Results 81 to 90 of about 22,778 (210)

Methyl Jasmonate Seed Priming Mitigates the Defence‐Growth Trade‐Off and Tailors Plant Response to Specific Pests

Plant, Cell &Environment, EarlyView.
ABSTRACT Seed defence priming is emerging as a novel, cost‐efficient and environmentally safe tool for pest management. It has been proposed as a means to uncouple the defence‐growth trade‐off in plants by enhancing defence responses with minimal fitness costs, but the mechanisms underlying this role remain elusive.
Lucia Talavera‐Mateo, Adrian Sabater‐Gabriel, Alejandro Garcia, Marta Marina Perez‐Alonso, Rayko Halitschke, M. Estrella Santamaria   +5 more
wiley   +1 more source

An anatomical and temporal portrait of physiological substrates for fatty acid amide hydrolase[S]

Journal of Lipid Research, 2011
Fatty acid amide hydrolase (FAAH) regulates amidated lipid transmitters, including the endocannabinoid anandamide and its N-acyl ethanolamine (NAE) congeners and transient receptor potential channel agonists N-acyl taurines (NATs).
Jonathan Z. Long, Melanie LaCava, Xin Jin, Benjamin F. Cravatt   +3 more
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

The precise structures and stereochemistry of trihydroxy-linoleates esterified in human and porcine epidermis and their significance in skin barrier function: Implication of an epoxide hydrolase in the transformations of linoleate [PDF]

, 2016
Creation of an intact skin water barrier, a prerequisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty acid linoleate, which is esterified to the ω-hydroxyl of an epidermis-specific ceramide.
Boeglin, William E., Brash, Alan R., Calcutt, M. Wade, Chiba, Takahito, O'Donnell, Valerie B., Thomas, Christopher P.   +5 more
core   +1 more source

Modulation of the endocannabinoids N-Arachidonoylethanolamine (AEA) and 2-Arachidonoylglycerol (2-AG) on Executive Functions in Humans [PDF]

, 2013
Animal studies point to an implication of the endocannabinoid system on executive functions. In humans, several studies have suggested an association between acute or chronic use of exogenous cannabinoids (Δ9-tetrahydrocannabinol) and executive ...
A Bechara, A Busquets-Garcia, A Egerton, A Egerton, A Kofalvi, A Luchicchi, AB Fagundo, Amparo del Pino-Gutierrez, Ana B. Fagundo, Antoni Pastor, CD Verrico, CH Ashton, Cristina Botella, CT Whitlow, D Leung, D Robbe, DA Eldreth, DK Nomura, E Schlicker, EK Miller, Felipe F. Casanueva, Fernando Fernández-Aranda, Francisco J. Tinahones, G Marsicano, Gema Frühbeck, GL Gerdeman, HG Pope, Inés Moragrega, J Koppel, J McDonald, Javier Gómez-Ambrosi, JG Ramaekers, JJ Burston, Jose C. Fernández-García, Jose M. Fernández-Real, José M. Menchón, K Starowicz, K Tchanturia, KI Bolla, KI Bolla, L Lacroix, L Sokolic, LA Matsuda, M Beltramo, M Diana, M Egertova, M Egertova, M Herkenham, M Klugmann, M Maccarrone, M Pistis, MN Hill, MN Hill, MR Pazos, MR Stefani, MR Stefani, N Hajos, N Solowij, ND Volkow, P Lafenetre, P Monteleone, R Depoortere, Rafael de la Torre, RD Crean, RI Wilson, RJ Mathew, RJ Mathew, RK Stoving, RN Takahashi, Rosa Baños, Roser Granero, Roser Rodríguez, S Gaetani, S Mato, S Petrosino, SA Gruber, SA Varvel, SA Varvel, Salomé Tárrega, SD Lane, SJ Borgwardt, Susana Jiménez-Murcia, T Bisogno, T Lundqvist, T Ohno-Shosaku, T Pattij, T Rubino, T Rubino, T Sugiura, TJ De Vries, UN Danner, V Di Marzo, V Di Marzo, V Di Marzo, V Di Marzo, V Di Marzo, Vinod K. Yaragudri, WA Devane, Zaida Agüera   +98 more
core   +7 more sources

A case series of the dynamics of lipid mediators in patients with sepsis

Acute Medicine & Surgery, 2019
Background Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.
Mitsuhide Hamaguchi, Heng Ning Wu, Masahiro Tanaka, Noriko Tsuda, Ourlad Alzeus Gaddi Tantengco, Tomohide Matsushima, Takami Nakao, Takuya Ishibe, Ikuhiro Sakata, Itaru Yanagihara   +9 more
doaj   +1 more source

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Arthritis Research & Therapy, 2017
Background The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH)
Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev   +4 more
doaj   +1 more source

Endocannabinoids and striatal function: implications for addiction-related behaviours. [PDF]

, 2014
Since the identification and cloning of the major cannabinoid receptor expressed in the brain almost 25 years ago research has highlighted the potential of drugs that target the endocannabinoid system for treating addiction.
Belin, David, Dalley, Jeffrey W, Jupp, Bianca, Moreira, Fabricio A   +3 more
core   +2 more sources

Living Hydrogels: Harnessing Microorganism–Material Synergy for Next‐Generation Therapeutics

Advanced Science, Volume 13, Issue 25, 4 May 2026.
 . ABSTRACT Microorganism‐based therapies, particularly those utilizing probiotics, have emerged as a powerful biomedical strategy owing to their inherent living functionalities. These living systems can dynamically interact with host environments and self‐regulate their activity, offering superior adaptability, prolonged functionality, and ...
Shuifang Mao, Bingyao Bai, Xingqian Ye, Yiliang Lin   +3 more
wiley   +1 more source

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

Neurobiology of Disease, 2015
Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters.
E.L. von Rüden, R.M. Bogdanovic, C.T. Wotjak, H. Potschka   +3 more
doaj   +1 more source