Elevated levels of 2-arachidonoylglycerol promote atherogenesis in ApoE-/- mice. [PDF]
PLoS ONE, 2018 BackgroundThe endocannabinoid (eCB) 2-arachidonoylglycerol (2-AG) is a known modulator of inflammation and ligand to both, pro-inflammatory cannabinoid receptor 1 (CB1) and anti-inflammatory CB2. While the role of both receptors in atherogenesis has been
Julian Jehle +11 more
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Unbiased assessment of 2-arachidonoylglycerol in cardiovascular inflammation [PDF]
Scientific Reports2-arachidonoylglycerol (2-AG) is an endogenous modulator of inflammatory processes. Recent studies demonstrate its key role in inflammatory cardiovascular diseases, such as atherosclerosis and left ventricular remodelling. However, whether 2-AG acts as a
Moritz Nöthel +11 more
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Plasma 2-arachidonoylglycerol is a biomarker of age and menopause related insulin resistance and dyslipidemia in lean but not in obese men and women [PDF]
Molecular Metabolism, 2017 Objective: The endocannabinoid system hypertonicity features obesity. Excess circulating 2-arachidonoylglycerol was variously associated with obesity-related metabolic impairment; however, unstandardized experimental and analytical settings have clouded ...
Flaminia Fanelli +2 more
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Association of anandamide and 2-arachidonoylglycerol concentrations with clinical features and body mass index in eating disorders and obesity [PDF]
European Psychiatry, 2023 Background Anandamide (AEA) and 2-arachidonoylglycerol (2-AG) play a pivotal role in stimulating motivational behavior toward food and energy metabolism.
Isabel Baenas +17 more
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Anandamide and 2-arachidonoylglycerol baseline plasma concentrations and their clinical correlate in gambling disorder [PDF]
European Psychiatry, 2023 Introduction Different components of the endocannabinoid (eCB) system such as their most well-known endogenous ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), have been implicated in brain reward pathways.
Isabel Baenas +13 more
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Journal of Pharmacological Sciences, 2004 2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors. To date, two types of cannabinoid receptors (CB1 and CB2) have been identified. The CB1 receptor is assumed to be involved in the attenuation of synaptic transmission.
Takayuki Sugiura +2 more
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An Innovative Sandwich Type Biosensor towards Sensitive and Selective Monitoring of 2-Arachidonoylglycerol in Human Plasma Samples Using P(β-CD)-AuNPs-DDT as Amplificant Agent: A New Immuno-Platform for the Recognition of Endocannabinoids in Real Samples [PDF]
Biosensors, 2022 In this work, 2-AG was successfully detected in human plasma samples using a new sandwich-type electrochemical immune device based on poly-β-cyclodextrin P(β-CD) functionalized with AuNPs-DDT and toluidine blue.
Nastaran Aletaha +5 more
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Direct modulation of human GABA-A α1β2γ2 receptors by the endocannabinoid 2-arachidonoylglycerol: implications for cannabinoid-related ligands and limitations for anxiolytic drug development [PDF]
Frontiers in NeuroscienceAnxiety disorders are associated with impaired inhibitory neurotransmission mediated by γ-aminobutyric acid type A (GABA-A) receptors. Although benzodiazepines remain effective anxiolytics, their clinical utility is limited by sedation, cognitive ...
Edgar Mixcoha +6 more
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Opposite Effects of Neuroprotective Cannabinoids, Palmitoylethanolamide, and 2-Arachidonoylglycerol on Function and Morphology of Microglia [PDF]
Frontiers in Neuroscience, 2019 Various studies performed in cultured cells and in in vivo models of neuronal damage showed that cannabinoids exert a neuroprotective effect. The increase in cannabinoids and cannabinoid like substances after stroke has been postulated to limit the ...
Urszula Hohmann +5 more
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The neuroprotective mechanism of 2-arachidonoylglycerol 2-AG against non-caspase-dependent apoptosis in mice hippocampal neurons following MCAO [PDF]
Neuropsychiatric Disease and Treatment, 2019 He-Ying Zhong, Zhou Yang, Zhen Qiu, Shao-Qing Lei, Zhong-Yuan XiaDepartment of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of ChinaCorrespondence: Zhong-Yuan XiaDepartment of Anesthesiology, Renmin ...
Zhong HY, Yang Z, Qiu Z, Lei SQ, Xia ZY
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