Results 61 to 70 of about 56,034 (249)

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Signaling in The Prefrontal Cortex Modulates Cued Fear Learning, But Not Spatial Working Memory, in Female Rats [PDF]

, 2018
A genetic polymorphism within the gene encoding the pituitary adenylate cyclase- activating polypeptide (PACAP) receptor type I (PAC1R) has recently been associated with hyper-reactivity to threat-related cues in women, but not men, with post-traumatic ...
Gilmartin, Marieke R., Herbst, Matthew R., Kirry, Adam J., Maskeri, Michelle M., Poirier, Sarah E., Rothwell, Amy C., Twining, Robert C.   +6 more
core   +1 more source

Comparison of the Effects of Early Pregnancy with Human Interferon, Alpha 2 (IFNA2), on Gene Expression in Bovine Endometrium [PDF]

, 2012
Interferon tau (IFNT), a type I IFN similar to alpha IFNs (IFNA), is the pregnancy recognition signal produced by the ruminant conceptus. To elucidate specific effects of bovine IFNT and of other conceptus-derived factors, endometrial gene expression ...
Bauersachs, Stefan, Büttner, Mathias, Meyer, Heinrich H. D., Minten, Megan, Reichenbach, Horst-Dieter, Reichenbach, Myriam, Sax, Gerhard, Spencer, Thomas E., Ulbrich, Susanne E., Winter, Gerhard, Wolf, Eckhard   +10 more
core   +1 more source

Testicular SIRT1 Loss Reveals an Aging‐Like Proteomic Landscape and Precipitates Reproductive Deterioration

Andrology, EarlyView.
ABSTRACT Background Advanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD+‐dependent deacetylase, plays a pivotal role in maintaining oxidative balance and cellular homeostasis.
María Iniesta‐Cuerda, Jiřina Havránková, Hedvika Řimnáčová, Jiří Moravec, František Liška, Martin Knytl, Milena Králíčková, Jan Nevoral   +7 more
wiley   +1 more source

Improved timed-mating, non-invasive method using fewer unproven female rats with pregnancy validation via early body mass increases [PDF]

, 2018
For studies requiring accurate conception-timing, reliable, efficient methods of detecting oestrus reduce time and costs, whilst improving welfare. Standard methods use vaginal cytology to stage cycle, and breeders are paired–up using approximately five ...
Agata K Stramek, Barnett SW, Becker JB, Crean GP, Cripps AW, Feder HH, Ferguson SA, Goldman JM, Gualillo O, Johnson ML, Johnson ML, Lopez-Luna P, Marcondes FK, Michelle L Johnson, Prager EM, Pujol E, Trujillo ML, Turner KM, Victoria J Taylor   +18 more
core   +1 more source

Hormonal Treatment During Ex Vivo Lung Perfusion Ameliorates Brain Death Induced Inflammation

Artificial Organs, EarlyView.
Treatment of lungs during ex vivo perfusion with 17β‐estradiol and methylprednisolone improved graft quality. In females, treated and non‐treated groups presented reduced leukocyte infiltration and only the treatment improved perfusion flow. In males, treatment improved lung function by increasing compliance, paO2, and perfusion flow.
Marina Vidal‐dos‐Santos, Roberto Armstrong‐Jr, Fernanda Yamamoto Ricardo‐da‐Silva, Lucas Ferreira da Anunciação, Mayara Munhoz de Assis Ramos, Cristiano Jesus de Correia, Petra J. Ottens, Luiz Felipe Pinho Moreira, Henri G. D. Leuvenink, Ana Cristina Breithaupt‐Faloppa   +9 more
wiley   +1 more source

Estrous cycle manipulation in dogs

Clinical Theriogenology
Domestic dogs provide a unique challenge to the veterinary practitioner to manipulate estrous cycle. Due to an obligatory 120-day anestrus, dogs cycle much less frequently than other domestic species. This can pose a problem for owners and breeders wishing to produce pups at a certain part of the year or temporarily prevent pregnancy due to competition,
Gail McRae, Erin Runcan, Aime Johnson
openaire   +1 more source

Mouse Estrous Cycle Identification Tool and Images

PLoS ONE, 2012
The efficiency of producing timed pregnant or pseudopregnant mice can be increased by identifying those in proestrus or estrus. Visual observation of the vagina is the quickest method, requires no special equipment, and is best used when only proestrus or estrus stages need to be identified.
Byers, Shannon L, Wiles, Michael V, Dunn, Sadie L, Taft, Robert A   +3 more
openaire   +5 more sources

Cytochrome P450 1A1 influences obesity‐induced pulmonary hypertension

British Journal of Pharmacology, EarlyView.
Background and Purpose The contribution of obesity to pulmonary arterial hypertension (PAH) pathophysiology remains poorly understood. Adipose tissue synthesises estrogens via cytochrome P450 (CYP) 19A1 (aromatase), whereas circulating estrogens are metabolised in the lung by CYP1A1.
Joshua P. Dignam, Smriti Sharma, Gregor Aitchison, Ayman Gebril, Ioannis Stasinopoulos, Sofia Laforest, Chelbi Coyle, Ruth Andrew, Natalie Z. M. Homer, Sébastien Bonnet, Sandra Breuils‐Bonnet, Martin Wabitsch, Margaret R. MacLean   +12 more
wiley   +1 more source

Reinforcement learning across the rat estrous cycle

Psychoneuroendocrinology, 2019
Reinforcement learning, the process by which an organism flexibly adapts behavior in response to reward and punishment, is vital for the proper execution of everyday behaviors, and its dysfunction has been implicated in a wide variety of mental disorders.
Jeroen P.H. Verharen, Jiska Kentrop, Louk J.M.J. Vanderschuren, Roger A.H. Adan   +3 more
openaire   +5 more sources

Synergistic RU486 and olaparib therapy enhances apoptosis in endometriosis by simultaneously targeting hormonal signalling and DNA repair

British Journal of Pharmacology, EarlyView.
Background and Purpose Endometriosis is a chronic, hormone‐dependent disorder characterized by ectopic implantation of endometrial tissue, often accompanied by pain and infertility. Although the progesterone receptor modulator RU486 is effective for pain relief, its impact on lesion regression is limited, possibly due to apoptosis resistance and ...
Yujie Peng, Meng Zhang, Libo Zhu, Wenqiang Qian, Jingjing Yan, Huidi Jiang, Yu Xin, Ying Zhang, Dongli Sun, Weidong Fei, Mengdan Zhao   +10 more
wiley   +1 more source