Results 41 to 50 of about 54,731 (237)

Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer

OncoImmunology, 2021
Monoacylglycerol lipase (MGL) expressed in cancer cells influences cancer pathogenesis but the role of MGL in the tumor microenvironment (TME) is less known.
Melanie Kienzl, Carina Hasenoehrl, Kathrin Maitz, Arailym Sarsembayeva, Ulrike Taschler, Paulina Valadez-Cosmes, Oliver Kindler, Dusica Ristic, Sofia Raftopoulou, Ana Santiso, Thomas Bärnthaler, Luka Brcic, Lisa Hahnefeld, Robert Gurke, Dominique Thomas, Gerd Geisslinger, Julia Kargl, Rudolf Schicho   +17 more
doaj   +1 more source

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno, Chiang, Cravatt, Cravatt, De Marchi, Despres, Devane, Di, Di Marzo, Di Marzo, Fernandez, Freund, Giuffrida, Giuffrida, Habayeb, Klein, Klein, Maccarrone, Matsuda, Munro, Obata, Parolaro, Pertwee, Randall, Sipe, Sparling, Sugiura, Wagner, Wagner, Walker, Yamaji   +30 more
core   +1 more source

The Endocannabinoid System and Sex Steroid Hormone-Dependent Cancers

International Journal of Endocrinology, 2013
The “endocannabinoid system (ECS)” comprises the endocannabinoids, the enzymes that regulate their synthesis and degradation, the prototypical cannabinoid receptors (CB1 and CB2), some noncannabinoid receptors, and an, as yet, uncharacterised transport ...
Thangesweran Ayakannu, Anthony H. Taylor, Timothy H. Marczylo, Jonathon M. Willets, Justin C. Konje   +4 more
doaj   +1 more source

Altered Expression of the CB1 Cannabinoid Receptor in the Triple Transgenic Mouse Model of Alzheimer's Disease [PDF]

, 2014
The endocannabinoid system has gained much attention as a new potential pharmacotherapeutic target in various neurodegenerative diseases, including Alzheimer's disease (AD).
*EQUAL CONTRIBUTION, Adele Romano*, Angelo Michele Lavecchia, Caterina Grillo, F.m. Laferla, Fabio Altieri, Gaurav Bedse*, Gianluigi Vendemiale, Lorenzo Federico Pace, M.r. Elphick, Silvana Gaetani, Silvia Cianci, Tommaso Cassano   +12 more
core   +1 more source

mGluR5 in ECCCK to BLA Circuit Modulates Depressive‐Like Phenotypes through CCK Signaling

Advanced Science, EarlyView.
Dysregulation of mGluR5 and CCK signaling contributes to major depressive disorder, yet circuit‐level mechanisms remain unclear. Here, the ECCCK→BLA pathway is identified as a critical regulator of affective behavior. mGluR5 modulates synaptic function and CCK signaling within this circuit, controlling stress susceptibility and depressive‐like states ...
Muhammad Asim, Huajie Wang, Gao Qianqian, Abdul Waris, Jufang He   +4 more
wiley   +1 more source

Effect of Non-psychotropic Plant-derived Cannabinoids on Bladder Contractility: Focus on Cannabigerol

Natural Product Communications, 2015
There are anecdotal reports that some Cannabis preparations may be useful for bladder dysfunctions. Here, we investigated the effect of a number of non-psychotropic phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), cannabidivarin (CBDV), Δ
Ester Pagano, Vittorino Montanaro, Antonio di Girolamo, Antonio Pistone, Vincenzo Altieri, Jordan K. Zjawiony, Angelo A. Izzo, Raffaele Capasso   +7 more
doaj   +1 more source

The Neuroprotective Effect of NEUROMIDE, a Compound Bioidentical to Commensal Bacteria Metabolites

Life, 2022
GPR119 is a novel cannabinoid receptor that is primarily expressed in the pancreas and gastrointestinal tract and has beneficial effects on glucose homeostasis exerted through the stimulation of GLP-1 secretion, as demonstrated in the rodent brain. GLP-1
Yoonhee Seo, Hyunji Tak, Dohee Park, Hyejin Song, Sooyoung Choe, Chaehyeong Park, Byeongdeog Park   +6 more
doaj   +1 more source

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
Adams, Agrawal, Ahern, Alger, Armstrong, Arnone, Avraham, Bachur, Baker, Baker, Barbano, Basavarajappa, Basavarajappa, Ben Amar, Ben-Zvi, Berridge, Berridge, Bisogno, Blankman, Bortolato, Breivogel, Brown, Brown, Burkey, Cadas, Cahn, Chan, Childers, Clark, Comelli, Consroe, Costiniuk, Cota, Cota, Cota, Cravatt, Davis, Davis, De Filippis, De Petrocellis, De Petrocellis, Deadwyler, Dennis, Deutsch, Devane, Devane, Dewey, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Di Marzo, Elmquist, Engeli, Evans, Fadda, Farrimond, Farrimond, Felder, Fong, Fonseca, Fredriksson, Freund, Gaetani, Gallate, Gaoni, Gaoni, Gaoni, Gardner, Gatley, Gerdeman, Gill, Glass, Glick, Gomez, Gong, Goutopoulos, Grant, Hao, Henstridge, Henstridge, Herkenham, Herkenham, Higgs, Hohmann, Holland, Hollister, Horswill, Hosohata, Howlett, Howlett, Howlett, Huffman, Hughes, Ishiguro, Izzo, Jamshidi, Jarrett, Jarrett, Jin, Kapur, King, Kirby, Kirkham, Kirkham, Kirkham, Kirkham, Kirkham, Koch, Lambert, Landsman, Lauckner, Lauckner, Ligresti, Little, Liu, Long, Ma, Maccarrone, Maccarrone, Mackie, Mackie, Makriyannis, Martin, Mathes, Matsuda, Mechoulam, Mechoulam, Moldrich, Morgan, Morley, Munro, Naidu, Ning, Ohno-Shosaku, Okamoto, Okamoto, Okamoto, Onaivi, Onaivi, Onaivi, Osei-Hyiaman, Overton, Overton, Oz, Pacheco, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Pertwee, Petitet, Petrosino, Pietr, Piomelli, Piomelli, Piomelli, Pope, Pryce, Pryce, Putney, Rao, Riedel, Rinaldi-Carmona, Rinaldi-Carmona, Rodriguez de Fonseca, Ronesi, Ross, Ross, Ryan, Ryberg, Sanger, Sawzdargo, Schweitzer, Showalter, Simiand, Sink, Sofia, Soga, Solinas, Staton, Stratford, Sugiura, Sugiura, Sugiura, Südhof, Takeda, Thomas, Thornton-Jones, Tramer, Tsou, Turu, Van Gaal, Van Sickle, Vandevoorde, Walsh, Wang, Werner, Whalley, Wiley, Wilkinson, Williams, Williams, Williams, Williams, Williamson, Wilson, Woolridge, Yamauchi, Yan, Yates, Yoshida, Zhu   +215 more
core   +3 more sources

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

AGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter   +4 more
wiley   +1 more source

2-arachidonoylglycerol metabolism is differently modulated by oligomeric and fibrillar conformations of amyloid beta in synaptic terminals [PDF]

, 2017
Alzheimer´s disease (AD) is the most prevalent disorder of senile dementia mainly characterized by amyloid-beta peptide (Aβ) deposits in the brain. Cannabinoids are relevant to AD as they exert several beneficial effects in many models of this disease ...
Gaveglio, Virginia Lucía, Giusto, Norma Maria, Pascual, Ana Clara, Pasquaré, Susana Juana   +3 more
core   +1 more source