Results 91 to 100 of about 22,778 (210)

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source

Therapeutic potential of fatty acid amide hydrolase, monoacylglycerol lipase, and N-acylethanolamine acid amidase inhibitors [PDF]

, 2016
Fatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to alleviate pain and inflammation, regulate motility and appetite, and produce anti-cancer, anxiolytic, and neuroprotective efficacies via cannabinoid receptor type 1 (CB1) or ...
Chavatte, Philippe, Leleu-Chavain, Natascha, Millet, Regis, Sansook, Supojjanee, Spencer, John, Tuo, Wei   +5 more
core   +3 more sources

Carbohydrate‐Based Drug Discovery: Synthetic Strategies and Clinical Applications

Israel Journal of Chemistry, Volume 66, Issue 3, May 2026.
The picture depicts the molecules discussed in the review. On the left side, the general scaffold of sugars is shown. Next to it are four carbohydrate‐based molecules, including remdesivir, islatravir, empagliflozin, and Globo‐H. Remdesivir and islatravir contain a substituted ribose ring attached to a modified nucleobase.
Stephan Scheeff, Jemma Arakelyan, Billy Wai‐Lung Ng   +2 more
wiley   +1 more source

The possible link between endocannabinoid system gene polymorphisms and overweight/obesity susceptibility in individuals living in the Marmara Region

Türk Biyokimya Dergisi
Obesity is a global health problem related to reduced life quality and shorter life expectancy. Given the fact that genetic factors play a role in obesity development, studies have suggested that polymorphisms of cannabinoid receptor 1 (CNR1 ...
Altun Beril, Cok İsmet, Noyan Cemal Onur, Kadioglu Ela, Cetin Alptekin, Sengezer Tijen, Altintas Merih, Kurnaz Samet, Dilbaz Nesrin   +8 more
doaj   +1 more source

A novel aryl acylamidase from Nocardia farcinica hydrolyses polyamide [PDF]

, 2009
An alkali stable polyamidase was isolated from a new strain of Nocardia farcinica. The enzyme consists of four subunits with a total molecular weight of 190 kDa.
Almansa, Asatekin, Cai, Ciskanik, Cramp, De Geyter, Deguchi, Fischer-Colbrie, Fournand, Friedrich, Fujisawa, Gudelj, Guebitz, Hammond, Hayashi, Heumann, Hirrlinger, Hwang, Ishikawa, Jaganathan, Kakudo, Kim, Klun, Krieg, Labahn, Li, Lowry, McCord, Meyer, Negoro, Negoro, Nomura, Qiao, Saitou, Silva, Skouloubris, Thompson, Toogood, Tusek, Valina, Vertommen, Wu, Yoshioka   +42 more
core   +1 more source

Endocannabinoid system gene expression in mesocorticolimbic brain regions of individuals with alcohol use disorder: A descriptive study

Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.
Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez, Abraham Bailén Torregrosa, Francisco Navarrete, Auxiliadora Aracil‐Fernández, Gabriel Rubio, Jorge Manzanares   +5 more
wiley   +1 more source

Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum

BMC Microbiology, 2012
Background Anandamide (Arachidonoyl ethanolamide) is a potent bioactive lipid studied extensively in humans, which regulates several neurobehavioral processes including pain, feeding and memory.
Neelamegan Dhamodharan, Schoenhofen Ian C, Richards James C, Cox Andrew D   +3 more
doaj   +1 more source

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

The faah gene is the first direct target of estrogen in the testis: role of histone demethylase LSD1 [PDF]

, 2012
Estrogen (E(2)) regulates spermatogenesis, yet its direct target genes have not been identified in the testis. Here, we cloned the proximal 5' flanking region of the mouse fatty acid amide hydrolase (faah) gene upstream of the luciferase reporter gene ...
Di Giacomo, D, Di Siena, S, Geremia, R, Grimaldi, P, Maccarrone, M, Pirazzi, V, Pucci, M   +6 more
core   +1 more source

Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review

Microcirculation, Volume 33, Issue 4, May 2026.
ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias, Francisco M. Vila‐Real, Maria A. Vieira‐Coelho   +2 more
wiley   +1 more source