Results 111 to 120 of about 13,359 (214)

Lack of Association between C385A Functional Polymorphism of the Fatty Acid Amide Hydrolase Gene and Polycystic Ovary Syndrome.

, 2013
The endocannabinoid system contributes to the regulation of appetite, food intake and energy balance. Fatty acid amide hydrolase is responsible for degradating anandamide, a key messenger of the endocannabinoid system.
Rácz, Károly, Grolmusz, Vince Kornél, Reismann, Péter, Stenczer, B., Fekete, T., Patócs, Attila Balázs, Szendei, G.   +6 more
core   +1 more source

Dysfunction in fatty acid amide hydrolase is associated with depressive-like behavior in Wistar Kyoto rats.

PLoS ONE, 2012
BackgroundWhile the etiology of depression is not clearly understood at the present time, this mental disorder is thought be a complex and multifactorial trait with important genetic and environmental contributing factors.Methodology/principal ...
K Yaragudri Vinod, Shan Xie, Delphine Psychoyos, Basalingappa L Hungund, Thomas B Cooper, Shanaz M Tejani-Butt   +5 more
doaj   +1 more source

Pharmacological activity of fatty acid amides is regulated, but not mediated by fatty acid amide hydrolase in [PDF]

, 2002
Fatty acid amides (FAAs) represent a class of neuromodulatory lipids that includes the endocannabinoid anandamide and the sleep-inducing substance oleamide.
E Gregory Hawkins, Graeme Griffin, Aron H Lichtman, Aron H. Lichtman, Benjamin F Cravatt, E. Gregory Hawkins, Benjamin F. Cravatt   +6 more
core  

Inhibition of the cellular uptake of anandamide by genistein and its analogue daidzein in cells with different levels of fatty acid amide hydrolase‐driven uptake

, 2007
Background and purpose: Genistein, a tyrosine kinase inhibitor used to block caveolae dependent endocytosis, reduces the cellular uptake of anandamide in RBL2H3 basophilic leukaemia cells.
J Eriksson, C J Fowler, Thors, Lina,, Eriksson, J, L Thors, Fowler, C J,   +5 more
core   +1 more source

A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase

, 2016
In addition to inhibiting the cyclooxygenase (COX)-mediated biosynthesis of prostanoids, various widely used nonsteroidal anti-inflammatory drugs (NSAIDs) enhance endocannabinoid signaling by blocking the anandamide-degrading membrane enzyme fatty acid ...
Laura Bertolacci (2005276), Clara Albani (2005270), Marco De Vivo (180746), Daniele Piomelli (180759), Elisa Romeo (1527994), Rita Scarpelli (1463797), Andrea Cavalli (102196), Mauro Dionisi (1912198), Chiara Lambruschini (2005279), Paola Magotti (2005273), Gianpiero Garau (1528000), Marina Veronesi (2005282)   +11 more
core   +1 more source

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity

, 2015
: Firefly luciferase is homologous to fatty acyl-CoA synthetases. We hypothesized that the firefly luciferase substrate D-luciferin and its analogs are fatty acid mimics that are ideally suited to probe the chemistry of enzymes that release fatty acid ...
Spencer T. Adams, G. S. Kiran Kumar Reddy, Heer Reddy, Stephen C. Miller (1336704), Spencer T. Adams (1361277), G. S. Kiran Kumar Reddy (1361274), David M. Mofford, Gadarla R, Gadarla Randheer Reddy (1336707), David M. Mofford (1336701), Stephen C. Miller   +10 more
core   +1 more source

Luciferin Amides Enable in Vivo Bioluminescence Detection of Endogenous Fatty Acid Amide Hydrolase Activity

, 2016
Firefly luciferase is homologous to fatty acyl-CoA synthetases. We hypothesized that the firefly luciferase substrate d-luciferin and its analogs are fatty acid mimics that are ideally suited to probe the chemistry of enzymes that release fatty acid ...
Adams, Spencer T. Jr, Reddy, Gadarla Randheer, Reddy, G. S. Kiran Kumar, Mofford, David M., Miller, Stephen C.   +4 more
core   +1 more source

Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. [PDF]

Int J Mol Sci, 2023
Kovacs D, Flori E, Bastonini E, Mosca S, Migliano E, Cota C, Zaccarini M, Briganti S, Cardinali G.   +8 more
europepmc   +1 more source

Cocaine-induced loss of LTD and social impairments are restored by fatty acid amide hydrolase inhibition. [PDF]

Sci Rep, 2023
Alegre-Zurano L, Caceres-Rodriguez A, Berbegal-Sáez P, Lassalle O, Manzoni O, Valverde O.   +5 more
europepmc   +1 more source

Characterization of Fatty Acid Amide Hydrolase in Physcomitrella Patens

, 2017
In plants, saturated and unsaturated N-acylethanolamines (NAEs) with acyl chains 12C to 18C are reported for their differential levels in various tissues and species.
Shinde, Suhas, Kilaru, Aruna, Haq, Imdadul   +2 more
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