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Fatty acid amide hydrolase substrate specificity
Bioorganic & Medicinal Chemistry Letters, 2000Fatty acid amide hydrolase (FAAH), also referred to as oleamide hydrolase and anandamide amidohydrolase, is a serine hydrolase responsible for the degradation of endogenous oleamide and anandamide, fatty acid amides that function as chemical messengers.
D L, Boger +5 more
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Plant fatty acid (ethanol) amide hydrolases
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2006Fatty acid amide hydrolase (FAAH) plays a central role in modulating endogenous N-acylethanolamine (NAE) levels in vertebrates, and, in part, constitutes an "endocannabinoid" signaling pathway that regulates diverse physiological and behavioral processes in animals.
Rhidaya, Shrestha +4 more
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Novel inhibitors of fatty acid amide hydrolase
Bioorganic & Medicinal Chemistry Letters, 2007A class of bisarylimidazole derivatives are identified as potent inhibitors of the enzyme fatty acid amide hydrolase (FAAH). Compound 17 (IC(50)=2 nM) dose-dependently (0.1-10mg/kg, iv) potentiates the effects of exogenous anandamide (1 mg/kg, iv) in a rat thermal escape test (Hargreaves test), and shows robust antinociceptive activity in animal models
S Y, Sit +6 more
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The Journal of Pharmacology and Experimental Therapeutics, 2002
Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide. Both anandamide and oleamide produce behavioral effects indicative of cannabinoid activity, but only anandamide binds the cannabinoid (CB1) receptor in vitro.
Aron H, Lichtman +3 more
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Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide. Both anandamide and oleamide produce behavioral effects indicative of cannabinoid activity, but only anandamide binds the cannabinoid (CB1) receptor in vitro.
Aron H, Lichtman +3 more
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Fatty Acid Amide Hydrolase: An Integrative Clinical Perspective
Cannabis & Cannabinoid Research, 2023Introduction: Fatty acid amide hydrolase (FAAH) is one of the main terminating enzymes of the endocannabinoid system (ECS). Since being discovered in 1996, the modulation of FAAH has been viewed as a compelling alternative strategy to obtain the beneficial effect of the ECS.
Anugrah D. Santoso, Dirk De Ridder
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Fatty Acid Amide Hydrolase Inhibitors – Progress and Potential
CNS & Neurological Disorders - Drug Targets, 2011Fatty acid amide hydrolase (FAAH) is responsible for hydrolysis of endocannabinoid, anandamide (AEA), and N-acyl ethanolamines such as palmitoylethanolamine (PEA) and N-oleoylethanolamide (OEA). Genetic deletion or pharmacological inactivation of FAAH shows site-specific elevation of AEA that plays a role in the modulation of pain and other ...
Khanna, Ish K. +1 more
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Analysis of Fatty Acid Amide Hydrolase Activity in Plants
2013N-Acylethanolamines (NAEs) are fatty acid derivatives amide-linked to ethanolamine. NAEs vary in chain lengths and numbers of double bonds and generally reflect the fatty acids found in membrane lipids in the tissues in which they reside. NAEs are present naturally in trace amounts and occur in a wide range of organisms including plants, animals, and ...
Sang-Chul, Kim +2 more
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