Benzylamides and piperazinoarylamides of ibuprofen as fatty acid amide hydrolase inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Fatty Acid Amide Hydrolase (FAAH) is a serine hydrolase that plays a key role in controlling endogenous levels of endocannabinoids. FAAH inhibition is considered a powerful approach to enhance the endocannabinoid signalling, and therefore it has been ...
Alessandro Deplano +6 more
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Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism [PDF]
Veterinary Sciences, 2022 Gastrointestinal (GI) dysmotility in diabetics exhibits fecal incontinence or constipation which affects patients’ quality of life. In this study, we aimed to understand the pattern of GI transit in type 1 diabetic (T1D) mice and whether inhibiting ...
Vikram Thakur +3 more
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Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation [PDF]
NeuroImage: Reports, 2022 Background: Preclinical evidence suggests that increasing levels of the major endocannabinoid anandamide decreases anxiety and fear responses potentially through its effects in the amygdala.
Duncan GJ. Green +8 more
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Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer [PDF]
Nature Communications, 2023 Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is ...
Isabel Tundidor +24 more
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Identification of quinolinyl-containing dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase [PDF]
Results in ChemistryUsing a polypharmacological approach, we designed two different quinolinyl libraries by merging the pharmacophores of three targeted enzymes, fatty acid amide hydrolase (FAAH), soluble epoxide hydrolase (sEH), and acetylcholinesterase (AChE).
Michael Gonzalez +5 more
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Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance [PDF]
MoleculesFatty acid amide hydrolase (FAAH) is a central component of the endocannabinoid system (ECS), where it primarily regulates intracellular levels of anandamide (AEA) through enzymatic hydrolysis.
Qinghe Lin +4 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Inhibition of fatty acid amide hydrolase (FAAH) reduces the gastrointestinal damage produced by non-steroidal anti-inflammatory agents such as sulindac and indomethacin in experimental animals, suggesting that a dual-action FAAH-cyclooxygenase (COX ...
Alessandro Deplano +6 more
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A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase
Molecular Pain, 2016 Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely ...
Lawrence M Carey BA, MS +6 more
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Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation [PDF]
Cell Death DiscoveryMammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by
Isabel Tundidor +9 more
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Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]
HeliyonSimultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia +11 more
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