Results 91 to 100 of about 20,213 (210)

Early blockade of joint inflammation with a fatty acid amide hydrolase inhibitor decreases end-stage osteoarthritis pain and peripheral neuropathy in mice

Arthritis Research & Therapy, 2017
Background The endocannabinoid system has been shown to reduce inflammatory flares and pain in rodent models of arthritis. A limitation of endocannabinoids is that they are rapidly denatured by hydrolysing enzymes such as fatty acid amide hydrolase (FAAH)
Jason J. McDougall, Milind M. Muley, Holly T. Philpott, Allison Reid, Eugene Krustev   +4 more
doaj   +1 more source

The Relationship Between (Endo)cannabinoids, the Microbiome and Melanoma

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
CB1 and CB2 receptors are widely distributed in both normal and cancerous cells. Cannabinoids have a positive impact on reducing tumor growth in mice. A positive relationship exists between CB2 receptors and survival in skin melanoma. However, there is a negative impact on non‐small cell lung cancer and colon cancer, whereas a higher association of CB1
Farideh A. Javid, Marin Golčić, Anja Harej Hrkać, Andrej Belančić   +3 more
wiley   +1 more source

Phenolic compounds from nutmeg (Myristica fragrans Houtt.) inhibit the endocannabinoid‐modulating enzyme fatty acid amide hydrolase

The Journal of pharmacy and pharmacology, 2019
The study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) enzymes.
A. El-Alfy, E. Abourashed, C. Patel, Nunmoula Mazhari, HeaRe An, A. Jeon   +5 more
semanticscholar   +1 more source

Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum

BMC Microbiology, 2012
Background Anandamide (Arachidonoyl ethanolamide) is a potent bioactive lipid studied extensively in humans, which regulates several neurobehavioral processes including pain, feeding and memory.
Neelamegan Dhamodharan, Schoenhofen Ian C, Richards James C, Cox Andrew D   +3 more
doaj   +1 more source

Mutasynthesis and Antibiotic Activity of Mupirocin Analogues

ChemBioChem, Volume 27, Issue 13, 14 July 2026.
A mutasynthetic strategy was developed to prepare pseudomonic acid analogues, and their antimicrobial activities were evaluated against five bacterial strains. Feeding studies with mutant strains of Pseudomonas fluorescens revealed that C7‐desepoxy‐PA‐B was metabolised to C7‐PA‐C with loss of the 8‐hydroxyl group, but no fatty acid chain extension ...
Sarah M. Husain, Luoyi Wang, Li‐Chen Han, James I. Bowen, Zhongshu Song, Felix de Courcy‐Ireland, Ashley J. Winter, Thomas J. Simpson, Paul R. Race, James Spencer, Matthew P. Crump, Christine L. Willis   +11 more
wiley   +1 more source

Fatty Acid Amide Hydrolase Inhibition by JNJ‐42165279: A Multiple‐Ascending Dose and a Positron Emission Tomography Study in Healthy Volunteers

Clinical and Translational Science, 2018
Inhibition of fatty acid amide hydrolase (FAAH) potentiates endocannabinoid activity and is hypothesized to have therapeutic potential for mood and anxiety disorders and pain.
Andrey Postnov, M. Schmidt, D. Pemberton, J. D. de Hoon, A. van Hecken, Maarten van den Boer, P. Zannikos, P. D. van der Ark, J. Palmer, S. Rassnick, Sofie Celen, G. Bormans, K. Van Laere   +12 more
semanticscholar   +1 more source

Role of Steroids on the Membrane Binding Ability of Fatty Acid Amide Hydrolase

Cannabis and Cannabinoid Research, 2019
Background: Fatty acid amide hydrolase (FAAH) is a membrane-bound homodimeric enzyme that gets in contact with a lipophilic substrate in the lipid bilayer, and then cleaves it into water soluble products.
A. Sabatucci, Monica Simonetti, D. Tortolani, Clotilde B Angelucci, E. Dainese, M. Maccarrone   +5 more
semanticscholar   +1 more source

Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration

Redox Biology, 2018
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism.
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska   +5 more
doaj   +1 more source

Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats

The Journal of pharmacy and pharmacology, 2019
URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, exerts profound analgesic effects in animal models. We examined, in rats, (1) the pharmacokinetic profile of oral URB937; (2) the compound's ability to elevate levels of the representative
Valentina Vozella, Faizy Ahmed, Paoula Choobchian, Collin B. Merrill, Cristina Zibardi, G. Tarzia, M. Mor, A. Duranti, A. Tontini, S. Rivara, D. Piomelli   +10 more
semanticscholar   +1 more source

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy

Frontiers in Pharmacology, 2019
Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed.
Robert Ramer, Rico Schwarz, Burkhard Hinz   +2 more
doaj   +1 more source