Results 101 to 110 of about 13,359 (214)

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy

Frontiers in Pharmacology, 2019
Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed.
Robert Ramer, Rico Schwarz, Burkhard Hinz   +2 more
doaj   +1 more source

Altitude‐Associated Divergence of the Gut Microbiome in Endangered Forest Musk Deer: Evidence From Integrated Metagenomics, Metabolomics, and Culturomics

Evolutionary Applications, Volume 19, Issue 6, June 2026.
ABSTRACT High‐altitude environments expose mammals and their gut symbionts to multifaceted stressors—hypoxia, cold, and intense UV radiation. Whether gut microbial communities undergo compositional restructuring in response to these stressors, and whether such restructuring carries translational value for captive conservation, remain unresolved ...
Feiyun Huang, Zexiu Zhang, Yanni Zhao, Sen Ye, Maoyuan Gan, Xuxin Li, Yele Zhang, Lei Chen, Yushuo Zhang, Lingxi Chen, Ting Wang, Jinming Huang, Xiuyue Zhang   +12 more
wiley   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well ...
Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarrone   +8 more
doaj   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Fluctuations of fatty acid amide hydrolase and anandamide levels during the human ovulatory cycle

, 2004
Implantation is possible within a defined period of the menstrual cycle, referred to as the 'implantation window'. It is during this critical period that proper dialog can be established between the blastocyst and a receptive endometrium.
Finazzi-Agro A, Maccarrone M, Lazzarin N, Battista N, Ubaldi F, Valensise H, Bari M   +6 more
core   +1 more source

Prospective, Double‐Blind, Vehicle‐Controlled Assessment of Topical Bakuchiol on Photoaging in a Chinese Population

Journal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Aging skin is a universal complaint among diverse patient populations. It encompasses physiologic changes to the skin, such as skin laxity, dyspigmentation, fine lines, and wrinkles. However, different populations may show different signs of aged skin.
Zill‐e‐human Khan, Ratan K. Chaudhuri, Ajay Dulai, Anurag Tarmaster, Libing Pan, Raja K. Sivamani   +5 more
wiley   +1 more source

Structural analysis of a plant fatty acid amide hydrolase provides insights into the evolutionary diversity of bioactive acylethanolamides

, 2019
Article reporting the three-dimensional crystal structures of the signal-terminating enzyme fatty acid amide hydrolase (FAAH) from Arabidopsis in its apo and ligand-bound forms at 2.1- and 3.2-Å resolutions ...
Wang, Xiaoqiang, Chapman, Kent Dean, Bankaitis, Vytas A., Tripathi, Ashutosh, Aziz, Mina   +4 more
core   +1 more source

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Journal of Lipid Research, 2005
N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel, Erica J. Carrier, W-S. Vanessa Ho, David J. Rademacher, Sonya Cunningham, D. Sudarshan Reddy, J.R. Falck, Benjamin F. Cravatt, Cecilia J. Hillard   +8 more
doaj   +1 more source

Enol carbamate derivatives as modulators of fatty Acid Amide Hydrolase

, 2009
The invention provides novel enol carbamate derivatives of formula (I) for inhibiting Fatty Acid Amide Hydrolase (FAAH), compositions that include such compounds as well as methods of treating diseases of energy metabolism, central nervous system ...
Minetti, P., Merlini, L., Cabri W, Caprioli, A., Penco, S., Maccarrone. , M., Dallavalle, S, Borsini, F.   +7 more
core  

Inhibition of microglial fatty acid amide hydrolase modulates LPS stimulated release of inflammatory mediators

, 2007
Anandamide and other fatty acid amides are metabolised by the enzyme fatty acid amide hydrolase (FAAH), which thereby regulates their endogenous levels. Here we demonstrate that cultured rat cortical microglia express FAAH at low levels.
Lin Luo, Webb, Michael, Michael Webb, Tham, Chui-Se, Whitaker, John, Chui-Se Tham, Luo, Lin, John Whitaker   +7 more
core   +1 more source