Results 31 to 40 of about 17,658,570 (203)

Circulating endocannabinoid levels in pregnant women with gestational diabetes mellitus: a case–control study

BMC Endocrine Disorders, 2022
Background The role of the Endocannabinoids (ECs) in insulin resistance, and their association with visceral obesity and metabolic profile have been studied extensively.
Hadi Bazyar, Khadijeh Nasiri, Parisa Ghanbari, Elahe Mohammadi, Neda Lotfi Yagin, Maryam Khazdouz, Vahideh Aghamohammadi, Shafagh Ali Asgarzadeh   +7 more
doaj   +1 more source

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

Molecules, 2021
The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott, Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, Alana C. Conti   +4 more
doaj   +1 more source

Targeting 2‐arachidonoylglycerol signalling in the neurobiology and treatment of depression [PDF]

Basic & Clinical Pharmacology & Toxicology, 2021
AbstractThe endocannabinoid 2‐arachidonoylglycerol (2‐AG) is an atypical neurotransmitter synthesized on demand in response to a wide range of stimuli, including exposure to stress. Through the activation of cannabinoid receptors, 2‐AG can interfere with excitatory and inhibitory neurotransmission in different brain regions and modulate behavioural ...
Kennia M. Silveira, Gregers Wegener, Sâmia R. L. Joca   +2 more
openaire   +2 more sources

Deficiency in endocannabinoid synthase DAGLB contributes to early onset Parkinsonism and murine nigral dopaminergic neuron dysfunction

Nature Communications, 2022
2- arachidonoylglycerol (2-AG), an abundant endocannabinoid in the brain, regulates diverse neural functions. Here, the authors identified four loss-of-function mutations in dicylglycerol lipase β (DAGLB) from six patients with early onset Parkinsonism ...
Zhenhua Liu, Nannan Yang, Jie Dong, Wotu Tian, Lisa Chang, Jinghong Ma, Jifeng Guo, Jieqiong Tan, Ao Dong, Kaikai He, Jingheng Zhou, Resat Cinar, Junbing Wu, Armando G. Salinas, Lixin Sun, Mantosh Kumar, Breanna T. Sullivan, Braden B. Oldham, Vanessa Pitz, Mary B. Makarious, Jinhui Ding, Justin Kung, Chengsong Xie, Sarah L. Hawes, Lupeng Wang, Tao Wang, Piu Chan, Zhuohua Zhang, Weidong Le, Shengdi Chen, David M. Lovinger, Cornelis Blauwendraat, Andrew B. Singleton, Guohong Cui, Yulong Li, Huaibin Cai, Beisha Tang   +36 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +1 more source

Circulating Endocannabinoids as Diagnostic Markers of Canine Chronic Enteropathies: A Pilot Study

Frontiers in Veterinary Science, 2021
Chronic enteropathies (CEs) in dogs, according to the treatment response to consecutive trials, are classified as food-responsive (FRE), antibiotic-responsive (ARE), and immunosuppressive-responsive (IRE) enteropathy.
Elettra Febo, Paolo Emidio Crisi, Sergio Oddi, Sergio Oddi, Marco Pietra, Giorgia Galiazzo, Fabiana Piscitelli, Alessandro Gramenzi, Roberta Di Prinzio, Morena Di Tommaso, Nicola Bernabò, Nicola Bernabò, Tiziana Bisogno, Mauro Maccarrone, Mauro Maccarrone, Andrea Boari   +15 more
doaj   +1 more source

Circadian Rhythm of Circulating Levels of the Endocannabinoid 2-Arachidonoylglycerol [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2015
Abstract Context: The endocannabinoid (eCB) system is involved in the regulation of food intake and of peripheral metabolism. Although the cross talk between energy metabolism and the circadian system is well documented, little is known about a potential circadian modulation of human eCB activity.
Hanlon, Erin E.C., Tasali, Esra, Van Cauter, Eve, De Wit, H., Leproult, Rachel, Stuhr, Kara K.L., Doncheck, Elizabeth, Hillard, Cecilia C.J.   +7 more
openaire   +3 more sources

Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs[S]

Journal of Lipid Research, 2014
The analysis of peripheral endocannabinoids (ECs) is a good biomarker of the EC system. Their concentrations, from clinical studies, strongly depend on sample collection and time processing conditions taking place in clinical and laboratory settings. The
Antoni Pastor, Magí Farré, Montserrat Fitó, Fernando Fernandez-Aranda, Rafael de la Torre   +4 more
doaj   +1 more source

Hypothalamic 2-arachidonoylglycerol regulates multistage process of high-fat diet preferences. [PDF]

PLoS ONE, 2012
In this study, we examined alterations in the hypothalamic reward system related to high-fat diet (HFD) preferences. We previously reported that hypothalamic 2-arachidonoylglycerol (2-AG) and glial fibrillary acid protein (GFAP) were increased after ...
Sei Higuchi, Keiichi Irie, Ryuji Yamaguchi, Mai Katsuki, Maiko Araki, Makiko Ohji, Kazuhide Hayakawa, Shohei Mishima, Yoshiharu Akitake, Kiyoshi Matsuyama, Kenji Mishima, Kenichi Mishima, Katsunori Iwasaki, Michihiro Fujiwara   +13 more
doaj   +1 more source

A Methodology for Radiolabeling of the Endocannabinoid 2-Arachidonoylglycerol (2-AG) [PDF]

The Journal of Organic Chemistry, 2011
The metabolic intermediate and endocannabinoid signaling lipid 2-arachidonoylglycerol (2-AG) has not been readily labeled, primarily because of its instability toward rearrangement. We now detail a synthetic method that easily gives tritiated 2-AG from [5,6,8,9,11,12,14,15-(3)H(N)]arachidonic acid in two steps.
Richard I, Duclos, Meghan, Johnston, Subramanian K, Vadivel, Alexandros, Makriyannis, Sherrye T, Glaser, S John, Gatley   +5 more
openaire   +2 more sources