Results 51 to 60 of about 20,213 (210)

Overexpression of fatty acid amide hydrolase induces early flowering in Arabidopsis thaliana

Frontiers in Plant Science, 2012
N-Acylethanolamines (NAEs) are bioactive lipids derived from the hydrolysis of the membrane phospholipid N-acylphosphatidylethanolamine (NAPE). In animal systems this reaction is part of the endocannabinoid signaling pathway, which regulates a variety of
Neal D. Teaster, Jantana eKeereetaweep, Aruna eKilaru, Yuh-Shuh eWang, Yuhong eTang, Christopher N-Q Tran, Brian G. Ayre, Kent D. Chapman, Elison B. Blancaflor   +8 more
doaj   +1 more source

Imaging brain fatty acid amide hydrolase in untreated patients with psychosis

Biological Psychiatry, 2020
Background: The brain’s endocannabinoid system, the primary target of cannabis, has been implicated in psychosis. The endocannabinoid, anandamide, is elevated in cerebrospinal fluid of patients with schizophrenia.
Jeremy J. Watts, Maya R. Jacobson, Nittha Lalang, I. Boileau, R. Tyndale, M. Kiang, R. Ross, S. Houle, Alan A. Wilson, P. Rusjan, R. Mizrahi   +10 more
semanticscholar   +1 more source

Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice

British Journal of Pharmacology, 2020
Fatty acid amide hydrolase (FAAH) is an intracellular serine amidase that terminates the signalling of various lipid messengers involved in pain regulation, including anandamide and palmitoylethanolamide.
Yannick Fotio, F. Palese, Pablo Guaman Tipan, Faizy Ahmed, D. Piomelli   +4 more
semanticscholar   +1 more source

Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling

EMBO Molecular Medicine, 2020
Acid sphingomyelinase deficiency (ASMD) leads to cellular accumulation of sphingomyelin (SM), neurodegeneration, and early death. Here, we describe the downregulation of the endocannabinoid (eCB) system in neurons of ASM knockout (ASM‐KO) mice and a ASMD
A. Bartoll, Ana Toledano-Zaragoza, J. Casas, M. Guzmán, E. Schuchman, M. Ledesma   +5 more
semanticscholar   +1 more source

Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor.

PLoS ONE, 2015
BackgroundIncreased endocannabinoid tonus by dual-action fatty acid amide hydrolase (FAAH) and substrate selective cyclooxygenase (COX-2) inhibitors is a promising approach for pain-relief. One such compound with this profile is 2-(2-fluorobiphenyl-4-yl)-
Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler   +8 more
doaj   +1 more source

Altered hepatic lipid metabolism in C57BL/6 mice fed alcohol: a targeted lipidomic and gene expression study[S]

Journal of Lipid Research, 2011
Chronic alcohol consumption is associated with fatty liver disease in mammals. The object of this study was to gain an understanding of dysregulated lipid metabolism in alcohol-fed C57BL/6 mice using a targeted lipidomic approach.
Robin D. Clugston, Hongfeng Jiang, Man Xia Lee, Roseann Piantedosi, Jason J. Yuen, Rajasekhar Ramakrishnan, Michael J. Lewis, Max E. Gottesman, Li-Shin Huang, Ira J. Goldberg, Paul D. Berk, William S. Blaner   +11 more
doaj   +1 more source

Tetracosahexaenoylethanolamide, a novel N-acylethanolamide, is elevated in ischemia and increases neuronal output

Journal of Lipid Research, 2020
N-acylethanolamines (NAEs) are endogenous lipid-signaling molecules derived from fatty acids that regulate numerous biological functions, including in the brain.
Lin Lin, Adam H. Metherel, Mathieu Di Miceli, Zhen Liu, Cigdem Sahin, Xavier Fioramonti, Carolyn L. Cummins, Sophie Layé, Richard P. Bazinet   +8 more
doaj   +1 more source

The Endocannabinoid System, Aggression, and the Violence of Synthetic Cannabinoid Use, Borderline Personality Disorder, Antisocial Personality Disorder, and Other Psychiatric Disorders

Frontiers in Behavioral Neuroscience, 2018
Endogenous and exogenous cannabinoids bind to central cannabinoid receptors to control a multitude of behavioral functions, including aggression. The first main objective of this review is to dissect components of the endocannabinoid system, including ...
Nathan J. Kolla, Nathan J. Kolla, Nathan J. Kolla, Achal Mishra, Achal Mishra   +4 more
doaj   +1 more source

Polypharmacological Approaches for CNS Diseases: Focus on Endocannabinoid Degradation Inhibition

Cells, 2022
Polypharmacology breaks up the classical paradigm of “one-drug, one target, one disease” electing multitarget compounds as potential therapeutic tools suitable for the treatment of complex diseases, such as metabolic syndrome, psychiatric or degenerative
Alessandro Papa, Silvia Pasquini, Chiara Contri, Sandra Gemma, Giuseppe Campiani, Stefania Butini, Katia Varani, Fabrizio Vincenzi   +7 more
doaj   +1 more source

High Tree Species Diversity Promotes Thermal Enhancement Response of Microbial Carbon Use Efficiency

Advanced Science, EarlyView.
ABSTRACT Predicting soil carbon dynamics under warming is constrained by limited understanding of microbial thermal adaptation, particularly whether microbial carbon use efficiency (CUE) can adapt to warming and how plant diversity modulates this response. Using soils from a natural tree species diversity gradient in a subtropical forest, we combined a
Pengpeng Duan, Changqing Ye, Xinyi Yang, Chaoqun Wang, Wolfgang Wanek, Jian‐sheng Ye, Hongzhao Yuan, Hu Du, Kongcao Xiao, Xunyang He, Kelin Wang, Dejun Li   +11 more
wiley   +1 more source