Results 41 to 50 of about 24,579,074 (168)

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Journal of Neuroinflammation, 2018
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins ...
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad   +10 more
doaj   +1 more source

The ongoing oleoylethanolamide story: Therapeutic implications in the control of obesity and its comorbidities

British Journal of Pharmacology, EarlyView.
The global burden of obesity continues to rise, demanding effective pharmacological strategies for individuals in whom prevention alone is insufficient. Recent incretin‐based and multi‐agonist therapies have delivered unprecedented weight loss, demonstrating that the simultaneous modulation of multiple metabolic pathways can optimize body weight ...
Marzia Friuli, Alessia Campagna, Barbara Eramo, Christian Sepe, Annarita Zuena, Silvana Gaetani, Adele Romano   +6 more
wiley   +1 more source

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

, 2011
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point to a protective role of CB(1) and CB(2) cannabinoid receptor activation in IBD experimental ...
Delzenne, Nathalie M., Al Houayek, Mireille, Muccioli, Giulio, Patrice D. Cani, Mireille Alhouayek, Lambert, Didier, Cani, Patrice D., Nathalie M. Delzenne, Didier M. Lambert, Giulio G. Muccioli   +9 more
core   +1 more source

Inverse correlation between plasma 2‐arachidonoylglycerol levels and subjective severity of depression

, 2021
Objective: Endocannabinoids have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and might represent potential targets for therapeutic intervention.
Valentina Cuoco, Bowles, Nicole P., Francesca Pacitti, Fanelli, Flaminia, Dionysios Xenos, Michela Marconi, Nasca, Carla, Giuseppe Bersani, Carla Nasca, Di Lallo, Valentina D., Pacitti, Francesca, Flaminia Fanelli, Angela Iannitelli, Ilaria Belluomo, Nicoletti, Ferdinando, Bersani, Giuseppe, Caroti, Eleonora, Iannitelli, Angela, Nicole P. Bowles, Belluomo, Ilaria, Bigio, Benedetta, Cuoco, Valentina, Weisz, Filippo, Eleonora Caroti, Valentina D. Di Lallo, Benedetta Bigio, Ferdinando Nicoletti, Filippo Weisz, Marconi, Michela, Adele Quartini, Xenos, Dionysios, Quartini, Adele   +31 more
core   +2 more sources

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Changes of endocannabinoid plasma levels following type I trauma [PDF]

, 2012
The endocannabinoid system has emerged as one of the most important facilitators of stress adaptation in the body. So far, little to no research took place concerning the endocannabinoid response to stress in humans.
Heimendahl, Jenny von
core   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy

, 2014
The endocannabinoid system is implicated in, and regulates, several physiological processes, ranging from food intake and energy balance to pain and inflammation.
Al Houayek, Mireille, Muccioli, Giulio, Masquelier, Julien   +2 more
core   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

The regulation of endocannabinoids after neuronal damage and the neuroprotective impact of GPR55 in organotypic hippocampal slice cultures [PDF]

, 2013
Endocannabinoids (eCB) are signaling lipids and became known for their importance in the central nervous system as well as in immune defense. Beneficial effects of eCB are shown in processes of excitotoxic lesion, secondary damage and neuronal plasticity
Kallendrusch, Sonja
core