Results 31 to 40 of about 20,213 (210)

Structural Model Based on Genetic Algorithm for Inhibiting Fatty Acid Amide Hydrolase

AI, 2022
The fatty acid amide hydrolase (FAAH) is an enzyme responsible for the degradation of anandamide, an endocannabinoid. Pharmacologically blocking this target can lead to anxiolytic effects; therefore, new inhibitors can improve therapy in this field.
Cosmin Trif, Dragos Paul Mihai, Anca Zanfirescu, George Mihai Nitulescu   +3 more
doaj   +1 more source

Elevated Anandamide, Enhanced Recall of Fear Extinction, and Attenuated Stress Responses Following Inhibition of Fatty Acid Amide Hydrolase: A Randomized, Controlled Experimental Medicine Trial.

Biological Psychiatry, 2020
BACKGROUND Posttraumatic stress disorder, an area of large unmet medical needs, is characterized by persistence of fear memories and maladaptive stress responses.
L. Mayo, A. Asratian, Johan Lindé, M. Morena, Roosa Haataja, Valter Hammar, Gaëlle Augier, Matthew N Hill, M. Heilig   +8 more
semanticscholar   +1 more source

Elevated Brain Fatty Acid Amide Hydrolase Induces Depressive-Like Phenotypes in Rodent Models: A Review

International Journal of Molecular Sciences, 2021
Altered activity of fatty acid amide hydrolase (FAAH), an enzyme of the endocannabinoid system, has been implicated in several neuropsychiatric disorders, including major depressive disorder (MDD). It is speculated that increased brain FAAH expression is
Dorsa Rafiei, N. Kolla
semanticscholar   +1 more source

Cooperative enzymatic control of N-acyl amino acids by PM20D1 and FAAH

eLife, 2020
The N-acyl amino acids are a family of bioactive lipids with pleiotropic physiologic functions, including in energy homeostasis. Their endogenous levels are regulated by an extracellular mammalian N-acyl amino acid synthase/hydrolase called PM20D1 ...
Joon T Kim, Stephanie M Terrell, Veronica L Li, Wei Wei, Curt R Fischer, Jonathan Z Long   +5 more
doaj   +1 more source

The effects of inhibition of fatty acid amide hydrolase (FAAH) by JNJ-42165279 in social anxiety disorder: a double-blind, randomized, placebo-controlled proof-of-concept study

Neuropsychopharmacology, 2020
JNJ-42165279 is a selective inhibitor of fatty acid amide hydrolase (FAAH), the enzyme responsible for the degradation of fatty acid amides (FAA) including anandamide (AEA), palmitoylethanolamide (PEA), and N-oleoylethanolamide (OEA).
M. Schmidt, M. Liebowitz, M. Stein, Jennifer Grunfeld, Ilse van Hove, W. K. Simmons, P. D. van der Ark, J. Palmer, Ziad S. Saad, D. Pemberton, L. van Nueten, W. Drevets   +11 more
semanticscholar   +1 more source

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents.

ACS Chemical Neuroscience, 2021
Temporal lobe epilepsy is the most common form of epilepsy, and current antiepileptic drugs are ineffective in many patients. The endocannabinoid system has been associated with an on-demand protective response to seizures.
Alessandro Grillo, F. Fezza, Giulia Chemi, R. Colangeli, Simone Brogi, Domenico Fazio, Stefano Federico, Alessandro Papa, Nicola Relitti, R. Di Maio, G. Giorgi, S. Lamponi, M. Valoti, B. Gorelli, S. Saponara, M. Benedusi, A. Pecorelli, P. Minetti, G. Valacchi, S. Butini, G. Campiani, S. Gemma, M. Maccarrone, G. Di Giovanni   +23 more
semanticscholar   +1 more source

Decreased body weight and hepatic steatosis with altered fatty acid ethanolamide metabolism in aged L-Fabp −/− mice

Journal of Lipid Research, 2012
The tissue-specific sources and regulated production of physiological signals that modulate food intake are incompletely understood. Previous work showed that L-Fabp−/− mice are protected against obesity and hepatic steatosis induced by a high-fat diet ...
Elizabeth P. Newberry, Susan M. Kennedy, Yan Xie, Jianyang Luo, Rosanne M. Crooke, Mark J. Graham, Jin Fu, Daniele Piomelli, Nicholas O. Davidson   +8 more
doaj   +1 more source

N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors.

Biological Psychiatry, 2020
BACKGROUND N6-methyladenosine (m6A) is the most abundant epigenetic modification in eukaryotic messenger RNAs and is essential for multiple RNA processing events in physiological and pathological processes.
Rongrong Huang, Yuan Zhang, Ying Bai, B. Han, Minzi Ju, Biling Chen, Li Yang, Yu Wang, Hongxing Zhang, Haisan Zhang, C. Xie, Zhijun Zhang, Honghong Yao   +12 more
semanticscholar   +1 more source

Epigenetic regulation of fatty acid amide hydrolase in Alzheimer disease.

PLoS ONE, 2012
ObjectiveAlzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the ...
Claudio D'Addario, Andrea Di Francesco, Beatrice Arosio, Cristina Gussago, Bernardo Dell'Osso, Monica Bari, Daniela Galimberti, Elio Scarpini, A Carlo Altamura, Daniela Mari, Mauro Maccarrone   +10 more
doaj   +1 more source

Endogenous cannabinoid receptor CB1 activation promotes vascular smooth-muscle cell proliferation and neointima formation

Journal of Lipid Research, 2013
Percutaneous transluminal angioplasty is frequently used in patients with severe arterial narrowing due to atherosclerosis. However, it induces severe arterial injury and an inflammatory response leading to restenosis.
Filippo Molica, Fabienne Burger, Aurélien Thomas, Christian Staub, Anne Tailleux, Bart Staels, Graziano Pelli, Andreas Zimmer, Benjamin Cravatt, Christian M. Matter, Pal Pacher, Sabine Steffens   +11 more
doaj   +1 more source