Results 51 to 60 of about 17,658,570 (203)

Inverse correlation between plasma 2‐arachidonoylglycerol levels and subjective severity of depression

, 2021
Objective: Endocannabinoids have been implicated in the pathophysiology of Major Depressive Disorder (MDD) and might represent potential targets for therapeutic intervention.
Valentina Cuoco, Bowles, Nicole P., Francesca Pacitti, Fanelli, Flaminia, Dionysios Xenos, Michela Marconi, Nasca, Carla, Giuseppe Bersani, Carla Nasca, Di Lallo, Valentina D., Pacitti, Francesca, Flaminia Fanelli, Angela Iannitelli, Ilaria Belluomo, Nicoletti, Ferdinando, Bersani, Giuseppe, Caroti, Eleonora, Iannitelli, Angela, Nicole P. Bowles, Belluomo, Ilaria, Bigio, Benedetta, Cuoco, Valentina, Weisz, Filippo, Eleonora Caroti, Valentina D. Di Lallo, Benedetta Bigio, Ferdinando Nicoletti, Filippo Weisz, Marconi, Michela, Adele Quartini, Xenos, Dionysios, Quartini, Adele   +31 more
core   +2 more sources

Arterial concentrations of 2-arachidonoylglycerol.

, 2019
Panels A and B depict the same data of arterial concentrations of 2-AG [pmol/ml]. Data are presented as the mean ± standard error of the mean. For the purpose of clarity, values in panel (A) are grouped by extraction site, allowing for comparison of ...
Georg Nickenig (287655), Hanna Goerich (8201481), Vedat Tiyerili (4287751), Julian Jehle (586001), Laura Bindila (843199), Beat Lutz (24734)   +5 more
core   +1 more source

Inhibition of 2-AG hydrolysis differentially regulates blood brain barrier permeability after injury

Journal of Neuroinflammation, 2018
Background Acute neurological insults caused by infection, systemic inflammation, ischemia, or traumatic injury are often associated with breakdown of the blood-brain barrier (BBB) followed by infiltration of peripheral immune cells, cytotoxic proteins ...
Justin R. Piro, Georgette L. Suidan, Jie Quan, YeQing Pi, Sharon M. O’Neill, Marissa Ilardi, Nikolay Pozdnyakov, Thomas A. Lanz, Hualin Xi, Robert D. Bell, Tarek A. Samad   +10 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation

, 2011
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions for which new therapeutic approaches are needed. Genetic and pharmacological data point to a protective role of CB(1) and CB(2) cannabinoid receptor activation in IBD experimental ...
Delzenne, Nathalie M., Al Houayek, Mireille, Muccioli, Giulio, Patrice D. Cani, Mireille Alhouayek, Lambert, Didier, Cani, Patrice D., Nathalie M. Delzenne, Didier M. Lambert, Giulio G. Muccioli   +9 more
core   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

The uptake by cells of 2‐arachidonoylglycerol, an endogenous agonist of cannabinoid receptors [PDF]

European Journal of Biochemistry, 2001
It is not yet clear if the endocannabinoid 2‐arachidonoylglycerol (2‐AG) is transported into cells through the same membrane transporter mediating the uptake of the other endogenous cannabinoid, anandamide (N‐arachidonoylethanolamine, AEA), and whether this process (a) is regulated by cells and (b) limits 2‐AG pharmacological actions.
Bisogno T, Maccarrone M, De Petrocellis L, Jarrahian A, FinazziAgrò A, Hillard C, Di Marzo V   +6 more
openaire   +3 more sources

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source