Results 11 to 20 of about 11,683 (171)
Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]
HeliyonSimultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia +11 more
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New Disulfiram Derivatives as MAGL-Selective Inhibitors
Molecules, 2021 Monoacylglycerol lipase (MAGL) is a key enzyme in the human endocannabinoid system. It is also the main enzyme responsible for the conversion of 2-arachidonoyl glycerol (2-AG) to arachidonic acid (AA), a precursor of prostaglandin synthesis.
Ziad Omran
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Frontiers in Physiology, 2021 The endocannabinoid system is expressed in cells throughout the body and controls a variety of physiological and pathophysiological functions. We describe robust and reproducible UPLC-MS/MS-based methods for analyzing metabolism of the endocannabinoids ...
Mark B. Wiley +5 more
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Structural Model Based on Genetic Algorithm for Inhibiting Fatty Acid Amide Hydrolase
AI, 2022 The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field.
Cosmin Trif +3 more
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Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
eLife, 2020 The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 ...
Joon T Kim +5 more
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Journal of Lipid Research, 2012 The tissue-specific sources and regulated production of physiological signals that modulate food intake are incompletely understood. Previous work showed that L-Fabp−/− mice are protected against obesity and hepatic steatosis induced by a high-fat diet ...
Elizabeth P. Newberry +8 more
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Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease.
PLoS ONE, 2012 ObjectiveAlzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the ...
Claudio D'Addario +10 more
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Journal of Lipid Research, 2013 Percutaneous transluminal angioplasty is frequently used in patients with severe arterial narrowing due to atherosclerosis. However, it induces severe arterial injury and an inflammatory response leading to restenosis.
Filippo Molica +11 more
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Türk Biyokimya Dergisi, 2023 Given that drug addiction occurs as a result of complex gene-environment interaction, a number of studies claimed that cannabinoid receptor 1 (CNR1), fatty acid amide hydrolase (FAAH), and monoacylglycerol lipase (MGLL) single nucleotide polymorphisms ...
Altun Beril +8 more
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PLoS ONE, 2014 BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund +4 more
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