Results 31 to 40 of about 13,359 (214)

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Storr, Martin, Huber, Erasmus, Azad, Shahnaz C., Schelling, Gustav, Vogeser, Michael, Hauer, Daniela   +5 more
core   +1 more source

Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana

Frontiers in Plant Science, 2012
N-Acylethanolamines (NAEs) are bioactive lipids derived from the hydrolysis of the membrane phospholipid N-acylphosphatidylethanolamine (NAPE). In animal systems this reaction is part of the endocannabinoid signaling pathway, which regulates a variety of
Neal D. Teaster, Jantana eKeereetaweep, Aruna eKilaru, Yuh-Shuh eWang, Yuhong eTang, Christopher N-Q Tran, Brian G. Ayre, Kent D. Chapman, Elison B. Blancaflor   +8 more
doaj   +1 more source

Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase [PDF]

Journal of Medicinal Chemistry, 2012
Sulfonyl fluorides are known to inhibit esterases. Early work from our laboratory has identified hexadecyl sulfonylfluoride (AM374) as a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH). We now report on later generation sulfonyl fluoride analogs that exhibit potent and selective inhibition of FAAH.
Shakiru O, Alapafuja, Spyros P, Nikas, Indu T, Bharathan, Vidyanand G, Shukla, Mahmoud L, Nasr, Anna L, Bowman, Nikolai, Zvonok, Jing, Li, Xiaomeng, Shi, John R, Engen, Alexandros, Makriyannis   +10 more
openaire   +2 more sources

Predicting the bioactive compounds of Lentinula edodes and elucidating its interaction with genes associated to obesity through network pharmacology and in-vitro cell-based assay

Heliyon
Mushrooms are traditionally used for various medicinal purposes in traditional oriental medicine. The Japanese and Chinese are familiar with the medicinal macro fungus Lentinula edodes (Shiitake mushroom). This study aims to evaluate the role of chemical
Jasmeet Kaur, Humaira Farooqi, Kailash Chandra, Bibhu Prasad Panda   +3 more
doaj   +1 more source

Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients

Biomolecules, 2021
Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strategies for AD ...
Valerio Chiurchiù, Lucia Scipioni, Beatrice Arosio, Daniela Mari, Sergio Oddi, Mauro Maccarrone   +5 more
doaj   +1 more source

Synthesis of Phenoxyacyl-Ethanolamides and Their Effects on Fatty Acid Amide Hydrolase Activity [PDF]

, 2014
This article discusses the synthesis of two sets of phenoxyacyl-ethanolamides from natural products, 3-n-pentadecylphenolethanolamide and cardanolethanolamide, with structural similarity to N-Acylethanolamines and characterizes their effects on the ...
Faure, Lionel, Blancaflor, Elison B., Koulen, Peter, Khan, Bibi Rafeiza, Nagarajan, Subbiah, Montgomery, Christa L., John, George, Hwang, Hyeondo, Chapman, Kent D.   +8 more
core   +1 more source

Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study[S]

Journal of Lipid Research, 2011
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed C57BL/6 mice using a targeted lipidomic approach.
Robin D. Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J. Yuen, Rajasekhar Ramakrishnan, Michael J. Lewis, Max E. Gottesman, Li-Shin Huang, Ira J. Goldberg, Paul D. Berk, William S. Blaner   +11 more
doaj   +1 more source

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

PLoS ONE, 2015
BackgroundIncreased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler   +8 more
doaj   +1 more source

The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders

Frontiers in Behavioral Neuroscience, 2018
Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including ...
Nathan J. Kolla, Nathan J. Kolla, Nathan J. Kolla, Achal Mishra, Achal Mishra   +4 more
doaj   +1 more source

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Journal of Lipid Research, 2020
N-acylethanolamines (NAEs) are endogenous lipid-signaling molecules derived from fatty acids that regulate numerous biological functions, including in the brain.
Lin Lin, Adam H. Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet   +8 more
doaj   +1 more source