Results 41 to 50 of about 17,658,570 (203)

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken   +19 more
core   +1 more source

Circulating Endocannabinoids in Canine Multicentric Lymphoma Patients

Frontiers in Veterinary Science, 2022
The endocannabinoid system is increasingly being implicated in the pathogenesis and progression of various human cancers. Specifically, increased levels of 2-arachidonoylglycerol (2-AG) and oleoythanolamide (OEA) have been demonstrated in human diffuse ...
Jennifer K. Hay, Samuel E. Hocker, Samuel E. Hocker, Gabrielle Monteith, J. Paul Woods   +4 more
doaj   +1 more source

Placental DAGLβ regulates 2-arachidonoylglycerol (2-AG) levels and is involved in pregnancy induced inflammation

, 2021
Diacylglycerollipase alpha/beta (DAGLα/β) are two sequence-related serine hydrolases, biosynthesizing 2-arachidonoylglycerol (2-AG). 2-AG, one of the main endocannabinoids, and its esterified fatty acid arachidonic acid serve as substrates for pro ...
Bärnthaler, Thomas; orcid:, Girgis, Nermeen, Birner-Grünberger, Ruth; orcid:, Hirschmugl, Birgit, van der Wel, Tom; orcid:, Wadsack, Christian, Berger, Natascha, Gindlhuber, Juergen, Zimmermann, Robert, van der Stelt, Mario; orcid:   +9 more
core   +1 more source

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases

Molecules, 2021
Neurological and neurodegenerative diseases are debilitating conditions, and frequently lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective ...
Anca Zanfirescu, Anca Ungurianu, Dragos Paul Mihai, Denise Radulescu, George Mihai Nitulescu   +4 more
doaj   +1 more source

Anandamide amidohydrolase reacting with 2-arachidonoylglycerol, another cannabinoid receptor ligand

, 1997
Two endogenous ligands for cannabinoid receptors, anandamide (arachidonylethanolamide) and 2-arachidonoylglycerol, lose their biological activities by enzymatic hydrolysis.
Hiroko Yamaguchi, Goparaju, Sravan Kumar, Yamamoto, Shozo, Shozo Yamamoto, Sravan Kumar Goparaju, Natsuo Ueda, Ueda, Natsuo, Yamaguchi, Hiroko   +7 more
core   +1 more source

2-Arachidonoylglycerol (2-AG) membrane transport: History and outlook [PDF]

The AAPS Journal, 2006
Only a few studies have addressed the transport of 2-arachidonoylglycerol (2-AG), a naturally occurring agonist for cannabinoid receptors. Based upon saturation kinetics, these early reports have proposed that 2-AG enters the cell by a specific 2-AG transporter, via the putative anandamide transporter, or by simple diffusion. In this review, the uptake
Anita, Hermann, Martin, Kaczocha, Dale G, Deutsch   +2 more
openaire   +2 more sources

2-Arachidonoylglycerol, 1-arachidonoylglycerol and the stable 2-arachidonoylglycerol analog noladin ether activate native TRPV1.

, 2013
(A) Concentration-response curves for 2-arachidonoylglycerol (2-AG), 1-arachidonoylglycerol (1-AG) and noladin ether (NE) in the presence and absence of the TRPV1 antagonist capsazepine. Control experiments were performed in the presence of vehicle (0.1%
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Andres Beiras Fernandez, Roland Toth, Markus Giehl, Weis, Florian, Erich Kilger, Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Schelling, Gustav, Florian Weis, Strewe, Claudia, Toth, Roland, Mirjam Schopp, Gustav Schelling, Daniela Hauer, Kilger, Erich, Schopp, Mirjam, Hauer, Daniela, Claudia Strewe   +18 more
core   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

2-Arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism [PDF]

Cell Metabolism, 2012
The endocannabinoid system plays a critical role in the control of energy homeostasis, but the identity and localization of the endocannabinoid signal involved remain unknown. In the present study, we developed transgenic mice that overexpress in forebrain neurons the presynaptic hydrolase, monoacylglycerol lipase (MGL), which deactivates the ...
Jung, Kwang-Mook, Clapper, Jason R, Fu, Jin, D'Agostino, Giuseppe, Guijarro, Ana, Thongkham, Dean, Avanesian, Agnesa, Astarita, Giuseppe, DiPatrizio, Nicholas V, Frontini, Andrea, Cinti, Saverio, Diano, Sabrina, Piomelli, Daniele   +12 more
openaire   +6 more sources