Results 171 to 180 of about 4,347 (272)

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

open access: yesAdvanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo   +6 more
wiley   +1 more source

Synergistic Interface Engineering via Buffer Layer and UVO Treatment for High‐Performance PbS Quantum Dot Near‐Infrared Photodiodes

open access: yesAdvanced Science, Volume 13, Issue 52, 18 September 2026.
A dual‐interface strategy combining a solvent‐orthogonal Poly‐TPD buffer with UV–ozone tuning of PbS‐EDT reconstructs interfacial energetics and defect chemistry in PbS CQD photodiodes. The optimized interface suppresses shunt‐ and trap‐related leakage, reduces noise, and enables high‐detectivity near‐infrared detection with imaging capability ...
Chuan Wei   +8 more
wiley   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

open access: yesAdvanced Science, Volume 13, Issue 53, 24 September 2026.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen   +11 more
wiley   +1 more source

Changes in levels of endocannabinoidome mediators in mice with cancer cachexia: links with steatosis and gut microbial dysbiosis. [PDF]

open access: yesBJC Rep
Degraeve AL   +8 more
europepmc   +1 more source

α‐Synuclein Aggregate‐Disassembling Compounds Prolong Survival in a Mouse Model of Parkinson's Disease

open access: yesAggregate, Volume 7, Issue 9, September 2026.
All‐D peptides that bind monomeric α‐synuclein shift the aggregation equilibrium, dismantle pathogenic fibrils, and suppress seeding activity in vitro and in cells. In a Parkinson's disease mouse model, treatment delays disease progression and extends survival, supporting direct aggregate disassembly as a disease‐modifying therapeutic strategy for ...
Sara Reithofer   +17 more
wiley   +1 more source

Phytochemical Analysis Using LC–MS/MS and Anticancer Activity of Asphodelus tenuifolius Roots: Cell Cycle Arrest, Apoptosis, and In Silico Insights

open access: yesChemistry &Biodiversity, Volume 23, Issue 9, September 2026.
LC–HRMS/MS profiling of the hydroethanolic root extract of A. tenuifolius identifies 58 metabolites, including luteolin, emodin, luteolin‐7‐O‐β‐D‐glucoside, subaphyllin, and N‐trans‐feruloyltyramine. Integrated biological and computational analyses reveal apoptosis induction, G0/G1 cell‐cycle arrest, and multi‐target interactions, highlighting the ...
Racha Lydia Bouchouka   +7 more
wiley   +1 more source

The Stetter Reaction between Glycolaldehyde and Electron‐Deficient Olefins

open access: yesChemCatChem, Volume 18, Issue 18, 28 September 2026.
Glycolaldehyde is a promising new bio‐derived compound and an attractive substrate for organic synthesis. In the present work, the N‐heterocyclic carbene‐catalyzed umpolung reaction is developed between glycolaldehyde and a range of electron‐deficient olefins such as methyl vinyl ketone, acrylates and several differently substituted chalcones ...
Philip Vinterberg, Robert Madsen
wiley   +1 more source

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