Glycogen Phosphorylase: A Drug Target of Amino Alcohols in Echinococcus granulosus, Predicted by a Computer-Aided Method [PDF]
Frontiers in Microbiology, 2020 Echinococcosis is an important parasitic disease that threats human health and animal husbandry worldwide. However, the low cure rate of clinical drugs for this disease is a challenge. Hence, novel compounds and specific drug targets are urgently needed.
Congshan Liu +4 more
doaj +2 more sources
Microwave-Assisted Kabachnik–Fields Reaction with Amino Alcohols as the Amine Component [PDF]
Molecules, 2019 In this paper, the microwave (MW)-assisted catalyst-free and mostly solvent-free Kabachnik−Fields reaction of amino alcohols, paraformaldehyde, and various >P(O)H reagents (dialkyl phosphites, ethyl phenyl-H-phosphinate, and secondary phosphine ...
Ádám Tajti +4 more
doaj +2 more sources
Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids. [PDF]
Angew Chem Int Ed Engl, 2021 Hall CJJ, Goundry WRF, Donohoe TJ.
europepmc +2 more sources
Oxidative Lactamization of Amino Alcohols: An Overview [PDF]
Journal of Chemistry Letters, 2020 Lactams are essential functional groups in a number of pharmacologically and biologically active compounds. They are widely found in many natural products, marketed drugs, as well as in the base of polymeric structures (e.g., polyamides/Nylons).
Lakashima Sreerama +2 more
doaj +1 more source
In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols [PDF]
Royal Society Open Science, 2018 The flow coupling of epichlorohydrin with substituted phenols, while efficient, limits the nature of the epoxide available for the development of focused libraries of β-amino alcohols.
Peter J. Cossar +3 more
doaj +1 more source
Synthesis of Amino-Acid-Based Nitroalkenes
Organics, 2022 Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes have been scarcely explored so far, although they may exhibit interesting biological ...
Velisaria-Eleni Gerogianni +3 more
doaj +1 more source
Photoinduced β-fragmentation of aliphatic alcohol derivatives for forging C–C bonds
Nature Communications, 2022 Transformations of alcohols, which are ubiquitous in chemistry and are native functionalities in many natural products and bioactive molecules, are cornerstones of organic synthesis.
Yiman Gao +6 more
doaj +1 more source
Diastereoselective synthesis of vicinal amino alcohols [PDF]
Organic & Biomolecular Chemistry, 2012 The vicinal amino alcohol is a common motif in natural products and pharmaceuticals. Amino acids constitute a natural, inexpensive, and enantiopure choice of starting material for the synthesis of such functionalities. However, the matters concerning diastereoselectivity are not obvious.
Koskinen, Ari, Karjalainen, Oskari
openaire +5 more sources
Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives
Chemistry Proceedings, 2021 Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β-amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results
Cláudia Teixeira +7 more
doaj +1 more source
Sugar Alcohols Have a Key Role in Pathogenesis of Chronic Liver Disease and Hepatocellular Carcinoma in Whole Blood and Liver Tissues. [PDF]
, 2020 The major risk factors for hepatocellular carcinoma (HCC) are hepatitis C and B viral infections that proceed to Chronic Liver Disease (CLD). Yet, the early diagnosis and treatment of HCC are challenging because the pathogenesis of HCC is not fully ...
El-Said, Hala +5 more
core +2 more sources