Results 1 to 10 of about 6,653 (129)

Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity [PDF]

European Psychiatry, 2023
Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism.
Isabel Baenas, Romina Miranda-Olivos, Roser Granero, Neus Solé-Morata, Isabel Sánchez, Antoni Pastor, Amparo del Pino-Gutiérrez, Ester Codina, Francisco J. Tinahones, José A. Fernández-Formoso, Núria Vilarrasa, Fernando Guerrero-Pérez, Rafael Lopez-Urdiales, Núria Virgili, Carles Soriano-Mas, Susana Jiménez-Murcia, Rafael de la Torre, Fernando Fernández-Aranda   +17 more
doaj   +2 more sources

Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation [PDF]

Scientific Reports
2-arachidonoylglycerol (2-AG) is an endogenous modulator of inflammatory processes. Recent studies demonstrate its key role in inflammatory cardiovascular diseases, such as atherosclerosis and left ventricular remodelling. However, whether 2-AG acts as a
Moritz Nöthel, Franziska Dorer, Alexandru Odainic, Carolyn Krause, Marie Rüthing, Jasper Spitzer, Ulrike Strube, Theresia Weise, Dieter Lütjohann, Georg Nickenig, Susanne V. Schmidt, Julian Jehle   +11 more
doaj   +2 more sources

Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlate in gambling disorder [PDF]

European Psychiatry, 2023
Introduction Different components of the endocannabinoid (eCB) system such as their most well-known endogenous ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been implicated in brain reward pathways.
Isabel Baenas, Neus Solé-Morata, Roser Granero, Fernando Fernández-Aranda, Mitona Pujadas, Bernat Mora-Maltas, Ignacio Lucas, Mónica Gómez-Peña, Laura Moragas, Amparo del Pino-Gutiérrez, Javier Tapia, Rafael de la Torre, Marc N. Potenza, Susana Jiménez-Murcia   +13 more
doaj   +2 more sources

Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women

Molecular Metabolism, 2017
Objective: The endocannabinoid system hypertonicity features obesity. Excess circulating 2-arachidonoylglycerol was variously associated with obesity-related metabolic impairment; however, unstandardized experimental and analytical settings have clouded ...
Flaminia Fanelli, Marco Mezzullo, Ilaria Belluomo   +2 more
exaly   +3 more sources

New Perspectives in the Studies on Endocannabinoid and Cannabis: 2-Arachidonoylglycerol as a Possible Novel Mediator of Inflammation

Journal of Pharmacological Sciences, 2004
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors. To date, two types of cannabinoid receptors (CB1 and CB2) have been identified. The CB1 receptor is assumed to be involved in the attenuation of synaptic transmission.
Takayuki Sugiura, Saori Oka, Maiko Gokoh   +2 more
exaly   +3 more sources

Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. [PDF]

PLoS ONE, 2018
BackgroundThe endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been
Julian Jehle, Benedikt Schöne, Sayeh Bagheri, Elina Avraamidou, Melina Danisch, Imke Frank, Philipp Pfeifer, Laura Bindila, Beat Lutz, Dieter Lütjohann, Andreas Zimmer, Georg Nickenig   +11 more
doaj   +2 more sources

An Innovative Sandwich Type Biosensor towards Sensitive and Selective Monitoring of 2-Arachidonoylglycerol in Human Plasma Samples Using P(β-CD)-AuNPs-DDT as Amplificant Agent: A New Immuno-Platform for the Recognition of Endocannabinoids in Real Samples [PDF]

Biosensors, 2022
In this work, 2-AG was successfully detected in human plasma samples using a new sandwich-type electrochemical immune device based on poly-β-cyclodextrin P(β-CD) functionalized with AuNPs-DDT and toluidine blue.
Nastaran Aletaha, Kambiz Ghaseminasab, Mohammad Hasanzadeh, Fereshteh Kohansal, Yuqian Liu, Farzad Seidi   +5 more
doaj   +2 more sources

Direct modulation of human GABA-A α1β2γ2 receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development [PDF]

Frontiers in Neuroscience
Anxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain effective anxiolytics, their clinical utility is limited by sedation, cognitive ...
Edgar Mixcoha, Edgar Mixcoha, Anabel Flores-Zamora, Ricardo Hernández-Miramontes, Jorge Alberto Hernández-Calderón, Susana Martiñón, Susana Martiñón   +6 more
doaj   +2 more sources

Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia [PDF]

Frontiers in Neuroscience, 2019
Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the ...
Urszula Hohmann, Markus Pelzer, Joshua Kleine, Tim Hohmann, Chalid Ghadban, Faramarz Dehghani   +5 more
doaj   +2 more sources

The neuroprotective mechanism of 2-arachidonoylglycerol 2-AG against non-caspase-dependent apoptosis in mice hippocampal neurons following MCAO [PDF]

Neuropsychiatric Disease and Treatment, 2019
He-Ying Zhong, Zhou Yang, Zhen Qiu, Shao-Qing Lei, Zhong-Yuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of ChinaCorrespondence: Zhong-Yuan XiaDepartment of Anesthesiology, Renmin ...
Zhong HY, Yang Z, Qiu Z, Lei SQ, Xia ZY
doaj   +2 more sources