Results 1 to 10 of about 26,556 (159)

The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity

Frontiers in Aging Neuroscience, 2022
N-oleoylglycine (OlGly) is a lipid mediator that belongs to the expanded version of the endocannabinoid (eCB) system, the endocannabinoidome (eCBome), which has recently gained increasing attention from the scientific community for its protective effects
Anna Lauritano, Irene Cipollone, Roberta Verde, Hilal Kalkan, Claudia Moriello, Fabio Arturo Iannotti, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Fabiana Piscitelli   +9 more
doaj   +1 more source

First Evidence of the Protective Effects of 2-Pentadecyl-2-Oxazoline (PEA-OXA) in In Vitro Models of Acute Lung Injury

Biomolecules, 2022
Acute respiratory distress syndrome (ARDS) is a serious inflammatory lung disorder and a complication of SARS-CoV-2 infection. In patients with severe SARS-CoV-2 infection, the transition to ARDS is principally due to the occurrence of a cytokine storm ...
Aniello Schiano Moriello, Fiorentina Roviezzo, Fabio Arturo Iannotti, Giuseppina Rea, Marco Allarà, Rosa Camerlingo, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino   +8 more
doaj   +1 more source

Modulation of Endocannabinoid Tone in Osteoblastic Differentiation of MC3T3-E1 Cells and in Mouse Bone Tissue over Time

Cells, 2021
Bone is a highly complex and metabolically active tissue undergoing a continuous remodeling process, which endures throughout life. A complex cell-signaling system that plays role in regulating different physiological processes, including bone remodeling,
Magdalena Kostrzewa, Ali Mokhtar Mahmoud, Roberta Verde, Federica Scotto di Carlo, Fernando Gianfrancesco, Fabiana Piscitelli, Alessia Ligresti   +6 more
doaj   +1 more source

The Endocannabinoid System: A Bridge between Alzheimer’s Disease and Gut Microbiota

Life, 2021
Alzheimer’s disease (AD) is a neurodegenerative disease that progresses from mild cognitive impairment to severe dementia over time. The main clinical hallmarks of the disease (e.g., beta-amyloid plaques and neurofibrillary tangles) begin during ...
Tiziana Bisogno, Anna Lauritano, Fabiana Piscitelli   +2 more
doaj   +1 more source

Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint

Animals, 2022
There is growing evidence that perturbation of the gut microbiome, known as “dysbiosis”, is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract.
Aniello Schiano Moriello, Vincenzo Di Marzo, Stefania Petrosino   +2 more
doaj   +1 more source

Dysfunctional endocannabinoid CB1 receptor expression and signaling contribute to skeletal muscle cell toxicity induced by simvastatin

Cell Death and Disease, 2023
Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe, although muscular toxicity occurs in about 1 in 10.000 patients.
Hilal Kalkan, Elisabetta Panza, Ester Pagano, Giuseppe Ercolano, Claudia Moriello, Fabiana Piscitelli, Mónika Sztretye, Raffaele Capasso, Vincenzo Di Marzo, Fabio Arturo Iannotti   +9 more
doaj   +1 more source

Endocannabinoid Overload [PDF]

Molecular Pharmacology, 2010
The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman, Jacqueline L, Blankman, Benjamin F, Cravatt   +2 more
openaire   +2 more sources

Endocannabinoids and Reproduction [PDF]

International Journal of Endocrinology, 2014
Infertility is a worldwide reproductive health problem whose consequences have deep psychological and social impact in health, demographic change, and wellbeing. Thus, the knowledge of basic, conserved modulators of reproduction might contribute to the discovery of new potential target for the exploitation of drugs to treat infertility in humans ...
Rosaria Meccariello, Natalia Battista, Heather B. Bradshaw, Haibin Wang   +3 more
openaire   +4 more sources

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

Frontiers in Synaptic Neuroscience, 2021
Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice.
Lea Tunisi, Lea Tunisi, Livia D'Angelo, Alba Clara Fernández-Rilo, Nicola Forte, Nicola Forte, Fabiana Piscitelli, Roberta Imperatore, Paolo de Girolamo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Luigia Cristino   +12 more
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Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy

EMBO Molecular Medicine, 2023
Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites are ...
Hilal Kalkan, Ester Pagano, Debora Paris, Elisabetta Panza, Mariarosaria Cuozzo, Claudia Moriello, Fabiana Piscitelli, Armita Abolghasemi, Elisabetta Gazzerro, Cristoforo Silvestri, Raffaele Capasso, Andrea Motta, Roberto Russo, Vincenzo Di Marzo, Fabio Arturo Iannotti   +14 more
doaj   +1 more source