Results 31 to 40 of about 22,778 (210)

Involvement of fatty acid amide hydrolase and fatty acid binding protein 5 in the uptake of anandamide by cell lines with different levels of fatty acid amide hydrolase expression: a pharmacological study.

PLoS ONE, 2014
BackgroundThe endocannabinoid ligand anandamide (AEA) is removed from the extracellular space by a process of cellular uptake followed by metabolism. In many cells, such as the RBL-2H3 cell line, inhibition of FAAH activity reduces the observed uptake ...
Emmelie Björklund, Anders Blomqvist, Joel Hedlin, Emma Persson, Christopher J Fowler   +4 more
doaj   +1 more source

Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro

BMC Pharmacology and Toxicology, 2022
Background Pain relief remains a major subject of inadequately met need of patients. Therapeutic agents designed to treat pain and inflammation so far have low to moderate efficiencies with significant untoward side effects. FAAH-1 has been proposed as a
Julius T. Dongdem, Gideon K. Helegbe, Kwame Opare-Asamoah, Cletus A. Wezena, Augustine Ocloo   +4 more
doaj   +1 more source

Endocannabinoid-related compounds in gastrointestinal diseases [PDF]

, 2018
The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro, Esposito, Giuseppe, Gigli, Stefano, Giovanni, Sarnelli, Marcella, Pesce, Osvaldo, Borrelli, Rosario, Cuomo, Seguella, Luisa   +7 more
core   +1 more source

Inhibitory properties of ibuprofen and its amide analogues towards the hydrolysis and cyclooxygenation of the endocannabinoid anandamide [PDF]

, 2013
A dual-action cyclooxygenase (COX)–fatty acid amide hydrolase (FAAH) inhibitor may have therapeutic usefulness as an analgesic, but a key issue is finding the right balance of inhibitory effects.
Björklund E, CONGIU, CENZO, Fowler CJ, Lichtman AH, Naidu PS, ONNIS, VALENTINA   +5 more
core   +1 more source

Discovery of Uracil Derivatives as Potent Inhibitors of Fatty Acid Amide Hydrolase

Molecules, 2016
Fatty Acid Amide Hydrolase (FAAH) is an intracellular serine enzyme involved in the biological degradation of the fatty acid ethanolamide family of signaling lipids, which exerts neuroprotective, anti-inflammatory, and analgesic properties.
Yan Qiu, Yang Zhang, Yuhang Li, Jie Ren
doaj   +1 more source

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Campolongo, P., Chouker, A., Hauer, D., Huge, V., Kaufmann, I., Schelling, G., Thiel, M., Vogeser, M.   +7 more
core   +1 more source

Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana

Frontiers in Plant Science, 2012
N-Acylethanolamines (NAEs) are bioactive lipids derived from the hydrolysis of the membrane phospholipid N-acylphosphatidylethanolamine (NAPE). In animal systems this reaction is part of the endocannabinoid signaling pathway, which regulates a variety of
Neal D. Teaster, Jantana eKeereetaweep, Aruna eKilaru, Yuh-Shuh eWang, Yuhong eTang, Christopher N-Q Tran, Brian G. Ayre, Kent D. Chapman, Elison B. Blancaflor   +8 more
doaj   +1 more source

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity through network pharmacology and in-vitro cell-based assay

Heliyon
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chemical
Jasmeet Kaur, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda   +3 more
doaj   +1 more source

Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients

Biomolecules, 2021
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strategies for AD ...
Valerio Chiurchiù, Lucia Scipioni, Beatrice Arosio, Daniela Mari, Sergio Oddi, Mauro Maccarrone   +5 more
doaj   +1 more source

The ethanolamide metabolite of DHA, docosahexaenoylethanolamine, shows immunomodulating effects in mouse peritoneal and RAW264.7 macrophages: evidence for a new link between fish oil and inflammation [PDF]

, 2011
Several mechanisms have been proposed for the positive health effects associated with dietary consumption of long-chain n-3 PUFA (n-3 LC-PUFA) including DHA (22 : 6n-3) and EPA (20 : 5n-3).
Attya, M., Balvers, M.G.J., Gabriele, B., Gruppen, H., Meijerink, J., Plastina, P., Poland, M.C.R., Vincken, J.P., Witkamp, R.F.   +8 more
core   +3 more sources