Results 11 to 20 of about 11,251 (174)
Fatty acid amide hydrolase is lower in young cannabis users. [PDF]
Addict Biol, 2021 AbstractWe have recently shown that levels of fatty acid amide hydrolase (FAAH), the enzyme that metabolizes the endocannabinoid anandamide, are lower in the brains of adult cannabis users (CUs) (34 ± 11 years of age), tested during early abstinence. Here, we examine replication of the lower FAAH levels in a separate, younger cohort (23 ± 5 years of ...
Jacobson MR +9 more
europepmc +4 more sources
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH) [PDF]
Bioorganic and Medicinal Chemistry Letters, 2011 A summary of the discovery and advancement of inhibitors of fatty acid amide hydrolase (FAAH) is presented.
Dale L Boger
exaly +3 more sources
Fatty acid amide hydrolase drives adult mammary gland development by promoting luminal cell differentiation [PDF]
Cell Death DiscoveryMammary gland development occurs primarily in adulthood, undergoing extensive expansion during puberty followed by cycles of functional specialization and regression with every round of pregnancy/lactation/involution. This process is ultimately driven by
Isabel Tundidor +9 more
doaj +2 more sources
Quinolinyl-based multitarget-directed ligands with soluble epoxide hydrolase and fatty acid amide hydrolase inhibitory activities: Synthetic studies and pharmacological evaluations [PDF]
HeliyonSimultaneous inhibition of soluble epoxide hydrolase (sEH) and fatty acid amide hydrolase (FAAH) with a single small molecule represents a novel therapeutic approach in treating inflammatory pain, since both targets are involved in pain and inflammation ...
Jeannes Angelia +11 more
doaj +2 more sources
New Disulfiram Derivatives as MAGL-Selective Inhibitors
Molecules, 2021 Monoacylglycerol lipase (MAGL) is a key enzyme in the human endocannabinoid system. It is also the main enzyme responsible for the conversion of 2-arachidonoyl glycerol (2-AG) to arachidonic acid (AA), a precursor of prostaglandin synthesis.
Ziad Omran
doaj +1 more source
Frontiers in Physiology, 2021 The endocannabinoid system is expressed in cells throughout the body and controls a variety of physiological and pathophysiological functions. We describe robust and reproducible UPLC-MS/MS-based methods for analyzing metabolism of the endocannabinoids ...
Mark B. Wiley +5 more
doaj +1 more source
Structural Model Based on Genetic Algorithm for Inhibiting Fatty Acid Amide Hydrolase
AI, 2022 The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field.
Cosmin Trif +3 more
doaj +1 more source
Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH
eLife, 2020 The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 ...
Joon T Kim +5 more
doaj +1 more source
Journal of Lipid Research, 2012 The tissue-specific sources and regulated production of physiological signals that modulate food intake are incompletely understood. Previous work showed that L-Fabp−/− mice are protected against obesity and hepatic steatosis induced by a high-fat diet ...
Elizabeth P. Newberry +8 more
doaj +1 more source
Journal of Lipid Research, 2013 Percutaneous transluminal angioplasty is frequently used in patients with severe arterial narrowing due to atherosclerosis. However, it induces severe arterial injury and an inflammatory response leading to restenosis.
Filippo Molica +11 more
doaj +1 more source