Results 81 to 90 of about 13,359 (214)

Design and Synthesis of New A2B Adenosine Receptor Antagonists

, 2009
Starting from chemical structure of N-benzo-[1,3]dioxol-5-yl-2-[5-(2,6dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-1-methyl-1H-pyrazol3-yloxy]-acetamide, MRE2029F20* various structural modifications were realized to afford a new series of A2B ...
Baraldi, Stefania
core  

A case series of the dynamics of lipid mediators in patients with sepsis

Acute Medicine & Surgery, 2019
Background Bioactive lipid mediators play a crucial role during infection. Previously, we showed the expression level of FAAH mRNA in septic patients was lower than in healthy controls.
Mitsuhide Hamaguchi, Heng Ning Wu, Masahiro Tanaka, Noriko Tsuda, Ourlad Alzeus Gaddi Tantengco, Tomohide Matsushima, Takami Nakao, Takuya Ishibe, Ikuhiro Sakata, Itaru Yanagihara   +9 more
doaj   +1 more source

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Arthritis Research & Therapy, 2017
Background The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH)
Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev   +4 more
doaj   +1 more source

Inhibition of monoacylglycerol lipase mediates a cannabinoid 1-receptor dependent delay of kindling progression in mice

Neurobiology of Disease, 2015
Endocannabinoids, including 2-arachidonoylglycerol (2-AG), activate presynaptic cannabinoid type 1 receptors (CB1R) on inhibitory and excitatory neurons, resulting in a decreased release of neurotransmitters.
E.L. von Rüden, R.M. Bogdanovic, C.T. Wotjak, H. Potschka   +3 more
doaj   +1 more source

A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase [PDF]

, 2013
In addition to inhibiting the cyclooxygenase (COX)-mediated biosynthesis of prostanoids, various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid ...
Paola Magotti, Marco De Vivo, Lambruschini, Chiara, De Vivo, Marco, Gianpiero Garau, Laura Bertolacci, Chiara Lambruschini, Romeo, Elisa, Albani, Clara, CAVALLI, ANDREA, Bertolacci, Laura, Garau, Gianpiero, Marina Veronesi, Dionisi, Mauro, Elisa Romeo, Mauro Dionisi, Clara Albani, Rita Scarpelli, Magotti, Paola, Scarpelli, Rita, Piomelli, Daniele, Veronesi, Marina, Daniele Piomelli   +22 more
core   +1 more source

The possible link between endocannabinoid system gene polymorphisms and overweight/obesity susceptibility in individuals living in the Marmara Region

Türk Biyokimya Dergisi
Obesity is a global health problem related to reduced life quality and shorter life expectancy. Given the fact that genetic factors play a role in obesity development, studies have suggested that polymorphisms of cannabinoid receptor 1 (CNR1 ...
Altun Beril, Cok İsmet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Cannabinoids for the control of experimental multiple sclerosis

, 2010
PhDThere have been numerous studies reporting that cannabinoids, both exogenous and endogenous, have a potential beneficial function during incidences of neurological damage.
Pryce, Gareth
core  

Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase

, 2016
Sulfonyl fluorides are known to inhibit esterases. Early work from our laboratory has identified hexadecyl sulfonylfluoride (AM374) as a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH).
Spyros P. Nikas (1314939), Shakiru O. Alapafuja (2019913), Alexandros Makriyannis (32548), Vidyanand G. Shukla (2019916), Mahmoud L. Nasr (2019907), Nikolai Zvonok (309311), Jing Li (10611), Anna L. Bowman (309318), Xiaomeng Shi (839260), Indu T. Bharathan (2019910), John R. Engen (233440)   +10 more
core   +1 more source