Role of FAAH-like anandamide transporter in anandamide inactivation.
PLoS ONE, 2013 The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung +4 more
doaj +4 more sources
Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study [PDF]
Frontiers in NeurologyObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao +7 more
doaj +2 more sources
Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter. [PDF]
PLoS ONE, 2010 Considerable efforts have been made to characterize the pathways regulating the extracellular levels of the endocannabinoid anandamide. However, none of such pathways has been so argued as the existence of a carrier-mediated transport of anandamide ...
Alessia Ligresti +10 more
doaj +1 more source
High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. [PDF]
PLoS ONE, 2015 BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia.
Orison O Woolcott +18 more
doaj +1 more source
The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. [PDF]
PLoS ONE, 2009 Anandamide is a lipid neurotransmitter which belongs to a class of molecules termed the endocannabinoids involved in multiple physiological functions. Anandamide is readily taken up into cells, but there is considerable controversy as to the nature of ...
Eric Di Pasquale +3 more
doaj +1 more source
Cell Reports, 2020 Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj +1 more source
Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. [PDF]
PLoS ONE, 2013 Impaired vascular function, manifested by an altered ability of the endothelium to release endothelium-derived relaxing factors and endothelium-derived contracting factors, is consistently reported in obesity.
Nubia S Lobato +8 more
doaj +1 more source
Toward an anandamide transporter [PDF]
Proceedings of the National Academy of Sciences, 2005 Almost every step in the elucidation of the structure and mechanism of action of the endocannabinoid system has been plagued by controversy. Although the psychoactive component of marijuana was identified in the mid-1960s (1), it took another two decades to show that it does not act by an unspecific mechanism, but via receptors, now known as the ...
Raphael, Mechoulam, Dale G, Deutsch
openaire +2 more sources
Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. [PDF]
PLoS ONE, 2012 Mammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during their transit through the female genital tract in a process known as capacitation.
Claudia Osycka-Salut +6 more
doaj +1 more source
Anandamide-ceramide interactions in a membrane environment: Molecular dynamic simulations data
Data in Brief, 2017 Anandamide is a lipid neurotransmitter that interacts with various plasma membrane lipids. The data here consists of molecular dynamics simulations of anandamide, C18-ceramide and cholesterol performed in vacuo and within a hydrated palmitoyl-oleoyl ...
Coralie Di Scala +6 more
doaj +1 more source