Results 31 to 40 of about 24,579,074 (168)

Circulating Endocannabinoids in Canine Multicentric Lymphoma Patients

Frontiers in Veterinary Science, 2022
The endocannabinoid system is increasingly being implicated in the pathogenesis and progression of various human cancers. Specifically, increased levels of 2-arachidonoylglycerol (2-AG) and oleoythanolamide (OEA) have been demonstrated in human diffuse ...
Jennifer K. Hay, Samuel E. Hocker, Samuel E. Hocker, Gabrielle Monteith, J. Paul Woods   +4 more
doaj   +1 more source

Placental DAGLβ regulates 2-arachidonoylglycerol (2-AG) levels and is involved in pregnancy induced inflammation

, 2021
Diacylglycerollipase alpha/beta (DAGLα/β) are two sequence-related serine hydrolases, biosynthesizing 2-arachidonoylglycerol (2-AG). 2-AG, one of the main endocannabinoids, and its esterified fatty acid arachidonic acid serve as substrates for pro ...
Bärnthaler, Thomas; orcid:, Girgis, Nermeen, Birner-Grünberger, Ruth; orcid:, Hirschmugl, Birgit, van der Wel, Tom; orcid:, Wadsack, Christian, Berger, Natascha, Gindlhuber, Juergen, Zimmermann, Robert, van der Stelt, Mario; orcid:   +9 more
core   +1 more source

Targeting Monoacylglycerol Lipase in Pursuit of Therapies for Neurological and Neurodegenerative Diseases

Molecules, 2021
Neurological and neurodegenerative diseases are debilitating conditions, and frequently lack an effective treatment. Monoacylglycerol lipase (MAGL) is a key enzyme involved in the metabolism of 2-AG (2-arachidonoylglycerol), a neuroprotective ...
Anca Zanfirescu, Anca Ungurianu, Dragos Paul Mihai, Denise Radulescu, George Mihai Nitulescu   +4 more
doaj   +1 more source

2-Arachidonoylglycerol, 1-arachidonoylglycerol and the stable 2-arachidonoylglycerol analog noladin ether activate native TRPV1.

, 2013
(A) Concentration-response curves for 2-arachidonoylglycerol (2-AG), 1-arachidonoylglycerol (1-AG) and noladin ether (NE) in the presence and absence of the TRPV1 antagonist capsazepine. Control experiments were performed in the presence of vehicle (0.1%
Peter M. Zygmunt (241661), Anna Ermund (241659), Bryndis Birnir (113570), Alain Eschalier (209750), Stuart Bevan (303154), Bo A. G. Jönsson (241660), Edward D. Högestätt (241662), Charlotte Simonsen (441655), Pouya Movahed (491625), Christophe Mallet (241657), David A. Andersson (303152), Ana Gomis (491626), Anders Blomgren (441654)   +12 more
core   +1 more source

Production of the endocannabinoids anandamide and 2-arachidonoylglycerol by endothelial progenitor cells [PDF]

, 2007
Recent studies have highlighted the importance of paracrine growth factors as mediators of pro-angiogenic effects by endothelial progenitor cells (EPCs), but little is known about the release of lipid-based factors like endocannabinoids by EPCs.
Mead, Laura E., Walker, J. Michael, Zhang, Yanmin, Rimmerman, Neta, Yoder, Mervin C., Ingram, David A., Rehman, Jalees, Opitz, Christiane A.   +7 more
core   +1 more source

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

Journal of Lipid Research, 2015
The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling ...
Tom van der Wel, Freek J. Janssen, Marc P. Baggelaar, Hui Deng, Hans den Dulk, Herman S. Overkleeft, Mario van der Stelt   +6 more
doaj   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Arterial concentrations of 2-arachidonoylglycerol.

, 2019
Panels A and B depict the same data of arterial concentrations of 2-AG [pmol/ml]. Data are presented as the mean ± standard error of the mean. For the purpose of clarity, values in panel (A) are grouped by extraction site, allowing for comparison of ...
Georg Nickenig (287655), Hanna Goerich (8201481), Vedat Tiyerili (4287751), Julian Jehle (586001), Laura Bindila (843199), Beat Lutz (24734)   +5 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways

British Journal of Pharmacology, EarlyView.
Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck, Mario van der Stelt   +1 more
wiley   +1 more source