Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation [PDF]
Scientific Reports2-arachidonoylglycerol (2-AG) is an endogenous modulator of inflammatory processes. Recent studies demonstrate its key role in inflammatory cardiovascular diseases, such as atherosclerosis and left ventricular remodelling. However, whether 2-AG acts as a
Moritz Nöthel +11 more
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Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. [PDF]
PLoS ONE, 2018 BackgroundThe endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been
Julian Jehle +11 more
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Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity [PDF]
European Psychiatry, 2023 Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism.
Isabel Baenas +17 more
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Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlate in gambling disorder [PDF]
European Psychiatry, 2023 Introduction Different components of the endocannabinoid (eCB) system such as their most well-known endogenous ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been implicated in brain reward pathways.
Isabel Baenas +13 more
doaj +2 more sources
Molecular Metabolism, 2017 Objective: The endocannabinoid system hypertonicity features obesity. Excess circulating 2-arachidonoylglycerol was variously associated with obesity-related metabolic impairment; however, unstandardized experimental and analytical settings have clouded ...
Flaminia Fanelli +2 more
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Photorelease of 2-Arachidonoylglycerol in Live Cells. [PDF]
J Am Chem Soc, 2019 2-Arachidonoylglycerol (2-AG) is acting as a full agonist of cannabinoid receptor 1 and 2. Direct manipulation of 2-AG levels is a challenging task. The amphiphilic properties and the instability of 2-AG in aqueous media complicate its use as a drug-like molecule.
Laguerre A +4 more
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An Innovative Sandwich Type Biosensor towards Sensitive and Selective Monitoring of 2-Arachidonoylglycerol in Human Plasma Samples Using P(β-CD)-AuNPs-DDT as Amplificant Agent: A New Immuno-Platform for the Recognition of Endocannabinoids in Real Samples [PDF]
Biosensors, 2022 In this work, 2-AG was successfully detected in human plasma samples using a new sandwich-type electrochemical immune device based on poly-β-cyclodextrin P(β-CD) functionalized with AuNPs-DDT and toluidine blue.
Nastaran Aletaha +5 more
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A role for monoglyceride lipase in 2-arachidonoylglycerol inactivation [PDF]
Chemistry and Physics of Lipids, 2002 2-Arachidonoylglycerol (2-AG) is a naturally occurring monoglyceride that activates cannabinoid receptors and meets several key requisites of an endogenous cannabinoid substance. It is present in the brain (where its levels are 170-folds higher than those of anandamide), is produced by neurons in an activity- and calcium-dependent manner, and is ...
Tamás F Freund, Daniele Piomelli
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Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand
FEBS Letters, 1998 Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2‐arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis. A cDNA for a rat liver enzyme hydrolyzing anandamide as well as oleamide was overexpressed in COS‐7 cells.
Goparaju, Sravan Kumar +3 more
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Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia [PDF]
Frontiers in Neuroscience, 2019 Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the ...
Urszula Hohmann +5 more
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