Results 51 to 60 of about 24,579,074 (168)

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

A Methodology for Radiolabeling of the Endocannabinoid 2-Arachidonoylglycerol (2-AG)

, 2016
The metabolic intermediate and endocannabinoid signaling lipid 2-arachidonoylglycerol (2-AG) has not been readily labeled, primarily because of its instability toward rearrangement.
Alexandros Makriyannis (32548), Sherrye T. Glaser (479290), Subramanian K. Vadivel (309316), Meghan Johnston (2216059), S. John Gatley (1749211), Richard I. Duclos (1749199)   +5 more
core   +1 more source

Discrepancy in Reported and Observed Monoacylglycerol Lipase Inhibition of Aryl Formyl Piperidine Containing Potent and Highly Selective Monoacylglycerol Lipase Inhibitor

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A reported potent and selective reversible MAGL inhibitor fails to reproduce its claimed potency in two established in vitro assays, even when the previously reported substrate is used, while eight related analogs are likewise inactive. The findings highlight substantial assay‐dependent behavior and the need for careful validation before such compounds
Juha R. Savinainen, Praveen Kumar Singh, Jari Yli‐Kauhaluoma, Jayendra Z. Patel   +3 more
wiley   +1 more source

Distinct serum endocannabinoid profiles in treatment-naïve Han Chinese children with ADHD: a case–control pilot study

Frontiers in Neurology
ObjectiveAlthough peripheral endocannabinoid system (ECS) signatures have been implicated in ADHD among European and American populations, evidence from Asian pediatric cohorts remains scarce.
Wenjuan Liao, Xiaobin Tan, Jinhai Lin, Yuchen Wu, Qi Guo, Qucheng Huang, Longhe Yang, Yan Peng   +7 more
doaj   +1 more source

Krill oil significantly decreases 2-arachidonoylglycerol plasma levels in obese subjects

Nutrition & Metabolism, 2011
We have previously shown that krill oil (KO), more efficiently than fish oil, was able to downregulate the endocannabinoid system in different tissues of obese zucker rats.
Giordano Elena, Cordeddu Lina, Murru Elisabetta, Carta Gianfranca, Banni Sebastiano, Sirigu Anna, Berge Kjetil, Vik Hogne, Maki Kevin C, Di Marzo Vincenzo, Griinari Mikko   +10 more
doaj   +1 more source

Cannabinoid CB1 allosteric ligands suppress inflammatory pain in male mice without tolerance, motor impairment, memory deficits or respiratory depression

British Journal of Pharmacology, Volume 183, Issue 20, Page 6132-6153, October 2026.
Abstract Background and Purpose Positive allosteric modulators (PAMs) engage sites distinct from the orthosteric CB1 cannabinoid receptor binding site. GAT211, a racemic ligand, contains GAT228 (R) and GAT229 (S) enantiomers. Whether enantiomer‐mediated differences in allosteric activation or positive allosteric modulation translate into differences in
Ifeoluwa D. Solomon, Sumanta Garai, Ganesh A. Thakur, Andrea G. Hohmann   +3 more
wiley   +1 more source

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, Volume 13, Issue 53, 24 September 2026.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Placental DAGLbeta Regulates 2-arachidonoylglycerol Levels and Is Involved in Pregnancy Induced Inflammation

, 2021
Diacylglycerollipase alpha/beta (DAGLa/b) are two sequencerelated serine hydrolases, biosynthesizing 2-arachidonoylglycerol (2-AG). 2-AG, one of the main endocannabinoids, and its esterified fatty acid arachidonic acid serve as substrates for pro ...
Zimmermann, R., Hirschmugl, Birgit, Wadsack, Christian, Berger, Natascha, Gindlhuber, Juergen, Birner-Grünberger, Ruth   +5 more
core   +1 more source

Investigating the effect of enzymatic elimination of endocannabinoids inhibitors on tonic- colonic seizure provoked by PTZ

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: In recent years, numerous attempts were done to find new treatment methods for patients with drug-resistant epilepsy. Anandamide (Anandamides; AEA) and di-Arachidonoylglycerol (2-Arachidonoylglycerol; 2-AG) are two major ligands
P Zareie, M Sadegh, MR Palizvan
doaj  

Oxyradical Stress, Endocannabinoids, and Atherosclerosis

Toxics, 2015
Atherosclerosis is responsible for most cardiovascular disease (CVD) and is caused by several factors including hypertension, hypercholesterolemia, and chronic inflammation.
Anberitha T. Matthews, Matthew K. Ross
doaj   +1 more source