Results 131 to 140 of about 6,050 (250)

A Novel Multimodal LC–MS/MS Panel for the Comprehensive Diagnosis of Neurometabolic Disorders in CSF

Journal of Inherited Metabolic Disease, Volume 49, Issue 3, May 2026.
ABSTRACT Metabolic testing of cerebrospinal fluid (CSF) is essential for early diagnosis of neurometabolic disorders. However, the large number of differential diagnoses, the phenotypic variance within a clinical picture, and the disease rarity complicate targeted metabolic diagnostics.
Stine Christ, Julia Rossmann, Sylvia Richter, Sven Garbade, Glynis Klinke, Nenad Blau, Georg Friedrich Hoffmann, Jürgen Günther Okun, Thomas Opladen   +8 more
wiley   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Gene Expression Patterns Regulating Peanut Reproductive Phenology

Plant Direct, Volume 10, Issue 5, May 2026.
ABSTRACT Peanut reproduction is foundational for crop yield, breeding, and evolution. However, gene regulation underlying peanut flowering pattern and timing has received limited attention. Cultivated peanut (Arachis hypogaea L.) shows two distinct flowering patterns between two subspecies, with ssp.
Carlos Henrique Cardon, Adnan Kivanc Corut, Ye Chu, Jason Wallace, Ran Hovav, Peggy Ozias‐Akins   +5 more
wiley   +1 more source

Ann Work Expo Health [PDF]

Cleaning and disinfecting products consisting of a mixture of hydrogen peroxide (HP), peracetic acid (PAA), and acetic acid (AA) are widely used as sporicidal agents in health care, childcare, agricultural, food service, and food production industries ...

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T3SS effector and regulator discovery by predicting interacting partners of T3SS chaperones in Pseudomonas aeruginosa

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Pseudomonas aeruginosa is a prominent opportunistic pathogen whose virulence is closely linked to its Type III Secretion System (T3SS), a specialized apparatus that injects effector proteins into host cells. T3SS chaperones are essential for stabilizing, delivering, and regulating T3SS expression.
Jing Zhang
wiley   +1 more source

Advances in Wine Yeast Autolysis: Biochemical and Molecular Mechanisms, and the Release of Organic Compounds in White and Sparkling Wines—An Updated Review

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT Wine yeasts play a central role in alcoholic fermentation and significantly contribute to the sensory attributes of wines through cellular autolysis during lees aging (sur lie), especially in white wines. This process releases organic compounds that alter the wine's chemical and sensory profile.
José Ricardo Machado dos Santos, Aniela Pinto Kempka   +1 more
wiley   +1 more source

Phospholipid Profiling Established by Structure‐Rich Fragments for Molecular Species Level Shotgun Analysis

Rapid Communications in Mass Spectrometry, Volume 40, Issue 8, 30 April 2026.
ABSTRACT Rationale Accurate identification of phospholipid molecular species remains a major challenge in shotgun lipidomics because conventional tandem mass spectrometry typically resolves only one structural moiety at a time. This structural ambiguity limits confident lipid biomarker discovery and biological interpretation.
Rong Chen, Amber H. Jannasch, Bruce R. Cooper, Jonathan H. Shannahan, Christina R. Ferreira   +4 more
wiley   +1 more source

Fair and Square: Design, Synthesis and Biological Evaluations of Squaric Acid Derivatives as Novel HDAC8 Inhibitors

ChemMedChem, Volume 21, Issue 8, 28 April 2026.
Histone deacetylase 8 (HDAC8) is a clinically validated target in neuroblastoma, where isoform selective inhibition offers a strategy to suppress tumour growth while limiting off‐target toxicity. Hydroxamic acids remain the dominant zinc‐binding group (ZBG) in HDAC inhibitors but are also associated with metabolic instability, suboptimal ...
Nathan Long, Franz‐Josef Meyer‐Almes, Aleksandra Kopranovic, Stephen P. Wren   +3 more
wiley   +1 more source

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

European Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot, Iván Lavandera, Vicente Gotor‐Fernández   +2 more
wiley   +1 more source

Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer’s Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Maternal choline supplementation (MCS) is utilized in the Ts65Dn mouse model of Down syndrome (DS) and Alzheimer's disease (AD). At ~6 months of age, laser capture microdissection and single population RNA‐sequencing of three hippocampal neuron populations (CA1 and CA3 pyramidal neurons and dentate gyrus granule cells) were conducted.
Melissa J. Alldred, Kyrillos W. Ibrahim, Harshitha Pidikiti, Sang Han Lee, Adriana Heguy, Gabriela Chiosis, Elliott J. Mufson, Grace E. Stutzmann, Stephen D. Ginsberg   +8 more
wiley   +1 more source