Hydrogen‐Borrowing Alkylation of 1,2‐Amino Alcohols in the Synthesis of Enantioenriched γ‐Aminobutyric Acids [PDF]
Angewandte Chemie - International Edition, 2021 Timothy Donohoe, William Goundry
exaly +2 more sources
In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols [PDF]
Royal Society Open Science, 2018 The flow coupling of epichlorohydrin with substituted phenols, while efficient, limits the nature of the epoxide available for the development of focused libraries of β-amino alcohols.
Peter J. Cossar +3 more
doaj +1 more source
Synthesis of Amino-Acid-Based Nitroalkenes
Organics, 2022 Fatty-acid-based nitroalkenes have recently received great attention because of their bioactivities. On the contrary, peptide- or amino-acid-based nitroalkenes have been scarcely explored so far, although they may exhibit interesting biological ...
Velisaria-Eleni Gerogianni +3 more
doaj +1 more source
Oxidative Lactamization of Amino Alcohols: An Overview [PDF]
Journal of Chemistry Letters, 2020 Lactams are essential functional groups in a number of pharmacologically and biologically active compounds. They are widely found in many natural products, marketed drugs, as well as in the base of polymeric structures (e.g., polyamides/Nylons).
Lakashima Sreerama +2 more
doaj +1 more source
Photoinduced β-fragmentation of aliphatic alcohol derivatives for forging C–C bonds
Nature Communications, 2022 Transformations of alcohols, which are ubiquitous in chemistry and are native functionalities in many natural products and bioactive molecules, are cornerstones of organic synthesis.
Yiman Gao +6 more
doaj +1 more source
Diastereoselective synthesis of vicinal amino alcohols [PDF]
Organic & Biomolecular Chemistry, 2012 The vicinal amino alcohol is a common motif in natural products and pharmaceuticals. Amino acids constitute a natural, inexpensive, and enantiopure choice of starting material for the synthesis of such functionalities. However, the matters concerning diastereoselectivity are not obvious.
Koskinen, Ari, Karjalainen, Oskari
openaire +5 more sources
Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives
Chemistry Proceedings, 2021 Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β-amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results
Cláudia Teixeira +7 more
doaj +1 more source
Hydrogen Bonding and Polymorphism of Amino Alcohol Salts with Quinaldinate: Structural Study
Molecules, 2022 Three amino alcohols, 3-amino-1-propanol (abbreviated as 3a1pOH), 2-amino-1-butanol (2a1bOH), and 2-amino-2-methyl-1-propanol (2a2m1pOH), were reacted with quinoline-2-carboxylic acid, known as quinaldinic acid.
Nina Podjed, Barbara Modec
doaj +1 more source
Synthesis of Azetidine-Based Beta-Amino Alcohols
Medical Sciences Forum, 2022 Beta-amino alcohols are versatile chemicals used as scaffolds in medicinal chemistry and they are key factors for the efficacy of numerous pharmaceutical products.
Linda Supe
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Synthesis of 2H-pyrroles via iron catalyzed dehydrogenative coupling and C–C bond cleavage
Green Synthesis and Catalysis, 2021 Iron catalyzed coupling of β-amino alcohols with allylic alcohols for the synthesis of 3,4-dihydro-2H-pyrrole derivatives has been developed. Mechanistic studies suggest that the reaction involves iron catalyzed dehydrogenative coupling and C–C bond ...
Suya Cui +7 more
doaj +1 more source