Results 1 to 10 of about 31,279 (264)

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +2 more sources

Anandamide Revisited: How Cholesterol and Ceramides Control Receptor-Dependent and Receptor-Independent Signal Transmission Pathways of a Lipid Neurotransmitter

Biomolecules, 2018
Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for ...
Coralie Di Scala, Jacques Fantini, Nouara Yahi, Francisco J. Barrantes, Henri Chahinian   +4 more
doaj   +2 more sources

Plasma anandamide concentrations are lower in children with autism spectrum disorder

Molecular Autism, 2018
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication.
Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan, Karen J. Parker   +8 more
doaj   +2 more sources

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial

Biological Psychiatry, 2020
BACKGROUND Posttraumatic stress disorder, an area of large unmet medical needs, is characterized by persistence of fear memories and maladaptive stress responses.
Leah M Mayo, Maria Morena, Gaëlle Augier   +2 more
exaly   +2 more sources

Formation and inactivation of endogenous cannabinoid anandamide in central neurons

Nature, 1994
ANANDAMIDE (N-arachidonoyl-ethanolamine) was recently identified as a brain arachidonate derivative that binds to and activates cannabinoid receptors1–4, yet the mechanisms underlying formation, release and inactivation of this putative messenger ...
Vincenzo Di Marzo, Angelo Fontana, Guido Cimino   +2 more
exaly   +2 more sources

Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

Translational Psychiatry, 2012
Cannabidiol is a component of marijuana that does not activate cannabinoid receptors, but moderately inhibits the degradation of the endocannabinoid anandamide.
F Markus Leweke
exaly   +2 more sources

Circuit-Selective FAAH Inhibition Suppresses Experimental Absence Seizures. [PDF]

CNS Neurosci Ther
Selective inhibition of FAAH with PF‐04457845 enhances endogenous AEA signaling and suppresses absence seizures in Genetic Absence Epilepsy Rats from Strasbourg (GAERS). Video‐EEG recordings demonstrate a marked reduction in SWDs following both acute and subchronic FAAH inhibitions.
Morais TP, Bombardi C, Crunelli V, Di Giovanni G.   +3 more
europepmc   +2 more sources

A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)

Frontiers in Pharmacology, 2016
This perspective was adapted from a Career Achievement Award talk given at the International Cannabinoid Research Society Symposium in Bukovina, Poland on June 27, 2016.
Dale Deutsch
doaj   +2 more sources

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study [PDF]

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +2 more sources

Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities.

Progress in lipid research, 2022
N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N-docosahexaenoylethanolamine (DHEA, synaptamide) and their oxygenated metabolites are a lipid messenger family
E. Mock, Berend Gagestein, Mario van der Stelt   +2 more
semanticscholar   +1 more source