Results 111 to 120 of about 11,683 (171)

Evaluating Fatty Acid Amide Hydrolase as a Suitable Target for Sleep Promotion in a Transgenic TauP301S Mouse Model of Neurodegeneration. [PDF]

Pharmaceuticals (Basel)
Martin SC, Joyce KK, Harper KM, Harp SJ, Cohen TJ, Moy SS, Diering GH.   +6 more
europepmc   +1 more source

Effect of MCH1, a fatty-acid amide hydrolase inhibitor, on the depressive-like behavior and gene expression of endocannabinoid and dopaminergic-signaling system in the mouse nucleus accumbens. [PDF]

Braz J Med Biol Res
Medina-Saldivar C, Pardo GVE, Pacheco-Otalora LF.   +2 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

The fatty acid amide hydrolase (FAAH)

Chemistry and Physics of Lipids, 2000
The topic of this review is fatty acid amide hydrolase (FAAH), one of the best-characterized enzymes involved in the hydrolysis of bioactive lipids such as anandamide, 2-arachidonoylglycerol (2-AG), and oleamide. Herein, we discuss the nomenclature, the various assays that have been developed, the relative activity of the various substrates and the ...
Dale G Deutsch, Natsuo Ueda, D G Deutsch
exaly   +3 more sources

Fatty Acid Amide Hydrolase: From Characterization to Therapeutics

Chemistry and Biodiversity, 2007
AbstractFatty acid amide hydrolase (FAAH) is an integral membrane enzyme within the amidase‐signature family that terminates the action of several endogenous lipid messengers, including oleamide and the endocannabinoid anandamide. The hydrolysis of such messengers leads to molecules devoid of biological activity, and, therefore, modulates a number of ...
Catherine Michaux
exaly   +4 more sources

The fatty acid amide hydrolase (FAAH)

Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002
The fatty acid amide hydrolase (FAAH), is the enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH knockout, the assays for FAAH, the activity of its substrates, its reversibility and its cloning from rat, mouse, human, and pig are covered in this review.
D G, Deutsch, N, Ueda, S, Yamamoto
openaire   +2 more sources

Anandamide amidohydrolase (fatty acid amide hydrolase)

Prostaglandins & Other Lipid Mediators, 2000
Anandamide (N-arachidonoylethanolamine) loses its cannabimimetic activity when it is hydrolyzed to arachidonic acid and ethanolamine by the catalysis of an enzyme referred to as anandamide amidohydrolase or fatty acid amide hydrolase. Cravatt's group and our group cloned cDNA of the enzyme from rat, human, mouse and pig, and the primary structures ...
N, Ueda, S, Yamamoto
openaire   +2 more sources

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

Bioorganic and Medicinal Chemistry Letters, 2008
A series of thiadiazolopiperazinyl aryl urea fatty acid amide hydrolase (FAAH) inhibitors is described. The molecules were found to inhibit the enzyme by acting as mechanism-based substrates, forming a covalent bond with Ser241. SAR and PK properties are presented.
Lin Luo, Richard L. Apodaca, John M Keith   +2 more
exaly   +3 more sources

STRUCTURE AND FUNCTION OF FATTY ACID AMIDE HYDROLASE

Annual Review of Biochemistry, 2005
▪ Abstract  Fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme that degrades the fatty acid amide family of endogenous signaling lipids, which includes the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide.
Michele K, McKinney, Benjamin F, Cravatt
openaire   +2 more sources