Results 1 to 10 of about 41,114 (259)

Role of the Endocannabinoid System in the Adipose Tissue with Focus on Energy Metabolism

open access: yesCells, 2021
The endocannabinoid system is involved in a wide range of processes including the control of energy acquisition and expenditure. Endocannabinoids and their receptors are present in the central nervous system but also in peripheral tissues, notably the ...
Nicolas Flamand   +2 more
exaly   +3 more sources

From endocannabinoid profiling to 'endocannabinoid therapeutics'

open access: yesCurrent Opinion in Chemical Biology, 2009
The discovery of the endocannabinoid signalling system, that is, of cannabinoid receptors, their endogenous ligands, known as endocannabinoids, and of endocannabinoid anabolic and catabolic enzymes, raised several questions regarding the ...
Petrosino S, Di Marzo V, Ligresti A
core   +5 more sources

The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity

open access: yesFrontiers in Aging Neuroscience, 2022
N-oleoylglycine (OlGly) is a lipid mediator that belongs to the expanded version of the endocannabinoid (eCB) system, the endocannabinoidome (eCBome), which has recently gained increasing attention from the scientific community for its protective effects
Anna Lauritano   +9 more
doaj   +1 more source

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

open access: yesBiomolecules, 2022
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the transition to ARDS is principally due to the occurrence of a cytokine storm ...
Aniello Schiano Moriello   +8 more
doaj   +1 more source

The Endocannabinoid System: A Bridge between Alzheimer’s Disease and Gut Microbiota

open access: yesLife, 2021
Alzheimer’s disease (AD) is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia over time. The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during ...
Tiziana Bisogno   +2 more
doaj   +1 more source

Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time

open access: yesCells, 2021
Bone is a highly complex and metabolically active tissue undergoing a continuous remodeling process, which endures throughout life. A complex cell-signaling system that plays role in regulating different physiological processes, including bone remodeling,
Magdalena Kostrzewa   +6 more
doaj   +1 more source

Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint

open access: yesAnimals, 2022
There is growing evidence that perturbation of the gut microbiome, known as “dysbiosis”, is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract.
Aniello Schiano Moriello   +2 more
doaj   +1 more source

Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

open access: yesCell Death and Disease, 2023
Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients.
Hilal Kalkan   +9 more
doaj   +1 more source

Endocannabinoids and Reproduction [PDF]

open access: yesInternational Journal of Endocrinology, 2014
Infertility is a worldwide reproductive health problem whose consequences have deep psychological and social impact in health, demographic change, and wellbeing. Thus, the knowledge of basic, conserved modulators of reproduction might contribute to the discovery of new potential target for the exploitation of drugs to treat infertility in humans ...
Rosaria Meccariello   +3 more
openaire   +4 more sources

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

open access: yesFrontiers in Synaptic Neuroscience, 2021
Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice.
Lea Tunisi   +12 more
doaj   +1 more source

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