Synthesis of Trifluoromethylated Monoterpene Amino Alcohols [PDF]
Molecules, 2022 For the first time, monoterpene trifluoromethylated β-hydroxy-benzyl-O-oximes were synthesized in 81–95% yields by nucleophilic addition of the Ruppert–Prakash reagent (TMSCF3) to the corresponding β-keto-benzyl-O-oximes based on (+)-nopinone ...
Polina A. Petrova +5 more
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Amino Alcohols as Potential Antibiotic and Antifungal Leads [PDF]
Molecules, 2022 Five focused compound libraries (forty-nine compounds), based on prior studies in our laboratory were synthesized and screened for antibiotic and anti-fungal activity against S. aureus, E. coli, K. pneumoniae, P. aeruginosa, A. baumannii, C. albicans and
Jennifer R. Baker +7 more
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New Nitrogen, Sulfur-, and Selenium-Donating Ligands Derived from Chiral Pyridine Amino Alcohols. Synthesis and Catalytic Activity in Asymmetric Allylic Alkylation [PDF]
Molecules, 2021 Although many chiral ligands for asymmetric catalysis have been developed, there is still a need for new structures allowing the modular approach. Recently, easy synthesis of chiral pyridine-containing β-amino alcohols has been elaborated by opening ...
Marzena Wosińska-Hrydczuk +1 more
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Biosynthesis of Chiral Amino Alcohols via an Engineered Amine Dehydrogenase in E. coli [PDF]
Frontiers in Bioengineering and Biotechnology, 2022 Chiral amino alcohols are prevalent synthons in pharmaceuticals and synthetic bioactive compounds. The efficient synthesis of chiral amino alcohols using ammonia as the sole amino donor under mild conditions is highly desired and challenging in organic ...
Feifei Tong +13 more
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Amino Alcohols from Eugenol as Potential Semisynthetic Insecticides: Chemical, Biological, and Computational Insights [PDF]
Molecules, 2021 A series of β-amino alcohols were prepared by the reaction of eugenol epoxide with aliphatic and aromatic amine nucleophiles. The synthesized compounds were fully characterized and evaluated as potential insecticides through the assessment of their ...
Renato B. Pereira +9 more
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Multicomponent Domino Cyclization of Ethyl Trifluoropyruvate with Methyl Ketones and Amino Alcohols as A New Way to γ-Lactam Annulated Oxazacycles [PDF]
Molecules, 2023 A new route to bicyclic γ-lactams was found, which was proposed as a three-component cyclization of ethyl trifluoropyruvate with methyl ketones and 1,2-, 1,3-amino alcohols.
Marina V. Goryaeva +7 more
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Glycogen Phosphorylase: A Drug Target of Amino Alcohols in Echinococcus granulosus, Predicted by a Computer-Aided Method [PDF]
Frontiers in Microbiology, 2020 Echinococcosis is an important parasitic disease that threats human health and animal husbandry worldwide. However, the low cure rate of clinical drugs for this disease is a challenge. Hence, novel compounds and specific drug targets are urgently needed.
Congshan Liu +4 more
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Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids [PDF]
Angewandte Chemie - International Edition, 2021 Timothy J. Donohoe, William R F Goundry
exaly +2 more sources
In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols [PDF]
Royal Society Open Science, 2018 The flow coupling of epichlorohydrin with substituted phenols, while efficient, limits the nature of the epoxide available for the development of focused libraries of β-amino alcohols.
Peter J. Cossar +3 more
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Synthesis of Amino-Acid-Based Nitroalkenes
Organics, 2022 Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes have been scarcely explored so far, although they may exhibit interesting biological ...
Velisaria-Eleni Gerogianni +3 more
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