Results 101 to 110 of about 20,213 (210)

Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?

General Psychiatry, Volume 39, Issue 4, August 2026.
Peng Wei, Pianpian Zhao, Zenghui Gu, Mengyuan Yang, David Karasik, Ching‐Lung Cheung, Houfeng Zheng   +6 more
wiley   +1 more source

Role for fatty acid amide hydrolase (FAAH) in the leptin-mediated effects on feeding and energy balance

Proceedings of the National Academy of Sciences of the United States of America, 2018
Significance We present evidence that an endocannabinoid-dependent signaling mechanism contributes to the hypophagic actions of leptin. Specifically, leptin increases fatty acid amide hydrolase (FAAH) activity and reduces N-arachidonoylethanolamine ...
G. Balsevich, Martin A Sticht, Nicole P. Bowles, Arashdeep Singh, Tiffany T.‐Y. Lee, Zhiying Li, P. Chelikani, F. Lee, S. Borgland, C. Hillard, B. McEwen, Matthew N Hill   +11 more
semanticscholar   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well ...
Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarrone   +8 more
doaj   +1 more source

Inhibition of Fatty Acid Amide Hydrolase (FAAH) by Macamides

The FASEB Journal, 2018
Purpose Pentane extract of the Peruvian plant Lepidium meyenii (Maca) has been demonstrated to possess neuroprotective activity in previous studies. This extract contains several macamides that might act on the endocannabinoid system.
M. Alasmari, M. Bӧhlke, C. Kelley, T. Maher, A. Pino-Figueroa   +4 more
openaire   +2 more sources

Transcriptional regulation of the endocannabinoid system in a rat model of binge‐eating behavior reveals a selective modulation of the hypothalamic fatty acid amide hydrolase gene

International Journal of Eating Disorders, 2018
OBJECTIVE Binge-eating episodes are recurrent and are defining features of several eating disorders. Thus binge-eating episodes might influence eating disorder development of which exact underlying mechanisms are still largely unknown.
M. Pucci, M. V. Micioni Di Bonaventura, E. Zaplatić, F. Bellia, M. Maccarrone, C. Cifani, C. D'Addario   +6 more
semanticscholar   +1 more source

Pharmacophore modeling and virtual screening for the discovery of new fatty acid amide hydrolase inhibitors

Acta Pharmaceutica Sinica B, 2011
A predictive pharmacophore model has been generated from a series of diverse fatty acid amide hydrolase (FAAH) inhibitors and the optimal pharmacophore model applied in virtual screening.
Dong-sheng Zhao, Hai-yan Wang, Zhi-hui Lian, Da-xiong Han, Xin Jin   +4 more
doaj   +1 more source

Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.

PLoS ONE, 2012
BackgroundWhile the etiology of depression is not clearly understood at the present time, this mental disorder is thought be a complex and multifactorial trait with important genetic and environmental contributing factors.Methodology/principal ...
K Yaragudri Vinod, Shan Xie, Delphine Psychoyos, Basalingappa L Hungund, Thomas B Cooper, Shanaz M Tejani-Butt   +5 more
doaj   +1 more source

Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

Proceedings of the National Academy of Sciences of the United States of America, 2001
B. Cravatt, K. Demarest, M. Patricelli, M. Bracey, Dan K. Giang, B. Martin, A. Lichtman   +6 more
semanticscholar   +1 more source

Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. [PDF]

Int J Mol Sci, 2023
Kovacs D, Flori E, Bastonini E, Mosca S, Migliano E, Cota C, Zaccarini M, Briganti S, Cardinali G.   +8 more
europepmc   +1 more source

Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening

CHIMIA
Serine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation.
Franciscus H. G. ter Brake, Patrick Rehorst, Machiel W. Henst, Mario van der Stelt, Antonius P. A. Janssen   +4 more
doaj   +1 more source