Results 101 to 110 of about 22,778 (210)

Interplay between n-3 and n-6 long-chain polyunsaturated fatty acids and the endocannabinoid system in brain protection and repair. [PDF]

, 2017
The brain is enriched in arachidonic acid (ARA) and docosahexaenoic acid (DHA), long-chain polyunsaturated fatty acids (LCPUFA) of the n-6 and n-3 series, respectively. Both are essential for optimal brain development and function.
A Artmann, A Berger, A Bilkei-Gorzo, A Chicca, A Nadjar, A Petroni, A Piyanova, A Tanimura, A Thomazeau, A Thomazeau, A Viader, AA Farooqui, AE Bonnet, AF Domenichiello, AJ Vecchio, AL Groeger, AM Fjell, AP Simopoulos, B Batetta, B Lands, B Lu, BM Fonseca, BN Ames, C Arnold, C Canugovi, C Cipollina, CD Breder, CD Buckley, CE Ramsden, CN Serhan, CN Serhan, CN Serhan, CN Serhan, CT Chen, D Bagga, D Ehninger, D Kempuraj, D Leung, D Piomelli, D Rueda, DK Nomura, E Lien, E Mantzioris, E Molina-Holgado, E Ryberg, EA Placzek, EM Novak, ES Onaivi, G Kaur, GA Garden, GF Grabner, H Sprecher, H Yang, H Yang, HG Kuhn, I Galve-Roperh, I Katona, I Matias, J Liu, JC DeMar Jr, JC Demar Jr, JE Tungen, JF Quinn, JL Harrison, JM Parent, JP Pan, JR Savinainen, JT Wood, JW Phillis, JY Xu, K Jin, K Tsuboi, K Yamagata, K Yurko-Mauro, KD Patel, KD Stark, KE Hopperton, KS Broughton, L Belayev, L Petrocellis De, M Alhouayek, M Aursnes, M Gabbs, M Gabrielli, M Kano, M Lafourcade, M Mecha, M Ouellet, M Perluigi, M Zhu, MA Rashid, MB Goncalves, ME Tremblay, MG Cascio, MK Gregory, MR Flock, MV Sofroniew, MV Sofroniew, N Murataeva, N Murataeva, N Stella, NG Bazan, NG Bazan, NG Bazan, NG Bazan, NR Yerram, P Urquhart, PE Castillo, PJ Jones, PK Yip, R Luostarinen, R Micha, R Yang, RJ Kulmacz, S Forsyth, S Watanabe, S Zelasko, SA Moore, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Dyall, SC Strike, SE O’Sullivan, Simon C. Dyall, SN Lim, SU Kim, T Aguado, T Bartsch, T Cassano, T Cederholm, T Larrieu, T Takizawa, TVP Bliss, V Chhor, V Darsalia, V Marzo Di, V Marzo Di, V Smedt-Peyrusse De, W Jiang, WL Huang, X Chen, Y Marchalant, Y Takagi, Y Tian, YC Yung, ZZ Xu   +147 more
core   +1 more source

Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration

Redox Biology, 2018
Primary and secondary hypertension is associated with kidney redox imbalance resulting in enhanced reactive oxygen species (ROS) and enzymes dependent phospholipid metabolism.
Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska   +5 more
doaj   +1 more source

Modulation of the Endocannabinoid System as a Potential Anticancer Strategy

Frontiers in Pharmacology, 2019
Currently, the involvement of the endocannabinoid system in cancer development and possible options for a cancer-regressive effect of cannabinoids are controversially discussed.
Robert Ramer, Rico Schwarz, Burkhard Hinz   +2 more
doaj   +1 more source

Targeting the Endocannabinoid Metabolic Enzymes to Reduce Inflammatory Pain [PDF]

, 2014
Pain is a debilitating condition that presents a problem of clinical relevance. Common analgesics include opioids and non-steroidal anti-inflammatory drugs (NSIADs).
Ghosh, Sudeshna
core   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well ...
Filomena Fezza, Sergio Oddi, Monia Di Tommaso, Chiara De Simone, Cinzia Rapino, Nicoletta Pasquariello, Enrico Dainese, Alessandro Finazzi-Agrò, Mauro Maccarrone   +8 more
doaj   +1 more source

α-Ketoheterocycle-Based Inhibitors of Fatty Acid Amide Hydrolase (FAAH)

ACS Chemical Neuroscience, 2012
A summary of the initial discovery and characterization of the enzyme fatty acid amide hydrolase (FAAH), and the subsequent advancement of an important class of competitive, reversible, potent and selective inhibitors is presented. Initially explored using substrate-inspired inhibitors bearing electrophilic carbonyls, the examination of α ...
Katerina, Otrubova, Dale L, Boger
openaire   +3 more sources

Fatty acid amide hydrolase inhibitors: a patent review (2009 – 2014)

Expert Opinion on Therapeutic Patents, 2015
Fatty acid amide hydrolase (FAAH) is a key enzyme responsible for the degradation of the endocannabinoid anandamide. FAAH inactivation is emerging as a strategy to treat several CNS and peripheral diseases, including inflammation and pain. The search for effective FAAH inhibitors has thus become a key focus in present drug discovery.Patents and patent ...
LODOLA, Alessio, CASTELLI, Riccardo, MOR, Marco, RIVARA, Silvia   +3 more
openaire   +3 more sources

The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity

Journal of Lipid Research, 2005
N-Arachidonylethanolamine (AEA) accumulates during brain injury and postmortem. Because fatty acid amide hydrolase (FAAH) regulates brain AEA content, the purpose of this study was to determine its role in the postmortal accumulation of AEA using FAAH ...
Sachin Patel, Erica J. Carrier, W-S. Vanessa Ho, David J. Rademacher, Sonya Cunningham, D. Sudarshan Reddy, J.R. Falck, Benjamin F. Cravatt, Cecilia J. Hillard   +8 more
doaj   +1 more source

Design, synthesis and biological evaluation of heterocyclic derivatives as potential MAGL inhibitors. [PDF]

, 2012
Facoltà di Farmacia Corso di laurea in Chimica e tecnologia farmaceutica; Relatore: prof.ssa C.Manera, dott.ssa F.Castelli; SSD: CHIM 08 Candidato: Gianfilippo Martello Titolo tesi: Design, synthesis and biological evaluation of heterocyclic derivatives ...
MARTELLO, GIANFILIPPO
core  

Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.

PLoS ONE, 2012
BackgroundWhile the etiology of depression is not clearly understood at the present time, this mental disorder is thought be a complex and multifactorial trait with important genetic and environmental contributing factors.Methodology/principal ...
K Yaragudri Vinod, Shan Xie, Delphine Psychoyos, Basalingappa L Hungund, Thomas B Cooper, Shanaz M Tejani-Butt   +5 more
doaj   +1 more source