Results 1 to 10 of about 17,707 (220)

Cardiovascular pharmacology of anandamide

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
The fatty acid amide anandamide produces hypotension and a decrease in systemic vascular resistance in vivo. A drop in blood pressure is also seen with synthetic cannabinoid (CB) receptor agonists. The hypotensive responses to anandamide and synthetic cannabinoids are absent in CB1 receptor gene knockout mice. In isolated arteries and perfused vascular
Edward D, Högestätt, P M, Zygmunt
core   +4 more sources

High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. [PDF]

PLoS ONE, 2015
BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia.
Orison O Woolcott, Joyce M Richey, Morvarid Kabir, Robert H Chow, Malini S Iyer, Erlinda L Kirkman, Darko Stefanovski, Maya Lottati, Stella P Kim, L Nicole Harrison, Viorica Ionut, Dan Zheng, Isabel R Hsu, Karyn J Catalano, Jenny D Chiu, Heather Bradshaw, Qiang Wu, Cathryn M Kolka, Richard N Bergman   +18 more
doaj   +2 more sources

Binding of anandamide to bovine serum albumin

Journal of Lipid Research, 2003
The endocannabinoid anandamide is of lipid nature and may thus bind to albumin in the vascular system, as do fatty acids. The knowledge of the free water-phase concentration of anandamide is essential for the investigations of its transfer from the ...
Inge N. Bojesen, Harald S. Hansen
doaj   +2 more sources

Role of FAAH-like anandamide transporter in anandamide inactivation.

PLoS ONE, 2013
The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung, Matthew W Elmes, Sherrye T Glaser, Dale G Deutsch, Martin Kaczocha   +4 more
doaj   +4 more sources

Anandamide-ceramide interactions in a membrane environment: Molecular dynamic simulations data

Data in Brief, 2017
Anandamide is a lipid neurotransmitter that interacts with various plasma membrane lipids. The data here consists of molecular dynamics simulations of anandamide, C18-ceramide and cholesterol performed in vacuo and within a hydrated palmitoyl-oleoyl ...
Coralie Di Scala, Morgane Mazzarino, Nouara Yahi, Karine Varini, Nicolas Garmy, Jacques Fantini, Henri Chahinian   +6 more
doaj   +2 more sources

Anandamide: some like it hot

Trends in Pharmacological Sciences, 2001
Anandamide was the first endogenous ligand of cannabinoid receptors to be discovered in 1992. Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1). Whether anandamide is a physiological VR1 ligand is controversial.
Di Marzo V, Bisogno T, De Petrocellis L
openaire   +3 more sources

Oxygenation of Anandamide by Lipoxygenases

, 2016
The endocannabinoids anandamide and 2-arachidonoylglycerol are not only metabolized by serine hydrolases, such as fatty acid amide hydrolase, monoacylglycerol lipase, and α,β-hydrolases 6 and 12, but they also serve as substrates for cyclooxygenases, cytochrome P450s, and lipoxygenases.
Zadelhoff, G. van, Stelt, M. van der
openaire   +7 more sources

N-Arachidonoyl-phosphatidylethanolamide phospholipase D activation by muscarinic receptors. [PDF]

J Physiol
Abstract figure legend Activating muscarinic M3 receptors activates Gq‐pathway signalling, including the activation of phospholipase C (PLC) and release of calcium from internal stores as shown in the upper panel. It remains unclear whether the calcium acts on N‐arachidonoyl‐phosphatidylethanolamide phospholipase D (NAPE‐PLD) itself or upstream at N ...
Murataeva N, Schmitt C, Hyman E, Wager-Miller J, Matthews I, Cai R, Cai S, Li Y, Mackie K, Straiker A.   +9 more
europepmc   +2 more sources

Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter. [PDF]

PLoS ONE, 2010
Considerable efforts have been made to characterize the pathways regulating the extracellular levels of the endocannabinoid anandamide. However, none of such pathways has been so argued as the existence of a carrier-mediated transport of anandamide ...
Alessia Ligresti, Luciano De Petrocellis, Dolores Hernán Pérez de la Ossa, Rosario Aberturas, Luigia Cristino, Aniello Schiano Moriello, Andrea Finizio, M Esther Gil, Ana-Isabel Torres, Jesús Molpeceres, Vincenzo Di Marzo   +10 more
doaj   +1 more source

The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. [PDF]

PLoS ONE, 2009
Anandamide is a lipid neurotransmitter which belongs to a class of molecules termed the endocannabinoids involved in multiple physiological functions. Anandamide is readily taken up into cells, but there is considerable controversy as to the nature of ...
Eric Di Pasquale, Henri Chahinian, Patrick Sanchez, Jacques Fantini   +3 more
doaj   +1 more source