Results 121 to 130 of about 13,359 (214)

Fatty acid amide hydrolase (FAAH) [PDF]

Science-Business eXchange, 2010
openaire   +3 more sources

Biochemical Characterization of Tomato Fatty Acid Amide Hydrolase

, 2017
Fatty Acid Amide Hydrolase (FAAH), a serine hydrolase family protein, hydrolyzes N-acylethanolamines (NAEs) by cleaving the amide bond linking the acyl group with ethanolamine to produce free fatty acids.
Kilaru, Aruna, Shrestha, Sujan
core  

Multiplexed Gel-based ABPP Strategy for Target-agnostic Serine Hydrolase Inhibitor Screening

CHIMIA
Serine hydrolases (SHs) represent a functionally defined enzyme class with significant roles in human physiology, yet many of the approximately 240 human SH’s lack selective chemical inhibitors required for functional validation.
Franciscus H. G. ter Brake, Patrick Rehorst, Machiel W. Henst, Mario van der Stelt, Antonius P. A. Janssen   +4 more
doaj   +1 more source

Ex vivo lipidomics reveal monoacylglycerols as substrates for a fatty acid amide hydrolase in the legume Medicago truncatula

This article states that fatty acid amide hydrolase (FAAH) is a conserved hydrolase in eukaryotes with promiscuous activity toward a range of acylamide substrates.
Arias-Gaguancela, Omar, Chapman, Kent Dean, Herrell, Emily   +2 more
core   +1 more source

Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin

, 2007
There is evidence in the literature that the nonsteroidal anti-inflammatory drugs indomethacin and ibuprofen can interact with the cannabinoid system both in vitro and in vivo.
COCCO MT, VANDEVOORDE S, ONNIS, VALENTINA, HOLT S, BOLDRUP L, ALAJAKKU K, PAYLOR B, SUNDSTROM A, FOWLER CJ   +8 more
core   +1 more source

Therapeutic Potential of Fatty Acid Amide Hydrolase, Monoacylglycerol Lipase, and N -Acylethanolamine Acid Amidase Inhibitors

, 2016
International audienceFatty acid ethanolamides (FAEs) and endocannabinoids (ECs) have been shown to alleviate pain and inflammation, regulate motility and appetite, and produce anticancer, anxiolytic, and neuroprotective efficacies via cannabinoid ...
Sansook, Supojjanee, Regis Millet (16239371), Chavatte, Philippe, Spencer, John, Tuo, Wei, Natascha Leleu-Chavain (3130482), Supojjanee Sansook (3130485), Millet, Régis, John Spencer (4461472), Leleu-Chavain, Natascha, Wei Tuo (3130491), Philippe Chavatte (655568)   +11 more
core   +1 more source

Fatty acid amide hydrolase (FAAH) [PDF]

Science-Business eXchange, 2013
openaire   +3 more sources

Fatty acid amide hydrolase inhibition for the symptomatic relief of Parkinson's disease

Elements of the endocannabinoid system are strongly expressed in the basal ganglia where they suffer profound rearrangements after dopamine depletion. Modulation of the levels of the endocannabinoid 2-arachidonoyl-glycerol by inhibiting monoacylglycerol ...
Ramírez, María J., Fernández Suárez, Diana, Maldonado, Rafael, 1961-, Echeverry Alzate, Víctor, López Moreno, José A., Rojo Bustamante, Estefanía, Aymerich, María S., Hillard, Cecilia J., Oyarzábal, Julen, Celorrio, Marta, Franco, Rafael   +10 more
core  

Genetic Knockout of Fatty Acid Amide Hydrolase Ameliorates Cisplatin-Induced Nephropathy in Mice. [PDF]

Mol Pharmacol, 2023
Chen C, Wang W, Raymond M, Ahmadinejad F, Poklis JL, Em B, Gewirtz DA, Lichtman AH, Li N.   +8 more
europepmc   +1 more source

Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides. [PDF]

Sci Rep, 2023
Arias-Gaguancela O, Herrell E, Aziz M, Chapman KD.   +3 more
europepmc   +1 more source