Results 91 to 100 of about 13,359 (214)

Identification and recombinant expression of anandamide hydrolyzing enzyme from Dictyostelium discoideum

open access: yesBMC Microbiology, 2012
Background Anandamide (Arachidonoyl ethanolamide) is a potent bioactive lipid studied extensively in humans, which regulates several neurobehavioral processes including pain, feeding and memory.
Neelamegan Dhamodharan   +3 more
doaj   +1 more source

Metabolism‐Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing

open access: yesAdvanced Science, Volume 13, Issue 33, 15 June 2026.
Metabolic differences emerging after antibiotic exposure provide rapid phenotypic signals of susceptibility and resistance. This review summarizes metabolic biomarkers for rapid phenotypic AST, associated with nutrient uptake, respiratory activity, metabolic reprogramming, and enzymatic function. ABSTRACT The accelerating global crisis of antimicrobial
Sha Yu   +7 more
wiley   +1 more source

The pharmacological inhibition of Fatty acid amide hydrolase ameliorates several aspects of the Alzheimer's-like phenotype in 3xTg-AD mice

open access: yes, 2018
Objectives: Acylethanolamides can exert neuroprotective/anti-inflammatory effects in Alzheimer’s disease (AD). The pharmacological inhibition of the enzyme fatty acid amide hydrolase (FAAH) can increase the endogenous tone of acylethanolamides, such as ...
Bedse Gaurav   +7 more
core  

Conservation Status of Two Italian Local Poultry Breeds: Faraona Camosciata and Oca Padovana

open access: yesAnimal Genetics, Volume 57, Issue 3, June 2026.
ABSTRACT The present study aimed to assess the conservation status and characterize the phenotypic and genomic diversity of two endangered Italian poultry genetic resources to guide their conservation plans. Blood samples and morphometric data were collected on 50 Faraona Camosciata (FAC, Numida meleagris) and 50 Oca Padovana (OPD, Anser anser) adult ...
Filippo Cendron   +7 more
wiley   +1 more source

Chronic inhibition of fatty acid amide hydrolase ameliorates the Alzheimer-like phenotype in 3xTg-AD mice

open access: yes, 2018
Objectives: Acylethanolamides can exert neuroprotective/anti-inflammatory effects in Alzheimer’s disease (AD). The inhibition of the enzyme fatty acid amide hydrolase (FAAH) can increase the endogenous tone of acylethanolamides, such as anandamide.
Bedse Gaurav   +7 more
core  

Ginseng polysaccharides prevent mastitis through Lactobacillus murinus‐derived deoxycholic acid and TGR5 signaling

open access: yesiMetaOmics, Volume 3, Issue 2, June 2026.
Prebiotic Ginseng polysaccharides (GP) alleviate mastitis through selective enrichment of gut L. murinus, which elevates its anti‐inflammatory metabolite deoxycholic acid (DCA). Circulating DCA engages mammary epithelial TGR5 receptors, triggering the cAMP–PKA pathway to suppress NF‐κB/NLRP3‐mediated inflammation.
Zhijie Zheng   +15 more
wiley   +1 more source

The Role of N6‐Methyladenosine Modification in Health and Disease

open access: yesMedComm, Volume 7, Issue 6, June 2026.
N6‐methyladenosine (m6A) is the most prevalent internal RNA modification in eukaryotes, acting as a pivotal epitranscriptomic regulator of RNA metabolism. This modification plays a dual role: it maintains physiological homeostasis under normal conditions but drives disease progression when dysregulated.
Linghuan Li   +6 more
wiley   +1 more source

Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate

open access: yes, 2016
A series of aryl piperazinyl ureas that act as covalent inhibitors of fatty acid amide hydrolase (FAAH) is described. A potent and selective (does not inhibit FAAH-2) member of this class, JNJ-40355003, was found to elevate the plasma levels of three ...
William Jones (1429504)   +19 more
core   +1 more source

Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration

open access: yesRedox Biology, 2018
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism.
Michał Biernacki   +5 more
doaj   +1 more source

Effect of environmental temperature on oxidative status, inflammatory response and endocannabinoid system at oestrus in dairy cows

open access: yesVeterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Heat stress (HS) poses a significant challenge to dairy production under climate change, as it compromises fertility, productivity and overall health in cows. This seasonal observational cross‐sectional study investigated how environmental temperature affects oxidative status, inflammatory responses and endocannabinoid system (ECS ...
Alice Carbonari   +10 more
wiley   +1 more source

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