmental regulation of satellite cells, we perform two transplantation experiments, Adult or Aged satellite cells transplanted into Adult recipients, and Adult satellite cells transplanted ...
Brian P. Sullivan   +7 more
wiley   +1 more source

Role of Seed Therapy on Estrous and Non-Estrous Cycle in Healthy Female Rats. [PDF]

open access: yesFood Sci Nutr
Majeed I   +6 more
europepmc   +1 more source

DNMT3a Deficiency Contributes to Anesthesia/Surgery‐Induced Synaptic Dysfunction and Cognitive Impairment in Aged Mice

open access: yesAging Cell, Volume 24, Issue 4, April 2025.
DNMT3a downregulation appears to causally contribute to surgery‐induced cognitive impairment, whereas its overexpression effectively alleviated cognitive impairment behaviors. Mechanistically, DNMT3a downregulation induced by anesthesia/surgery could disrupt DNA methylation stability in the hippocampus of aged mice. This decreased the binding of DNMT3a
Peilin Cong   +10 more
wiley   +1 more source

The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors. [PDF]

open access: yesJ Pharmacol Exp Ther
Costa PC   +5 more
europepmc   +1 more source

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