Results 71 to 80 of about 13,359 (214)

Advancements in Mass Spectrometry‐Based Glycomics in Food and Nutritional Science

Mass Spectrometry Reviews, Volume 45, Issue 4, Page 829-850, July/August 2026.
ABSTRACT This review highlights advancements in mass spectrometry (MS)‐based glycomics in food and nutritional science. Carbohydrates, which are vital for human health, exhibit complex structures, making their analysis challenging. MS has become an indispensable tool for elucidating the structures of carbohydrates, including glycans, through soft ...
JaeHui Song, HyunJi Lee, Youngshik Choe, Hyeyoung Lee   +3 more
wiley   +1 more source

Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase [PDF]

Journal of Medicinal Chemistry, 2008
A series of alpha-ketooxazoles containing conformational constraints in the flexible C2 acyl side chain of 2 (OL-135) and representative oxazole C5 substituents were prepared and examined as inhibitors of fatty acid amide hydrolase (FAAH). Exceptionally potent and selective FAAH inhibitors emerged from the series (e.g., 6, Ki = 200 and 260 pM for rat ...
F Scott, Kimball, F Anthony, Romero, Cyrine, Ezzili, Joie, Garfunkle, Thomas J, Rayl, Dustin G, Hochstatter, Inkyu, Hwang, Dale L, Boger   +7 more
openaire   +2 more sources

Fatty acid amide hydrolase, anandamide, and neurological diseases

, 2023
The endocannabinoid anandamide (N-arachidonoylethanolamine, AEA) is a bioactive lipid that has been shown to regulate a number of important pathophysiological conditions in humans, including several neurological disorders.
De Sciscio M. L., Maccarrone M., Fezza F., Criscuolo E.   +3 more
core   +2 more sources

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase [PDF]

British Journal of Pharmacology, 2010
Background and purpose: Inhibitors of fatty acid amide hydrolase (FAAH), the enzyme responsible for the metabolism of the endogenous cannabinoid (CB) receptor ligand anandamide (AEA), are effective in a number of animal models of pain. Here, we investigated a series of isoflavones with respect to their abilities to inhibit FAAH.Experimental approach ...
L, Thors, J J, Burston, B J, Alter, M K, McKinney, B F, Cravatt, R A, Ross, R G, Pertwee, R W, Gereau, J L, Wiley, C J, Fowler   +9 more
openaire   +2 more sources

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease

, 2016
Elements of the endocannabinoid system are strongly expressed in the basal ganglia where they suffer profound rearrangements after dopamine depletion. Modulation of the levels of the endocannabinoid 2-arachidonoyl-glycerol by inhibiting monoacylglycerol ...
Fernández Suárez, Diana, Ramírez, María-José, Maldonado, Rafael, 1961-, Echeverry Alzate, Víctor, López Moreno, José A., Rojo Bustamante, Estefanía, Aymerich, María S., Hillard, Cecilia J., Oyarzábal, Julen, Celorrio, Marta, Franco, Rafael   +10 more
core   +1 more source

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]

Journal of Lipid Research, 2011
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long, Melanie LaCava, Xin Jin, Benjamin F. Cravatt   +3 more
doaj   +1 more source

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +1 more source

Lipopolysaccharide-induced pulmonary inflammation is not accompanied by a release of anandamide into the lavage fluid or a down-regulation of the activity of fatty acid amide hydrolase

, 2004
The effect of lipopolysaccharide inhalation upon lung anandamide levels, anandamide synthetic enzymes and fatty acid amide hydrolase has been investigated. Lipopolysaccharide exposure produced a dramatic extravasation of neutrophils and release of tumour
Di Marzo, Vincenzo, J. Fowler, C., Holt, Sandra,, Rocksén, D., Rocksén, David, Valenti, M., Valenti, Marta, Hansen, Harald S, Fowler, Christopher J,, Holt, S., Hansen, Harald S., Petersen, G., Bucht, A., Bucht, Anders, Petersen, Gitte, Di Marzo, V.   +15 more
core   +1 more source

Regulation of Inflammatory Pain by Inhibition of Fatty Acid Amide Hydrolase [PDF]

The Journal of Pharmacology and Experimental Therapeutics, 2010
Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for their therapeutic development. Conversely, fatty acid amide hydrolase (FAAH), the chief catabolic enzyme regulating the endogenous cannabinoid N-arachidonoylethanolamine (anandamide), has emerged as an
Pattipati S, Naidu, Steven G, Kinsey, Tai L, Guo, Benjamin F, Cravatt, Aron H, Lichtman   +4 more
openaire   +2 more sources