Results 81 to 90 of about 20,213 (210)

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]

Journal of Lipid Research, 2011
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long, Melanie LaCava, Xin Jin, Benjamin F. Cravatt   +3 more
doaj   +1 more source

Anti-Inflammatory Effects by Pharmacological Inhibition or Knockdown of Fatty Acid Amide Hydrolase in BV2 Microglial Cells

Cells, 2019
Fatty acid amide hydrolase (FAAH) has been recognized as a therapeutic target for several neurological diseases because its inhibition can exert neuroprotective and anti-inflammatory effects by boosting the endogenous levels of N-acylethanolamines ...
Mikiei Tanaka, Kazuya Yagyu, Scott Sackett, Yumin Zhang   +3 more
semanticscholar   +1 more source

Myocardial Lipid Metabolism Imbalance: The Pathological Core and Novel Diagnostic‐Therapeutic Directions of Cardiovascular Diseases

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 8, August 2026.
In cardiac cells, Plin5/AMPK regulate lipid homeostasis; excess CD36‐mediated uptake drives lipotoxicity, mitochondrial dysfunction, and CVDs (e.g., heart failure). Biomarkers (ApoB/ApoA‐1) and therapies (SGLT2 inhibitors) target this cascade. ABSTRACT Cardiac lipid metabolism is fundamental to myocardial energy homeostasis, with fatty acid oxidation ...
Peiyun Xie, Qun Zeng, Hongrui Wang, Meihua She   +3 more
wiley   +1 more source

A case series of the dynamics of lipid mediators in patients with sepsis

Acute Medicine & Surgery, 2019
Background Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.
Mitsuhide Hamaguchi, Heng Ning Wu, Masahiro Tanaka, Noriko Tsuda, Ourlad Alzeus Gaddi Tantengco, Tomohide Matsushima, Takami Nakao, Takuya Ishibe, Ikuhiro Sakata, Itaru Yanagihara   +9 more
doaj   +1 more source

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

Neurobiology of Disease, 2015
Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters.
E.L. von Rüden, R.M. Bogdanovic, C.T. Wotjak, H. Potschka   +3 more
doaj   +1 more source

Early and Divergent Lipid Mediator Remodelling in Fast Versus Slow Skeletal Muscles of Female hSOD1G93A Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy in amyotrophic lateral sclerosis (ALS) drives loss of muscle strength, function and quality of life in ALS patients. The endocannabinoid system (ECS) regulates muscle homeostasis via regenerative and metabolic processes, and although ECS alterations have been reported in ALS neural tissues, ECS remodelling ...
Sebastiaan Dalle, Kaat Vanderbeke, Thibaut Burg, Moniek Schouten, Wout Lauriks, Nicole Hersmus, Ludo Van Den Bosch, Katrien Koppo   +7 more
wiley   +1 more source

Constitutive increases in corticotropin releasing factor and fatty acid amide hydrolase drive an anxious phenotype

Biological Psychiatry, 2017
Background Corticotropin-releasing factor (CRF) mediates anxiogenic responses by activating CRF1 receptors in limbic brain regions. Anxiety is further modulated by the endogenous cannabinoid (eCB) system that attenuates the synaptic effects of stress. In
Luis A Natividad, Matthew W. Buczynski, M. Herman, Dean Kirson, Christopher S. Oleata, Cristina Irimia, I. Polis, R. Ciccocioppo, M. Roberto, L. Parsons   +9 more
semanticscholar   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Resmetirom Ameliorates Fibrogenesis in Hepatic Stellate Cells via Thyroid Hormone Receptor Alpha‐Fatty‐Acid Amide Hydrolase 1 Signaling Pathway

MedComm, Volume 7, Issue 8, August 2026.
1. Resmetirom attenuates the activation of HSCs induced in in vitro and in vivo models. 2. Resmetirom attenuates the activation of HSCs through its specific action on the thyroid hormone receptor alpha. 3. Resmetirom requires fatty‐acid amide hydrolase 1 to reduce HSC activation. ABSTRACT Resmetirom is a liver‐directed, thyroid hormone receptor β (THRβ)
Eva Novoa, Alba Cabaleiro, Borja López‐Picallo, Natalia da Silva Lima, Cristina Riobello, Carmen Pena, Jose Iglesias‐Moure, Ana Senra, Maria Luz Martínez‐Chantar, Anabel Fernandez‐Iglesias, Jordi Gracia‐Sancho, Susana Bravo, Carlos Dieguez, Marta Varela‐Rey, Vincent Prevot, Markus Schwaninger, Miguel López, Rubén Nogueiras   +17 more
wiley   +1 more source

The possible link between endocannabinoid system gene polymorphisms and overweight/obesity susceptibility in individuals living in the Marmara Region

Türk Biyokimya Dergisi
Obesity is a global health problem related to reduced life quality and shorter life expectancy. Given the fact that genetic factors play a role in obesity development, studies have suggested that polymorphisms of cannabinoid receptor 1 (CNR1 ...
Altun Beril, Cok İsmet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source