Results 41 to 50 of about 6,728 (169)

Production of the endocannabinoids anandamide and 2‐arachidonoylglycerol by endothelial progenitor cells [PDF]

FEBS Letters, 2007
Recent studies have highlighted the importance of paracrine growth factors as mediators of pro‐angiogenic effects by endothelial progenitor cells (EPCs), but little is known about the release of lipid‐based factors like endocannabinoids by EPCs. In the current study, the release of the endocannabinoids anandamide and 2‐arachidonoylglycerol by distinct ...
Opitz, Christiane A., Rimmerman, Neta, Zhang, Yanmin, Mead, Laura E., Yoder, Mervin C., Ingram, David A., Walker, J. Michael, Rehman, Jalees   +7 more
openaire   +2 more sources

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Journal of Neuroinflammation, 2018
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins ...
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad   +10 more
doaj   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

The uptake by cells of 2‐arachidonoylglycerol, an endogenous agonist of cannabinoid receptors [PDF]

European Journal of Biochemistry, 2001
It is not yet clear if the endocannabinoid 2‐arachidonoylglycerol (2‐AG) is transported into cells through the same membrane transporter mediating the uptake of the other endogenous cannabinoid, anandamide (N‐arachidonoylethanolamine, AEA), and whether this process (a) is regulated by cells and (b) limits 2‐AG pharmacological actions.
Bisogno T, Maccarrone M, De Petrocellis L, Jarrahian A, FinazziAgrò A, Hillard C, Di Marzo V   +6 more
openaire   +3 more sources

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

A Super‐Resolution Approach for Astrocyte‐Specific Molecular Imaging Reveals the Nanoscale Distribution of Monoacylglycerol Lipase, the Metabolic Node Between Endocannabinoid and Prostaglandin Signaling

Glia, Volume 74, Issue 9, September 2026.
Dual‐color STORM resolves the precise architecture and protein distributions within hippocampal astrocytes at the nanoscale. Identification of a sparse but specific MAGL pool in CA1 astrocytic processes. Astrocytic MAGL is not synapse‐associated, suggesting a synapse‐independent role.
Miklós Zöldi, István Katona
wiley   +1 more source

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +1 more source