Results 221 to 230 of about 57,832 (298)

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

open access: yesExperimental Physiology, Volume 111, Issue 4, Page 1781-1795, 1 April 2026.
Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques   +6 more
wiley   +1 more source

Models of the human heart for biomedical research: Opportunities and challenges

open access: yesPhysiological Reports, Volume 14, Issue 7, April 2026.
This manuscript reviews models that can be used to study the physiology and pathophysiology of the heart, and describes some the limitaions and ethical concerns associated with the use of human tissue. Abstract Model systems that mimic human cardiac structure and function are essential for the development of novel diagnostics and effective treatments ...
Katrin Streckfuss‐Bömeke   +21 more
wiley   +1 more source

A novel method for estrous cycle staging using supervised object detection. [PDF]

open access: yesNPP Digit Psychiatry Neurosci
Babaev B   +4 more
europepmc   +1 more source

Sex‐dependent effects of environmental enrichment on mood‐related behaviors, central and peripheral BDNF, and adrenal catecholamine enzymes in mice

open access: yesPhysiological Reports, Volume 14, Issue 7, April 2026.
Abstract Housing conditions, particularly environmental enrichment (EE), can influence experimental outcomes and welfare. While EE is generally regarded as beneficial, a male bias exists in research supporting this. This study investigated whether sex differences exist in levels of BDNF in the brain and peripheral tissues in environmentally enriched ...
M. F. Herselman   +4 more
wiley   +1 more source

Diminazene Aceturate Ameliorates Hypertension‐Induced Cognitive Impairment by Disrupting the CCN1–Integrin αvβ6–TGF‐β Axis and Preserving Mitochondrial Integrity

open access: yesThe FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Hypertension drives cognitive decline through a previously unrecognized CCN1–integrin αvβ6–TGF‐β signaling axis that culminates in mitochondrial dysfunction and hippocampal neuronal injury. In this pathway, angiotensin II induces CCN1 upregulation, which activates αvβ6 integrin‐mediated release of latent TGF‐β, triggering SMAD2/3 phosphorylation and ...
Xufang Huo   +10 more
wiley   +1 more source

The Influence of the Estrous Cycle on Neuropeptide S Receptor-Mediated Behaviors. [PDF]

open access: yesJ Pharmacol Exp Ther
Costa PC   +5 more
europepmc   +1 more source

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