Results 51 to 60 of about 22,778 (210)

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Cells, 2022
Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools suitable for the treatment of complex diseases, such as metabolic syndrome, psychiatric or degenerative
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi   +7 more
doaj   +1 more source

Effects of endocannabinoid system modulation on cognitive and emotional behavior [PDF]

, 2011
Cannabis has long been known to produce cognitive and emotional effects. Research has shown that cannabinoid drugs produce these effects by driving the brain's endogenous cannabinoid system and that this system plays a modulatory role in many cognitive ...
Claudio eZanettini, Leigh V. Panlilio, Manó eAliczki, Steven R. Goldberg, Jozsef eHaller, Sevil eYasar   +5 more
core   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

Advanced Science, EarlyView.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu, Bayinqiaoge, Xi Lu, Xin Wang, Rongfeng Wang, Yi Li, Shi‐Yang Tang, Chengchen Zhang   +7 more
wiley   +1 more source

Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as Neural Signaling Molecules [PDF]

, 2008
The definitive version is available at www3.interscience.wiley ...
Cravatt, BF, Egertova, M, Elphick, MR, Simon, GM   +3 more
core  

Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. [PDF]

, 2007
Recent studies have uncovered important cross talk between inflammation, generation of reactive oxygen and nitrogen species, and lipid metabolism in the pathogenesis of cardiovascular aging.
Bátkai, S., Cravatt, B.F., Csiszár, A., Haskó, G., Liaudet, L., Mukhopadhyay, P., Pacher, P., Rajesh, M., Ungvári, Z.   +8 more
core   +1 more source

Effect of inhibition of fatty acid amide hydrolase on MPTP-induced dopaminergic neuronal damage

Neurología (English Edition), 2019
Introduction: Parkinson's disease is a neurodegenerative disorder characterised by balance problems, muscle rigidity, and slow movement due to low dopamine levels and loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc).
J.M. Viveros-Paredes, R.E. Gonzalez-Castañeda, A. Escalante-Castañeda, A.R. Tejeda-Martínez, F. Castañeda-Achutiguí, M.E. Flores-Soto   +5 more
doaj   +1 more source

From Fertilisation to Implantation in Mammalian Pregnancy-Modulation of Early Human Reproduction by the Endocannabinoid System. [PDF]

, 2010
There is an increasing recognition that the endocannabinoid system is the crucial cytokine-hormone system regulating early human pregnancy. The synchronous development of the fertilized embryo and the endometrium to ensure timely implantation has been ...
Abel, Alger, Alpha Gebeh, Anthony H. Taylor, Aquila, Aquila, Aquila, Arnone, Barrett, Battista, Battista, Bisogno, Blankman, Bray, Bray, Carreau, Chabbert Buffet, Chmurzynska, Cobellis, Devane, Devane, Di Marzo, Di Marzo, Di Marzo, Dinh, El-Talatini, El-Talatini, Evers, Fonseca, Francavilla, Furuhashi, Geber, Gervasi, Godlewski, Gong, Grimaldi, Guo, Guzeloglu-Kayisli, Habayeb, Habayeb, Habayeb, Habayeb, Helliwell, Horne, Idris, Jonathon M. Willets, Justin C. Konje, Kaczocha, Katerina N. Bambang, Kim, Lambert, Larqué, Leung, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maccarrone, Maingret, Matsuda, Mechoulam, Mechoulam, Meizel, Muccioli, Munro, Newton, Nixon, O'Sullivan, Okamoto, Pan, Pandey, Paria, Paria, Paria, Paria, Paria, Park, Patricia Lam, Pestonjamasp, Piccini, Pierantoni, Ravinet Trillou, Regan, Rodriguez de Fonseca, Rodriguez de Fonseca, Ross, Rossato, Rossi, Schmid, Schuel, Schuel, Schuel, Schuel, Simiand, Sipe, Smith, Sofikitis, Sriraman, Sun, Tapia, Taylor, Taylor, Timothy H. Marczylo, Toth, Trabucco, Tsuboi, Tulay Karasu, Turco, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wei, Wenger, Wenger, Yamano, Yang   +125 more
core   +2 more sources

Depolymerization and Reuse of Polycarbonates: Emerging Classes, Mechanisms and Challenges

Angewandte Chemie, Volume 138, Issue 19, 4 May 2026.
This review collects the latest developments in the area of chemical and catalytic polycarbonate recycling strategies and includes the controlled degradation of similar types of macromolecules. Apart from the main strategies for deconstruction, the key mechanistic features of these depolymerization processes are also discussed together with the ...
Davide Rigo, David H. Lamparelli, Antonio Buonerba, Carmine Capacchione, Arjan W. Kleij   +4 more
wiley   +2 more sources

Role of cannabinoids in gastrointestinal mucosal defense and inflammation. [PDF]

, 2016
Modulating the activity of the endocannabinoid system influences various gastrointestinal physiological and pathophysiological processes, and cannabinoid receptors as well as regulatory enzymes responsible for the synthesis or degradation of ...
Gyires Klára, Zádori Zoltán Sándor
core   +2 more sources

Cannabidiol in Anorexia Nervosa: A Double‐Blind Randomized Placebo Controlled Pilot Study to Test Safety, Pharmacokinetics, and Symptom Change

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder marked by an intense fear of gaining weight and persistent body dissatisfaction, both during periods of underweight and after weight restoration. The endocannabinoid system may offer therapeutic benefits, particularly in reducing anxiety.
Neha Sahota, David J. Grelotti, Tyler Nguyen, Walter H. Kaye, Skylar Swindle, Raymond Suhandynata, Spencer Seely, Megan E. Shott, Guido K. W. Frank   +8 more
wiley   +1 more source