Inhibiting Fatty Acid Amide Hydrolase Ameliorates Enteropathy in Diabetic Mice: A Cannabinoid 1 Receptor Mediated Mechanism [PDF]
Veterinary Sciences, 2022 Gastrointestinal (GI) dysmotility in diabetics exhibits fecal incontinence or constipation which affects patients’ quality of life. In this study, we aimed to understand the pattern of GI transit in type 1 diabetic (T1D) mice and whether inhibiting ...
Vikram Thakur +3 more
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Fatty acid amide hydrolase levels in brain linked with threat-related amygdala activation [PDF]
NeuroImage: Reports, 2022 Background: Preclinical evidence suggests that increasing levels of the major endocannabinoid anandamide decreases anxiety and fear responses potentially through its effects in the amygdala.
Duncan GJ. Green +8 more
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Identification of fatty acid amide hydrolase as a metastasis suppressor in breast cancer [PDF]
Nature Communications, 2023 Clinical management of breast cancer (BC) metastasis remains an unmet need as it accounts for 90% of BC-associated mortality. Although the luminal subtype, which represents >70% of BC cases, is generally associated with a favorable outcome, it is ...
Isabel Tundidor +24 more
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Identification of quinolinyl-containing dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors with moderate potency towards acetylcholinesterase [PDF]
Results in ChemistryUsing a polypharmacological approach, we designed two different quinolinyl libraries by merging the pharmacophores of three targeted enzymes, fatty acid amide hydrolase (FAAH), soluble epoxide hydrolase (sEH), and acetylcholinesterase (AChE).
Michael Gonzalez +5 more
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Fatty Acid Amide Hydrolase Signaling and Ovarian Disorders: From Molecular Mechanism to Clinical Significance [PDF]
MoleculesFatty acid amide hydrolase (FAAH) is a central component of the endocannabinoid system (ECS), where it primarily regulates intracellular levels of anandamide (AEA) through enzymatic hydrolysis.
Qinghe Lin +4 more
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Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation [PDF]
Cell Death DiscoveryMammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by
Isabel Tundidor +9 more
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Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]
HeliyonSimultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia +11 more
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New Disulfiram Derivatives as MAGL-Selective Inhibitors
Molecules, 2021 Monoacylglycerol lipase (MAGL) is a key enzyme in the human endocannabinoid system. It is also the main enzyme responsible for the conversion of 2-arachidonoyl glycerol (2-AG) to arachidonic acid (AA), a precursor of prostaglandin synthesis.
Ziad Omran
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Frontiers in Physiology, 2021 The endocannabinoid system is expressed in cells throughout the body and controls a variety of physiological and pathophysiological functions. We describe robust and reproducible UPLC-MS/MS-based methods for analyzing metabolism of the endocannabinoids ...
Mark B. Wiley +5 more
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Structural Model Based on Genetic Algorithm for Inhibiting Fatty Acid Amide Hydrolase
AI, 2022 The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field.
Cosmin Trif +3 more
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