Results 61 to 70 of about 481,477 (305)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Effect of Sn Loading on the Characteristics of Pt Electrocatalysts Supported on Reduced Graphene Oxide for Application as Direct Ethanol Fuel Cell Anode

International Journal of Electrochemical Science, 2017
The effect of Sn loading (5–30 mol %) on Pt catalysts supported on reduced graphene oxide was investigated for ethanol electro-oxidation in acidic medium.
Guilherme L. Cordeiro, Valter Ussui, Nildemar A. Messias, Ricardo M. Piasentin, Nelson B. de Lima, Almir O. Neto, Dolores R.R. Lazar   +6 more
doaj   +1 more source

Potential antioxidant activity of pomegranate peel and seed extracts and synergism with added phenolic antioxidants in a liposome system: a preliminary study [PDF]

, 2014
peer-reviewedThis study describes the use of liposomes as biological membrane models to evaluate the potential of natural antioxidants as inhibitors of lipid peroxidation.
Altunkaya, A.
core  

Applicability of biobased packaging materials for long shelf-life food products [PDF]

, 2016
The research aim was to evaluate the applicability of biobased plastics for packing long shelf-life food products, both on laboratory and industrial scale.
De Meulenaer, Bruno, Devlieghere, Frank, Peelman, Nanou, Ragaert, Peter, Verguldt, Elien   +4 more
core   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Facile and innovation synthesis of Zn-Mn-Co-LDH/polypyrrole and its application in investigating ethanol oxidation in an alkaline medium

Electrochemistry Communications
Overvoltage and low current are observed for ethanol electrooxidation on the surface of many unmodified electrodes. Therefore, it is desirable to use a suitable catalyst for ethanol electrooxidation to increase the current. This research introduces a new
Elhameh Saeb, Karim Asadpour-Zeynali, Hossein Dastangoo   +2 more
doaj   +1 more source

Liquid-Phase Ethanol Oxidation and Gas-Phase CO Oxidation Reactions over M Doped (M = Ag, Au, Pd, and Ni) and MM′ Codoped CeO2 Nanoparticles

Journal of Chemistry, 2016
Transition metal doped metal oxides have been studied extensively for potential applications to environments and chemical industry. Herein, M doped (M = Ag, Au, Pd, and Ni) and MM′ codoped CeO2 nanoparticles (NPs) were prepared by a hydrothermal method ...
Yohan Park, Yulri Na, Debabrata Pradhan, Youngku Sohn   +3 more
doaj   +1 more source

Degradation of acetaldehyde and its precursors by Pelobacter carbinolicus and P. acetylenicus. [PDF]

PLoS ONE, 2014
Pelobacter carbinolicus and P. acetylenicus oxidize ethanol in syntrophic cooperation with methanogens. Cocultures with Methanospirillum hungatei served as model systems for the elucidation of syntrophic ethanol oxidation previously done with the lost ...
Alexander Schmidt, Marco Frensch, David Schleheck, Bernhard Schink, Nicolai Müller   +4 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source